Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells

2016 ◽  
Vol 7 (1) ◽  
pp. 315-325 ◽  
Author(s):  
Li Zhang ◽  
Xian Cheng ◽  
Yanyan Gao ◽  
Jiandong Bao ◽  
Haixia Guan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Cycle Arrest ◽  
Papillary Thyroid ◽  
M Cell ◽  
Cycle Arrest

Curcumin induces DNA damage, resulting in G2/M cell cycle arrest and following apoptosis in BCPAP cells via activation of an ATM-Chk2-Cdc25C-Cdc2 cascade.

Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

2015 ◽  
Vol 6 (11) ◽  
pp. 3464-3472 ◽  
Author(s):  
Li Zhang ◽  
Xian Cheng ◽  
Yanyan Gao ◽  
Jie Zheng ◽  
Qiang Xu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Death ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cell Cycle Arrest ◽  
Autophagic Cell Death ◽  
Ros Generation ◽  
Papillary Thyroid ◽  
Cycle Arrest

Apigenin-induced autophagic cell death in human papillary thyroid carcinoma BCPAP cells is associated with ROS generation, DNA damage and cell cycle arrest.

scholarly journals Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

2015 ◽  
Vol 36 (9) ◽  
pp. 1113-1125 ◽  
Author(s):  
Qing-qing Zhang ◽  
Wen-juan Wang ◽  
Jun Li ◽  
Neng Yang ◽  
Gang Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Cathepsin L ◽  
Human Glioma ◽  
M Cell ◽  
Cycle Arrest ◽  
U251 Cells

scholarly journals Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88140 ◽  
Author(s):  
Jiajie Guo ◽  
Guosheng Wu ◽  
Jiaolin Bao ◽  
Wenhui Hao ◽  
Jinjian Lu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Dependent Manner ◽  
M Cell ◽  
Cucurbitacin B ◽  
Cycle Arrest

scholarly journals Oxidative Stress Causes Enhanced Secretion of YB-1 Protein that Restrains Proliferation of Receiving Cells

Genes ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 513 ◽  
Author(s):  
Andrea Maria Guarino ◽  
Annaelena Troiano ◽  
Elio Pizzo ◽  
Andrea Bosso ◽  
Maria Vivo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Matrix Protein ◽  
Resting Cells ◽  
Messenger Rnas ◽  
M Cell ◽  
Cycle Arrest ◽  
Ribonucleoprotein Particles

The prototype cold-shock Y-box binding protein 1 (YB-1) is a multifunctional protein that regulates a variety of fundamental biological processes including cell proliferation and migration, DNA damage, matrix protein synthesis and chemotaxis. The plethora of functions assigned to YB-1 is strictly dependent on its subcellular localization. In resting cells, YB-1 localizes to cytoplasm where it is a component of messenger ribonucleoprotein particles. Under stress conditions, YB-1 contributes to the formation of stress granules (SGs), cytoplasmic foci where untranslated messenger RNAs (mRNAs) are sorted or processed for reinitiation, degradation, or packaging into ribonucleoprotein particles (mRNPs). Following DNA damage, YB-1 translocates to the nucleus and participates in DNA repair thereby enhancing cell survival. Recent data show that YB-1 can also be secreted and YB-1-derived polypeptides are found in plasma of patients with sepsis and malignancies. Here we show that in response to oxidative insults, YB-1 assembly in SGs is associated with an enhancement of YB-1 protein secretion. An enriched fraction of extracellular YB-1 (exYB-1) significantly inhibited proliferation of receiving cells and such inhibition was associated to a G2/M cell cycle arrest, induction of p21WAF and reduction of Np63 protein level. All together, these data show that acute oxidative stress causes sustained release of YB-1 as a paracrine/autocrine signal that stimulate cell cycle arrest.

ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells

FEBS Letters ◽  
2004 ◽  
Vol 570 (1-3) ◽  
pp. 7-12 ◽  
Author(s):  
Xin Zhang ◽  
Lu-Sheng Xu ◽  
Zhi-Qin Wang ◽  
Ke-Sheng Wang ◽  
Na Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Hepg2 Cells ◽  
M Cell ◽  
Cycle Arrest

scholarly journals DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1

Oncotarget ◽  
2014 ◽  
Vol 6 (1) ◽  
pp. 427-440 ◽  
Author(s):  
Jogitha Selvarajah ◽  
Androulla Elia ◽  
Veronica A. Carroll ◽  
Abdeladim Moumen
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
M Cell ◽  
Cycle Arrest
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