Synthesis of mesoporous-silica-coated Gd2O3:Eu@silica particles as cell imaging and drug delivery agents

2016 ◽  
Vol 45 (17) ◽  
pp. 7443-7449 ◽  
Author(s):  
Weiye Song ◽  
Weihua Di ◽  
Weiping Qin
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Silica Particles

Luminescent lanthanide-based nanoparticles coated with mesoporous silica can be potentially used for cell imaging and drug delivery.

Mesoporous silica coated Gd2(CO3)3:Eu hollow nanospheres for simultaneous cell imaging and drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (67) ◽  
pp. 62320-62326 ◽  
Author(s):  
Yanli Wu ◽  
Xianzhu Xu ◽  
Xi Chen ◽  
Ruchun Yang ◽  
Qiang Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mr Imaging ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Hollow Structure ◽  
Hollow Nanospheres

The efficient optical/MR imaging capabilities, and the hollow structure make Gd2(CO3)3:Eu@mSiO2 a promising platform for simultaneous bioimaging and drug delivery.

AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

2016 ◽  
Vol 22 (11) ◽  
pp. 3681-3685 ◽  
Author(s):  
Zhiying Fan ◽  
Dongdong Li ◽  
Xue Yu ◽  
Yuping Zhang ◽  
Yong Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Silica Nanospheres ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

Biotemplated Hollow Mesoporous Silica Particles as Efficient Carriers for Drug Delivery

2021 ◽  
Author(s):  
Marzieh Heidari Nia ◽  
Roya Koshani ◽  
Jose G. Munguia-Lopez ◽  
Ali Reza Kiasat ◽  
Joseph M. Kinsella ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Particles ◽  
Hollow Mesoporous Silica

scholarly journals Myristic Acid Coated Protein Immobilised Mesoporous Silica Particles as pH Induced Oral Delivery System for the Delivery of Biomolecules

2019 ◽  
Vol 12 (4) ◽  
pp. 153
Author(s):  
Vivek Trivedi ◽  
Ruchir Bhomia ◽  
John C Mitchell
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Protein Conformation ◽  
Myristic Acid ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Silica Particles ◽  
Protein Release ◽  
Simulated Gastric Fluid

Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules using mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF) processing as encapsulation technique. The use of organic solvents or harsh processing conditions in the development of drug delivery systems for biomolecules can be detrimental for the structural integrity of the molecule. Hence, the coating on protein-immobilised particles was performed via supercritical carbon dioxide (scCO2) processing at a temperature lower than the melting point of myristic acid (MA) to avoid any thermal degradation of bHb. The SCDDS were prepared by bHb immobilisation on mesoporous silica followed by myristic acid (MA) coating at 43 °C and 100 bar in scCO2. bHb-immobilised silica particles were also coated via solvent evaporation (SE) to compare the protein release with scCO2 processed formulations. In both cases, MA coating provided required enteric protection and restricted the bHb release for the first two hours in simulated gastric fluid (SGF). The protein release was immediate upon the change of media to simulated intestinal fluid (SIF), reaching 70% within three hours. The release from SCF processed samples was slower than SE formulations, indicating superior surface coverage of MA on particles in comparison to the SE method. Most importantly, the protein conformation remained unchanged after the release from SCDDS as confirmed by circular dichroism. This study clearly demonstrates that the approach involving protein immobilisation on silica and scCO2 assisted melt-coating method can protect biomolecules from gastric environment and provide the required release of a biologic in intestine without any untoward effects on protein conformation during processing or after release.

Functionalized Mesoporous Silica Particles for Application in Drug Delivery System

2012 ◽  
Vol 12 (8) ◽  
pp. 775-788 ◽  
Author(s):  
J. Pang ◽  
Y. Luan ◽  
X. Yang ◽  
Y. Jiang ◽  
L. Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Silica Particles ◽  
Functionalized Mesoporous Silica

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles

2019 ◽  
Author(s):  
Teodora Popova ◽  
Borislav Tzankov ◽  
Christina Voycheva ◽  
Krassimira Yoncheva ◽  
Nikolai Lambov
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Silica Particles

Evaluation of Potential of Uncoated Mesoporous Silica Particles for Drug Delivery Applications

2021 ◽  
Vol 875 ◽  
pp. 366-372
Author(s):  
Tayyab Ali Khan ◽  
Syed Mujtaba Ul Hassan ◽  
Hassan Waqas ◽  
Jamil Ahmad ◽  
Ahmat Khurshid ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Loading ◽  
Sol Gel ◽  
Cancer Cell Line ◽  
Silica Particles ◽  
Atomic Force ◽  
Drug Delivery Applications ◽  
Model Drug ◽  
Average Size

The drug loading capability and inherent cytotoxicity of mesoporous silica particles are two prime considerations for targeted drug delivery applications. In current study, uncoated mesoporous silica (UMS) carrier particles were synthesized by sol-gel emulsion approach. The morphology and structure of UMS was thoroughly characterized using atomic force microscope (AFM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Brunauer–Emmett–Teller (BET). The scanning electron microscopy (SEM) and dynamic light scattering (DLS) measurements reveal that mono dispersed silica particles have an average size of 250 nm with narrow size distribution. The pore size was measured as 47nm. Concentration dependent biocompatibility of UMS was evaluated using MTT assay with Hep-2c cancer cell line and cell viability of ~65% at concentrations of 7.5 nM was observed. Finally, the drug loading capability of UMS carrier was studied using ibuprofen as a model drug.

scholarly journals Feasibility Study of Mesoporous Silica Particles for Pulmonary Drug Delivery: Therapeutic Treatment with Dexamethasone in a Mouse Model of Airway Inflammation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 149 ◽  
Author(s):  
Tina Gulin-Sarfraz ◽  
Sofia Jonasson ◽  
Elisabeth Wigenstam ◽  
Eva von Haartman ◽  
Anders Bucht ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Airway Inflammation ◽  
Local Treatment ◽  
Drug Carriers ◽  
Silica Particles ◽  
Therapeutic Modality ◽  
Porous Carrier ◽  
Poorly Soluble ◽  
Aqueous Dispersibility

Diseases in the respiratory tract rank among the leading causes of death in the world, and thus novel and optimized treatments are needed. The lungs offer a large surface for drug absorption, and the inhalation of aerosolized drugs are a well-established therapeutic modality for local treatment of lung conditions. Nanoparticle-based drug delivery platforms are gaining importance for use through the pulmonary route. By using porous carrier matrices, higher doses of especially poorly soluble drugs can be administered locally, reducing their side effects and improving their biodistribution. In this study, the feasibility of mesoporous silica particles (MSPs) as carriers for anti-inflammatory drugs in the treatment of airway inflammation was investigated. Two different sizes of particles on the micron and nanoscale (1 µm and 200 nm) were produced, and were loaded with dexamethasone (DEX) to a loading degree of 1:1 DEX:MSP. These particles were further surface-functionalized with a polyethylene glycol–polyethylene imine (PEG–PEI) copolymer for optimal aqueous dispersibility. The drug-loaded particles were administered as an aerosol, through inhalation to two different mice models of neutrophil-induced (by melphalan or lipopolysaccharide) airway inflammation. The mice received treatment with either DEX-loaded MSPs or, as controls, empty MSPs or DEX only; and were evaluated for treatment effects 24 h after exposure. The results show that the MEL-induced airway inflammation could be treated by the DEX-loaded MSPs to the same extent as free DEX. Interestingly, in the case of LPS-induced inflammation, even the empty MSPs significantly down-modulated the inflammatory response. This study highlights the potential of MSPs as drug carriers for the treatment of diseases in the airways.

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