A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes

2016 ◽  
Vol 8 (1) ◽  
pp. 91-103 ◽  
Author(s):  
Jörn Lötsch ◽  
Alfred Ultsch
Keyword(s):  
Functional Genomics ◽  
Biological Role ◽  
Active Line ◽  
Jumping Genes ◽  
The Given ◽  
Over Time ◽  
Cell Specialization

LINE-1 retrotransposition may result in silencing of genes. This is more likely with genes not carrying active LINE-1 as those are about 10 times more frequent in the given set of genes. Over time this leads to self-specialization of the cell toward processes associated with gene carrying active LINE-1, which then functionally prevail in the chronified situation.

scholarly journals “Like Stitches to a Wound”: Fashioning Taste in and Through Garment Mending Practices

2021 ◽  
pp. 089124162110120
Author(s):  
Marium Durrani
Keyword(s):  
The Body ◽  
Fast Fashion ◽  
The World ◽  
Dress Practices ◽  
The Given ◽  
Over Time

This article immerses the reader into the world of garment mending in communal repair events in four cities— Helsinki, Auckland, Wellington, and Edinburgh—to explore mending as a locus of taste. It engages in the discussion on taste as a reflexive activity and a sensed effect that gradually reveals itself to the practitioners engaged in the practice of mending. Here the focus is on the role of the body and the interplay between the sensing body and materials, to show how everyday menders construct a taste for and toward their practice over time. As menders actively engage with and appropriate the given design of their garments, they defy mainstream wasteful fast-fashion practices and mobilize variations in dress practices while connecting with the matter that makes up their clothing . By engaging with the notion of taste in this way, the overall aim of this article is to clarify how everyday menders become able to form an alliance with their practice, ultimately converting mending into an object of passion.

scholarly journals Why Extending Actions through Time Can Violate a Moral Right to Privacy

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Björn Lundgren
Keyword(s):  
Right To Privacy ◽  
The Right To Privacy ◽  
Definition Of ◽  
The Right ◽  
The Given ◽  
Related Harm ◽  
Over Time ◽  
Reverse Position

Recently, Ingmar Persson and Julian Savulescu argued that an action that does not violate a moral right to privacy cannot violate that right if it is extended over time. Specifically, they argue that a moral right to privacy does not protect against gawking or stalking. In this reply the reverse position is defended. Specifically, it is argued that their arguments fails on according to their own definition of the right to privacy. Furthermore, it is argued and illustrated by examples that this conceptual conclusion holds for many other conceptions of the right to privacy. Moreover, it is argued that Persson and Savluescu fail to recognize the privacy-related harm extended to individuals through gawking or stalking. Lastly, the article ends by sketching how the role of privacy in public and consent relates to the given examples.

scholarly journals THE VICTIM AS A FORGOTTEN FIGURE IN THE JUSTICE SYSTEM – A FEW REMARKS IN THE LIGHT OF PAST FORMS OF PUNISHMENT

2017 ◽  
Vol 31 (4) ◽  
pp. 33-44
Author(s):  
Agnieszka Kania
Keyword(s):  
Middle Ages ◽  
Criminal Law ◽  
Justice System ◽  
Historical Period ◽  
System A ◽  
Starting Point ◽  
Private Matter ◽  
The Given ◽  
Over Time

This article focuses on selected problems regarding the evolution of the punishment process. The starting point remains the assumption that regardless of the historical period, every palpable form of injustice related to a violation of a certain area of goods has resulted in an intervention approved at the given moment in history. The study notes that in the early pre-state period, seeking a remedy for wrongdoing was a private matter of the victim (or their family or clan) who could in that wayavenge on their own the injustice they had suffered. The process of publicising criminal law that began at the end of the Middle Ages has marginalised the process role of a victim in the possibilities to seek the remedy. However, the vertical criminal law relationship has, over time, changed to some extent. The privatisation of the justice system – especially noticeable nowadays – makes it possible to see that consensual methods of resolving conflicts caused by an offenceessentially contributed to the reversal of a certain historical process. That reversal was certainly intended to “reveal” the victim, and thus to return the conflict resulting from the offence to its “owners,” i.e. the perpetrator and the victim.

THE ISSUE OF MINORS’S GUARDIANSHIP SENTENCED TO IMPRISONMENT

2020 ◽  
pp. 33-37
Author(s):  
Ирина Викторовна Евстафьева
Keyword(s):  
Juvenile Offenders ◽  
Legal Status ◽  
Careful Consideration ◽  
Point Of View ◽  
Sufficient Detail ◽  
Domestic Legislation ◽  
The Status ◽  
Correct Understanding ◽  
The Given

В статье исследуются вопросы попечительства в отношении несовершеннолетних, отбывающих наказание в виде лишения свободы. Проблема, поднимаемая автором настоящей статьи, многогранна, касается различных аспектов отбывания наказания несовершеннолетними в воспитательных колониях и требует комплексного исследования, способного ответить на определенно значимый вопрос: является ли колония законным представителем находящихся в ней несовершеннолетних со всеми вытекающими из статуса законных представителей последствиями. При этом необходимо обращать внимание на специфику правового статуса лиц, отбывающих наказание в воспитательных колониях, которые, во-первых, являются несовершеннолетними, то есть не обладают дееспособностью в полном объеме и нуждаются в особой заботе, защите и представительстве, а во-вторых, осуждены за совершение тяжкого или особо тяжкого преступления, влекущего изоляцию от общества и определенные ограничения и лишения. Отечественное законодательство достаточно детально регламентирует особенности режима отбывания наказания в виде лишения свободы несовершеннолетними, не определяя при этом статуса воспитательных колоний, кем они являются: воспитателями, попечителями или исключительно учреждениями исполнения наказаний. Между тем правильное понимание значения и роли воспитательной колонии в жизни находящихся в ней несовершеннолетних преступников, по мнению автора, поможет избежать ряда проблем, объективно складывающихся в учреждениях подобного рода. С этой точки зрения предлагаемая тема представляет интерес не только для ученых-теоретиков, но и для практиков - сотрудников соответствующих учреждений. Особо следует подчеркнуть, что исследований по данной тематике в специальной литературе нет. Отдельные исследования, встречающиеся в современной литературе, касаются исключительно общего гражданско-правового статуса несовершеннолетних осужденных. Однако это обстоятельство может свидетельствовать только о новизне данной темы, но никак не об отсутствии самой проблемы. The article analyzes the issues of the status of educational colonies as guardians of minors serving a sentence of imprisonment. In fact, the problem raised by the author of this article is multifaceted, concerns various aspects of the serving of punishment by minors in educational colonies and requires a comprehensive study that can answer, it seems, a definitely significant question: whether the colony is the legal representative of the minors in it with all the consequences arising from the status of legal representatives in the form of duties and responsibilities. At the same time, it seems, it is necessary to pay attention to the specifics of the legal status of citizens serving sentences in educational colonies, who, firstly, are minors, i.e. do not have full legal capacity and need special care, protection and representation, and, secondly, are convicted of committing a serious or particularly serious crime, entailing isolation from society and certain restrictions and deprivation. Domestic legislation regulates in sufficient detail the peculiarities of the regime of serving sentences in the form of deprivation of liberty by minors, without determining the status of educational colonies. Who are they: educators, Trustees or only institutions of execution of punishments. Meanwhile, the correct understanding of the importance and role of the educational colony in the life of juvenile offenders in it, according to the author, will help to avoid a number of problems that objectively develop in institutions of this kind. From this point of view, the proposed topic is of interest not only for theoretical scientists, but for practitioners-employees of relevant institutions. It should be emphasized that there are no studies on this subject in the special literature. However, this circumstance can testify only about novelty of the given subject, but in any way about absence of the problem. It seems that the relevance and importance of a problem is not always measured by the number of studies devoted to it. Sometimes these its traits are manifest only under particularly careful consideration.

Raza, ciencia, sociedad

2015 ◽  
Vol 2 (4) ◽  
Author(s):  
Peter Wade
Keyword(s):  
Cultural Discourse ◽  
Human Biology ◽  
Science And Society ◽  
Race Science ◽  
And Behavior ◽  
Over Time

<p class="p1"><span class="s1"><strong>Resumen </strong></span>| En este trabajo quiero presentar una cronología convencional del concepto raza que marca un movimiento en el cual raza cambia de ser una idea basada en la cultura y el medio ambiente, a ser algo biológico, inflexible y determinante, para luego volver a ser una noción que habla de la cultura<span class="s2"><strong>.</strong></span>Resumo cómo la idea de raza ha cambiado a través del tiempo, mirando necesariamente el rol que ha desempeñado la ciencia, y enfocando los diferentes discursos de índole <em>natural-cultural </em>sobre los cuerpos, el medio ambiente y el comportamiento, en los cuales las dimensiones culturales y naturales siempre coexisten<span class="s2"><strong>.</strong></span>“La naturaleza” no puede ser entendida solamente como “la biología” y ni la naturaleza ni la biología necesariamente implican sólo el determinismo, la fijeza y la inmutabilidad Estar abiertos a la coexistencia de la cultura y la naturaleza y a la mutabilidad de la naturaleza nos permite ver mejor el ámbito de acción del pensamiento racial.</p><p class="p1"><strong><em>Race, Science and Society</em></strong></p><p class="p1"> </p><p class="p2"><span class="s1"><strong>Abstract </strong></span>| In this article I present and critique a standard chronology of race as, first, a concept rooted in culture and environment, and later in human biology and determinism, and finally back to culture alone<span class="s2"><strong><em>.</em></strong></span>I will outline changing understandings of race over time, with some attention to the role of science, broadly understood, and on the continuing but changing character of race as a natural-cultural discourse about organic bodies, environments and behavior, in which both cultural and natural dimensions always co-exist<span class="s2"><strong><em>.</em></strong></span>“Nature” is not to be understood simply as “biology,” and neither nature nor biology necessarily imply the fixity and determination that they are often assumed nowadays to involve<span class="s2"><strong><em>.</em></strong></span>Being open to the co-existence of culture and nature and the mutability of the latter allows us to better comprehend the whole range of action of racial thinking.</p>

From Organizations of Processes to Organisms and Other Biological Individuals

2018 ◽  
Author(s):  
Argyris Arnellos
Keyword(s):  
Multicellular Organism ◽  
Collaborative Networks ◽  
Biological Role ◽  
Regulatory Processes ◽  
Different Types ◽  
Organizational Framework

The emphasis on the collaborative dimension of life overlooks the importance of biological individuals (conceived of as integrated, self-maintaining organizations) in the build-up of more complex collaborative networks in the course of evolution. This chapter proposes a process-based organizational ontology for biology, according to which the essential features of unicellular organismicality are captured by a self-maintaining organization of processes integrated by means of a special type of collaboration (realized through regulatory processes entailing an indispensable interdependence) between its constitutive and its interactive aspects. This ontology is then used to describe different types of collaborations among cells and to suggest the type that yields a multicellular organism. The proposed organizational framework enables us to critically assess hypercollaborative views of life, especially issues related to the distinction between biological individuals and organisms and between life and non-life, without however underestimating the central biological role of collaboration.

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