Anti-diabetic activity of peony seed oil, a new resource food in STZ-induced diabetic mice

2015 ◽  
Vol 6 (9) ◽  
pp. 2930-2938 ◽  
Author(s):  
Jianhui Su ◽  
Hongxin Wang ◽  
Caoyang Ma ◽  
Zaixiang Lou ◽  
Chengxiang Liu ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Linoleic Acid ◽  
Blood Glucose ◽  
Linolenic Acid ◽  
Seed Oil ◽  
Fasting Blood Glucose ◽  
Diabetic Mice

Peony seed oil rich in α-linolenic acid (38.66%), linoleic acid (26.34%) and oleic acid (23.65%) reduced fasting blood glucose of diabetic mice induced by STZ.

scholarly journals Flax Seed

2021 ◽  
Vol 5 (5) ◽  
pp. 01-02
Author(s):  
Hayriye Alp
Keyword(s):  
Oleic Acid ◽  
Linoleic Acid ◽  
Linolenic Acid ◽  
Seed Oil ◽  
Linseed Oil ◽  
Flaxseed Oil ◽  
Flax Seed ◽  
Alpha Linolenic Acid ◽  
Flax Oil ◽  
Secoisolariciresinol Diglycoside

Flax sed also known as flax oil and linseed oil, is derived from the seeds of the plant Linium usitatissimum. Flax seed oil is a very rich source of alpha-linolenic acid. Alpha-linolenic acid concentration in flaxseed oil ranges from approximately 40 to 60%.lower amounts of linoleic acid and oleic acid (each about 15%) are also present in flaxseed oil.ın addition, flaxseed contains varying amounts of the lignan, secoisolariciresinol diglycoside (SDG).

scholarly journals Inhibition of steroid 5α-reductase by specific aliphatic unsaturated fatty acids

1992 ◽  
Vol 285 (2) ◽  
pp. 557-562 ◽  
Author(s):  
T Liang ◽  
S Liao
Keyword(s):  
Fatty Acids ◽  
Oleic Acid ◽  
Linoleic Acid ◽  
Linolenic Acid ◽  
Unsaturated Fatty Acids ◽  
Binding Assay ◽  
Reductase Activity ◽  
Undecylenic Acid ◽  
Gamma Linolenic Acid ◽  
Enzymic Assay

Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory potencies of unsaturated fatty acids are, in decreasing order: gamma-linolenic acid greater than cis-4,7,10,13,16,19-docosahexaenoic acid = cis-6,9,12,15-octatetraenoic acid = arachidonic acid = alpha-linolenic acid greater than linoleic acid greater than palmitoleic acid greater than oleic acid greater than myristoleic acid. Other unsaturated fatty acids such as undecylenic acid, erucic acid and nervonic acid, are inactive. The methyl esters and alcohol analogues of these compounds, glycerols, phospholipids, saturated fatty acids, retinoids and carotenes were inactive even at 0.2 mM. The results of the binding assay and the enzymic assay correlated well except for elaidic acid and linolelaidic acid, the trans isomers of oleic acid and linoleic acid respectively, which were much less active than their cis isomers in the binding assay but were as potent in the enzymic assay. gamma-Linolenic acid had no effect on the activities of two other rat liver microsomal enzymes: NADH:menadione reductase and glucuronosyl transferase. gamma-Linolenic acid, the most potent inhibitor tested, decreased the Vmax. and increased Km values of substrates, NADPH and testosterone, and promoted dissociation of [3H]4-MA from the microsomal reductase. gamma-Linolenic acid, but not the corresponding saturated fatty acid (stearic acid), inhibited the 5 alpha-reductase activity, but not the 17 beta-dehydrogenase activity, of human prostate cancer cells in culture. These results suggest that unsaturated fatty acids may play an important role in regulating androgen action in target cells.

scholarly journals FATTY ACIDS COMPOSITION OF TOCTE (JUGLANS NEOTROPICA DIELS) WALNUT FROM ECUADOR

2018 ◽  
Vol 11 (2) ◽  
pp. 395 ◽  
Author(s):  
Vilcacundo E ◽  
Alvarez M ◽  
Silva M ◽  
Carpio C ◽  
Morales D ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oleic Acid ◽  
Linoleic Acid ◽  
Stearic Acid ◽  
Palmitic Acid ◽  
Linolenic Acid ◽  
Lipid Content ◽  
Methyl Esters ◽  
Total Lipid Content ◽  
Fatty Acids Composition

 Objective: The aim of this study was to determine the fatty acids composition in a tocte seeds oil (Juglans neotropica Diels) sample cultivated in Ecuador.Methods: Tocte oil was obtained from tocte seeds using the cold pressing method. Fatty acids analysis was carried out using the gas chromatography method with a mass selective detector (GC/MSD) and using the database Library NIST14.L to identify the compounds.Results: Methyl esters fatty acids were identified from tocte (J. neotropica Diels) walnut using the GC–MS analytical method. The total lipid content of tocte walnuts seeds of plants cultivated in Ecuador was of 49.01% of the total lipid content on fresh weight. Fatty acids were analyzed as methyl esters on a capillary column DB-WAX 122-7062 with a good separation of palmitic acid, stearic acid, oleic acid, linoleic acid, and linolenic acid. The structure of methyl esters fatty acids was determined using the GC–MS. Tocte walnut presents 5.05% of palmitic acid, 2.26% of stearic acid, 19.50% of oleic acid, 65.81% of linoleic acid, and 2.79% linolenic acid of the total content of fatty acids in tocte oil. Fatty acids content reported in this study were similar to the data reported for other walnuts seeds.Conclusions: Tocte seeds are a good source of monounsaturated and polyunsaturated fatty acids. Tocte oil content oleic acid and with a good content of ɷ6 α-linoleic and ɷ3 α-linolenic. Tocte walnut can help reduce risk cardiovascular diseases in Ecuador for their good composition of fatty acids.

scholarly journals Effect of Alpha-Linolenic Acid on Blood Glucose, Insulin and GLUT4 Protein Content of Type 2 Diabetic Mice.

2000 ◽  
Vol 46 (6) ◽  
pp. 489-492 ◽  
Author(s):  
Motoshi Kato ◽  
Toshihiro Miura ◽  
Masami Nakao ◽  
Naoki Iwamoto ◽  
Torao Ishida ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Protein Content ◽  
Linolenic Acid ◽  
Diabetic Mice ◽  
Alpha Linolenic Acid ◽  
Type 2 Diabetic

scholarly journals Effect of reduced dietary zinc intake on carbohydrate and Zn metabolism in the genetically diabetic mouse (C57BL/KsJ db+/db+)

1988 ◽  
Vol 60 (3) ◽  
pp. 499-507 ◽  
Author(s):  
Susan Southon ◽  
Z. Kechrid ◽  
A. J. A. Wright ◽  
Susan J. Fairweather-Tait
Keyword(s):  
Blood Glucose ◽  
Control Diet ◽  
Fasting Blood Glucose ◽  
Liver Glycogen ◽  
Diabetic Mouse ◽  
Whole Body ◽  
Diabetic Mice ◽  
Control Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels

1. Male, 4–5-week-old, genetically diabetic mice (C57BL/KsJ db/db) and non-diabetic heterozygote litter-mates (C57BL/KsJ db/+)were fed on a diet containing 1 mg zinc/kg (low-Zn groups) or 54 mg Zn/kg (control groups) for 27 d. Food intakes and body-weight gain were recorded regularly. On day 28, after an overnight fast, animals were killed and blood glucose and insulin concentrations, liver glycogen, and femur and pancreatic Zn concentrations were determined.2. The consumption of the low-Zn diet had only a minimal effect on the Zn status of the mice as indicated by growth rate, food intake and femur and pancreatic Zn concentrations. In fact, diabetic mice fed on the low-Zn diet had a higher total food intake than those fed on the control diet. The low-Zn diabetic mice had higher fasting blood glucose and liver glycogen levels than their control counterparts. Fasting blood insulin concentration was unaffected by dietary regimen.3. A second experiment was performed in which the rate of loss of 65Zn, injected subcutaneously, was measured by whole-body counting in the two mouse genotypes over a 28 d period, from 4 to 5 weeks of age. The influence of feeding low-Zn or control diets was also examined. At the end of the study femur and pancreatic Zn and non-fasting blood glucose levels were determined.4. All mice fed on the low-Zn diet showed a marked reduction in whole-body 65Zn loss compared with those animals fed on the control diet. In the low-Zn groups, the loss of 65Zn from the diabetic mice was significantly greater than that from heterozygote mice. This difference was not observed in the control groups. Blood glucose levels were elevated in the low-Zn groups. Possible reasons for these observations are discussed.5. The present study demonstrates an adverse effect of reduced dietary Zn intake on glucose utilization in the genetically diabetic mouse, which occurred before any significant tissue Zn depletion became apparent.

scholarly journals The (-)-epigallocatechin gallate (EGCG) ameliorates hyperglycemia and hyperlipidemia - mediated oxidative stress in liver and kidney of alloxan induced diabetic mice

2020 ◽  
Author(s):  
Ahlem SOUSSI ◽  
Manel GARGOURI ◽  
Sirine AOUEDI ◽  
Amel AKROUTI ◽  
Christian MAGNE ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Epigallocatechin Gallate ◽  
Future Application ◽  
Antioxidant Enzyme Activities ◽  
Diabetic Mice ◽  
Liver And Kidney ◽  
Health Complications ◽  
Kidney Functions ◽  
Toxicity Indices

Abstract Background: Diabetes mellitus has become a serious problem associated with health complications, such as metabolism disorders and liver-kidney dysfunctions. The inadequacies associated with conventional medicines have led to a determined search for alternative natural therapeutic agents. The present study is conducted to evaluate the hypoglycemic, antilipidemic and antioxidant effects of EGCG in surviving diabetic mice.Methods: Alloxan diabetic mice were injected with EGCG. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglycerides, urea, creatinine and transaminases. Their livers and kidneys were isolated to perform histological analysis.Results: Both EGCG and insulin treatments of diabetic mice resulted in a significant reduction in fasting blood glucose level. EGCG supplementation also ameliorated hepatic as well as renal toxicity indices. Moreover, diabetic mice injected by EGCG exhibited significant changes in antioxidant enzyme activities in the liver and kidney. Histological analyses also showed that it exerted an ameliorative action on these organs and efficiently protected the liver-kidney functions of diabetic mice.Conclusion: The findings revealed that EGCG administration induced attractive curative effects on diabetic mice, particularly in terms of liver-kidney functions. EGCG can, therefore, be considered as a potential strong candidate for future application to treat and prevent diabetes.

scholarly journals Uptake and removal of oil in water by means of gels

2013 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Mateus Gonzales Domiciano ◽  
Ailey Aparecida Coelho ◽  
Regiane Da Silva
Keyword(s):  
Oleic Acid ◽  
Linoleic Acid ◽  
Erucic Acid ◽  
Linolenic Acid ◽  
Palmitoleic Acid ◽  
Eicosenoic Acid ◽  
Synthesis Process ◽  
Nervonic Acid ◽  
Polymeric Networks ◽  
Oil In Water

<p>3D gels are polymeric networks, able to absorb solvents. In this work, starch and PVA gels were developed to act removing oil from water. The oil absorbing capacity can be suitable along with their composition through the synthesis process. Starch and PVA gels were grafted with palmitoleic acid, oleic acid, linoleic acid, linolenic acid, eicosenoic acid, erucic acid and nervonic acid, showing ability to absob up to 50% of weight in oil. When dried or swollen, the gels presented a handling resistance, considered important for using and removal of oil in water.</p><p>&nbsp;</p><p>DOI: http://dx.doi.org/10.14685/rebrapa.v3i1.81</p>

scholarly journals Metabolic impacts of cordycepin on hepatic proteomic expression in streptozotocin-induced type 1 diabetic mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256140
Author(s):  
Kongphop Parunyakul ◽  
Krittika Srisuksai ◽  
Sawanya Charoenlappanit ◽  
Narumon Phaonakrop ◽  
Sittiruk Roytrakul ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Signaling Pathway ◽  
Tricarboxylic Acid Cycle ◽  
Fasting Blood Glucose ◽  
Protein Profiling ◽  
Diabetic Mice ◽  
Final Body Weight ◽  
Significant Difference

Type 1 Diabetes mellitus (T1DM) is associated with abnormal liver function, but the exact mechanism is unclear. Cordycepin improves hepatic metabolic pathways leading to recovery from liver damage. We investigated the effects of cordycepin in streptozotocin-induced T1DM mice via the expression of liver proteins. Twenty-four mice were divided into four equal groups: normal (N), normal mice treated with cordycepin (N+COR), diabetic mice (DM), and diabetic mice treated with cordycepin (DM+COR). Mice in each treatment group were intraperitoneally injection of cordycepin at dose 24 mg/kg for 14 consecutive days. Body weight, blood glucose, and the tricarboxylic acid cycle intermediates were measured. Liver tissue protein profiling was performed using shotgun proteomics, while protein function and protein-protein interaction were predicted using PANTHER and STITCH v.5.0 software, respectively. No significant difference was observed in fasting blood glucose levels between DM and DM+COR for all time intervals. However, a significant decrease in final body weight, food intake, and water intake in DM+COR was found. Hepatic oxaloacetate and citrate levels were significantly increased in DM+COR compared to DM. Furthermore, 11 and 36 proteins were only expressed by the N+COR and DM+COR groups, respectively. Three unique proteins in DM+COR, namely, Nfat3, Flcn, and Psma3 were correlated with the production of ATP, AMPK signaling pathway, and ubiquitin proteasome system (UPS), respectively. Interestingly, a protein detected in N+COR and DM+COR (Gli3) was linked with the insulin signaling pathway. In conclusion, cordycepin might help in preventing hepatic metabolism by regulating the expression of energy-related protein and UPS to maintain cell survival. Further work on predicting the performance of metabolic mechanisms regarding the therapeutic applications of cordycepin will be performed in future.

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