CuS@mSiO2-PEG core–shell nanoparticles as a NIR light responsive drug delivery nanoplatform for efficient chemo-photothermal therapy

2015 ◽  
Vol 44 (22) ◽  
pp. 10343-10351 ◽  
Author(s):  
Xijian Liu ◽  
Qilong Ren ◽  
Fanfan Fu ◽  
Rujia Zou ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Nir Light ◽  
Core Shell Nanoparticles

A difunctional nanoplatform (CuS@mSiO2-PEG) acted as a NIR light induced photothermal-triggered drug delivery system for efficient chemo-photothermal therapy.

Formation of Core/Shell Nanoparticles with a Lipid Core and Their Application as a Drug Delivery System

2005 ◽  
Vol 6 (2) ◽  
pp. 1062-1067 ◽  
Author(s):  
Keun Sang Oh ◽  
Kyung Eun Lee ◽  
Sung Sik Han ◽  
Sun Hang Cho ◽  
Dongmin Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Lipid Core ◽  
Core Shell Nanoparticles

scholarly journals Core–Shell Nanoparticles as an Efficient, Sustained, and Triggered Drug-Delivery System

ACS Omega ◽  
2017 ◽  
Vol 2 (10) ◽  
pp. 6455-6463 ◽  
Author(s):  
Sonal Deshpande ◽  
Sapna Sharma ◽  
Veena Koul ◽  
Neetu Singh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Thrombolysis Combined Therapy Using CuS@SiO2-PEG/uPA Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Dapeng Fu ◽  
Qingbo Fang ◽  
Fukang Yuan ◽  
Junle Liu ◽  
Heyi Ding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Combined Therapy ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Massive hemorrhage caused by the uncontrolled release of thrombolysis drugs is a key issue of thrombolysis therapy in clinical practice. In this study, we report a near-infrared (NIR) light-triggered drug delivery system, i.e., CuS@mSiO2-PEG (CSP) nanoparticles, for the loading of a thrombolytic drug (urokinase plasminogen activators, uPA). CSP nanoparticles with the CuS nanoparticles as photothermal agents and mesoporous SiO2 for the loading of uPA were synthesized using a facile hydrothermal method. The CSP core-shell nanoparticles were demonstrated to possess excellent photothermal performance, exhibiting a photothermal conversion efficiency of up to 52.8%. Due to the mesoporous SiO2 coating, the CSP core-shell nanoparticles exhibited appropriate pore size, high pore volume, and large surface area; thus, they showed great potential to be used as drug carriers. Importantly, the release of uPA from CuS@mSiO2-PEG/uPA (CSPA) carriers can be promoted by the NIR laser irradiation. The drug loading content of uPA for the as-prepared NIR-triggered drug delivery system was calculated to be 8.2%, and the loading efficiency can be determined to be as high as 89.6%. Due to the excellent photothermal effect of CSP nanocarriers, the NIR-triggered drug delivery system can be used for infrared thermal imaging in vivo. The in vivo thrombolysis assessment demonstrated that the NIR-triggered drug delivery system showed excellent thrombolytic ability under the irradiation of an 808 nm laser, showing the combined therapy for thrombolysis. As far as we know, the CSPA core-shell nanoparticles used as NIR-triggered drug delivery systems for thrombolysis have not been reported.

tLyP-1–Conjugated Au-Nanorod@SiO2 Core–Shell Nanoparticles for Tumor-Targeted Drug Delivery and Photothermal Therapy

Langmuir ◽  
2014 ◽  
Vol 30 (26) ◽  
pp. 7789-7797 ◽  
Author(s):  
Baiyao Xu ◽  
Yang Ju ◽  
Yanbin Cui ◽  
Guanbin Song ◽  
Yuichi Iwase ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Targeted Drug ◽  
Core Shell Nanoparticles

Cu2−xSe@mSiO2–PEG core–shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4361-4370 ◽  
Author(s):  
Xijian Liu ◽  
Qian Wang ◽  
Chun Li ◽  
Rujia Zou ◽  
Bo Li ◽  
...  
Keyword(s):  
Power Density ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Light Radiation ◽  
Shell Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Core Shell Nanoparticles

A difunctional nanoplatform based on the Cu2−xSe@mSiO2–PEG core–shell nanoparticles demonstrates an excellent biocompatibility and can be used for combining photothermal- and chemotherapies driven by NIR light.

Polypyrrole coated PLGA core–shell nanoparticles for drug delivery and photothermal therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84269-84275 ◽  
Author(s):  
Ming Liu ◽  
Na Xu ◽  
Wensen Liu ◽  
Zhigang Xie
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Core–shell PLGA@polypyrrole nanoparticls (PLGA@PPy NPS) were prepared for combination of photothermal therapy and chemotherapy.

Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

2013 ◽  
Vol 20 (28) ◽  
pp. 3488-3499 ◽  
Author(s):  
Yon Jung ◽  
Hwanbum Lee ◽  
Jae Kim ◽  
Eun Koo ◽  
Keun Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

NIR-triggered drug delivery system based on Fe3O4-MoS2 core-shell grafted poly(N-vinylcaprolactam): isotherm and kinetics studies

2021 ◽  
pp. 1-15
Author(s):  
Mohammad Javad Khodabakhshi ◽  
Homayon Ahmad Panahi ◽  
Elaheh Konoz ◽  
Alireza Feizbakhsh ◽  
Salimeh Kimiagar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Shell ◽  
Kinetics Studies
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