scholarly journals Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

2015 ◽  
Vol 36 (9) ◽  
pp. 1113-1125 ◽  
Author(s):  
Qing-qing Zhang ◽  
Wen-juan Wang ◽  
Jun Li ◽  
Neng Yang ◽  
Gang Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Cathepsin L ◽  
Human Glioma ◽  
M Cell ◽  
Cycle Arrest ◽  
U251 Cells

scholarly journals Cytochalasin B inhibits the proliferation of human glioma U251 cells through cell cycle arrest and apoptosis

2014 ◽  
Vol 13 (4) ◽  
pp. 10811-10822 ◽  
Author(s):  
Z.G. Tong ◽  
N. Liu ◽  
H.S. Song ◽  
J.Q. Li ◽  
J. Jiang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cytochalasin B ◽  
Human Glioma ◽  
Cycle Arrest ◽  
U251 Cells

Induction of G1 Cell Cycle Arrest in Human Glioma Cells by Salinomycin Through Triggering ROS-Mediated DNA Damage In Vitro and In Vivo

2016 ◽  
Vol 42 (4) ◽  
pp. 997-1005 ◽  
Author(s):  
Shi-Jun Zhao ◽  
Xian-Jun Wang ◽  
Qing-Jian Wu ◽  
Chao Liu ◽  
Da-Wei Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

scholarly journals β-Asarone Induces Apoptosis and Cell Cycle Arrest of Human Glioma U251 Cells via Suppression of HnRNP A2/B1-Mediated Pathway In Vitro and In Vivo

Molecules ◽  
2018 ◽  
Vol 23 (5) ◽  
pp. 1072 ◽  
Author(s):  
Li Li ◽  
Yi Yang ◽  
Mingxia Wu ◽  
Zanyang Yu ◽  
Chengqiang Wang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Glioma ◽  
Cycle Arrest ◽  
U251 Cells

scholarly journals Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88140 ◽  
Author(s):  
Jiajie Guo ◽  
Guosheng Wu ◽  
Jiaolin Bao ◽  
Wenhui Hao ◽  
Jinjian Lu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Dependent Manner ◽  
M Cell ◽  
Cucurbitacin B ◽  
Cycle Arrest

Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma

2007 ◽  
Vol 85 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Enyu Liu ◽  
Jing Wu ◽  
Weidong Cao ◽  
Jianning Zhang ◽  
Weiping Liu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Dependent Manner ◽  
Human Glioma ◽  
M Cell ◽  
Cycle Arrest

scholarly journals Oxidative Stress Causes Enhanced Secretion of YB-1 Protein that Restrains Proliferation of Receiving Cells

Genes ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 513 ◽  
Author(s):  
Andrea Maria Guarino ◽  
Annaelena Troiano ◽  
Elio Pizzo ◽  
Andrea Bosso ◽  
Maria Vivo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Dna Damage ◽  
Cell Cycle Arrest ◽  
Matrix Protein ◽  
Resting Cells ◽  
Messenger Rnas ◽  
M Cell ◽  
Cycle Arrest ◽  
Ribonucleoprotein Particles

The prototype cold-shock Y-box binding protein 1 (YB-1) is a multifunctional protein that regulates a variety of fundamental biological processes including cell proliferation and migration, DNA damage, matrix protein synthesis and chemotaxis. The plethora of functions assigned to YB-1 is strictly dependent on its subcellular localization. In resting cells, YB-1 localizes to cytoplasm where it is a component of messenger ribonucleoprotein particles. Under stress conditions, YB-1 contributes to the formation of stress granules (SGs), cytoplasmic foci where untranslated messenger RNAs (mRNAs) are sorted or processed for reinitiation, degradation, or packaging into ribonucleoprotein particles (mRNPs). Following DNA damage, YB-1 translocates to the nucleus and participates in DNA repair thereby enhancing cell survival. Recent data show that YB-1 can also be secreted and YB-1-derived polypeptides are found in plasma of patients with sepsis and malignancies. Here we show that in response to oxidative insults, YB-1 assembly in SGs is associated with an enhancement of YB-1 protein secretion. An enriched fraction of extracellular YB-1 (exYB-1) significantly inhibited proliferation of receiving cells and such inhibition was associated to a G2/M cell cycle arrest, induction of p21WAF and reduction of Np63 protein level. All together, these data show that acute oxidative stress causes sustained release of YB-1 as a paracrine/autocrine signal that stimulate cell cycle arrest.

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