Computational methods for the description of pharmacologically relevant platinum complexes – molecular structure and bond dissociation

2016 ◽  
Vol 18 (5) ◽  
pp. 4051-4062 ◽  
Author(s):  
Malte Kokoschka ◽  
Jakub Galgonek ◽  
Jiri Vondrasek ◽  
Pavel Hobza
Keyword(s):  
Molecular Structure ◽  
Cardiovascular Disease ◽  
Cause Of Death ◽  
Computational Methods ◽  
Platinum Complexes ◽  
Bond Dissociation

Cancer is after cardiovascular disease the most frequent cause of death in Europe.

scholarly journals Cardioinformatics: the nexus of bioinformatics and precision cardiology

2019 ◽  
Author(s):  
Bohdan B Khomtchouk ◽  
Diem-Trang Tran ◽  
Kasra A Vand ◽  
Matthew Might ◽  
Or Gozani ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Research ◽  
Computational Biology ◽  
Cause Of Death ◽  
Cancer Mortality ◽  
Unmet Need ◽  
Mortality Rates ◽  
Cardiovascular Medicine ◽  
Biology Research

Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17 million deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, most bioinformatics and computational biology research and funding to date has been concentrated predominantly on cancer research, with a relatively modest footprint in CVD. In this paper, we review the existing literary landscape and critically assess the unmet need to further develop an emerging field at the multidisciplinary interface of bioinformatics and precision cardiovascular medicine, which we refer to as ‘cardioinformatics’.

Subclinical Hypothyroidism as a Risk Factor for Cardiovascular Disease

2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cause Of Death ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Epidemiological Studies ◽  
Cardiovascular Disorders ◽  
The World

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism

scholarly journals Sudden cardiac death rates in an Australian population: a data linkage study

2015 ◽  
Vol 39 (5) ◽  
pp. 561 ◽  
Author(s):  
Jia-Li Feng ◽  
Siobhan Hickling ◽  
Lee Nedkoff ◽  
Matthew Knuiman ◽  
Christopher Semsarian ◽  
...  
Keyword(s):  
Public Health ◽  
Cardiovascular Disease ◽  
Heart Disease ◽  
Sudden Cardiac Death ◽  
Cause Of Death ◽  
Cardiac Death ◽  
Linkage Study ◽  
Mortality Data ◽  
Prevention Measures ◽  
Hospital Morbidity

Objective The aim of the present study was to develop criteria to identify sudden cardiac death (SCD) and estimate population rates of SCD using administrative mortality and hospital morbidity records in Western Australia. Methods Four criteria were developed using place, death within 24 h, principal and secondary diagnoses, underlying and associated cause of death, and/or occurrence of a post mortem to identify SCD. Average crude, age-standardised and age-specific rates of SCD were estimated using population person-linked administrative data. Results In all, 9567 probable SCDs were identified between 1997 and 2010, with one-third aged ≥35 years having no prior admission for cardiovascular disease. SCD was more frequent in men (62.1%). The estimated average annual crude SCD rate for the period was 34.6 per 100 000 person-years with an average annual age-standardised rate of 37.8 per 100 000 person-years. Age-specific standardised rates were 1.1 per 100 000 person-years and 70.7 per 100 000 person-years in people aged 1–34 and ≥35 years, respectively. Ischaemic heart disease (IHD) was recorded as the underlying cause of death in approximately 80% of patients aged ≥35 years, followed by valvular heart disease and heart failure. IHD was the most common cause of death in those aged 1–34 years, followed by unspecified cardiomyopathy and dysrhythmias. Conclusions Administrative morbidity and mortality data can be used to estimate rates of SCD and therefore provide a suitable methodology for monitoring SCD over time. The findings highlight the magnitude of SCD and its potential for public health prevention. What is known about the topic? There is considerable variability in rates of SCD worldwide. Different data sources and varied methods of case ascertainment likely contribute to this variation. What does this paper add? The rate of SCD in Australia is low compared with international estimates from USA, Ireland, Netherlands and China. Two in every three cases of SCD aged ≥35 years had a hospitalisation history of cardiovascular disease, highlighting the opportunity for prevention. What are the implications for practitioners? High-quality person-linked administrative hospital morbidity and registered mortality data can be used to estimate rates of SCD in the population. Understanding the magnitude and distribution of SCD is imperative for developing effective public health policy and prevention measures.

scholarly journals KEMATIAN MENDADAK KARDIOVASKULER

2017 ◽  
Vol 17 (2) ◽  
pp. 112-118
Author(s):  
Taufik Suryadi
Keyword(s):  
Cardiovascular Disease ◽  
Sudden Death ◽  
Emergency Room ◽  
Cardiovascular System ◽  
Cause Of Death ◽  
Medical Personnel ◽  
External Examination

Abstrak. Kematian mendadak merupakan kematian yang terjadi pada 24 jam sejak gejala-gejala timbul, namun pada kasus-kasus forensik sebagian besar kematian terjadi   dalam   hitungan   menit   bahkan   detik   sejak   gejala   pertama   timbul. Dilaporkan laki-laki berusia 42 tahun   meninggal secara mendadak setelah mengalami kejang-kejang dan tidak sadarkan diri. Setelah dilakukan pemeriksaan oleh tenaga medis di Instalasi Gawat Darurat (IGD), pasien dinyatakan Death on Arrival (DOA). Dari hasil pemeriksaan luar dijumpai bintik kemerahan pada kelopak mata bagian dalam serta warna kebiruan pada ujung jari tangan dan kaki tanda-tanda terjadinya asfiksia. Sebab kematian adalah akibat kegagalan sistem kardiovaskuler yang terjadi secara mendadak. (JKS 2017; 2: 115-122)Kata kunci : Kematian mendadak, penyakit kardiovaskuler, aspek medikolegalAbstract. Sudden death is a death that occurred in the 24 hour  since symptoms arise, but in cases of forensic most deaths occur within minutes if not seconds since the first symptoms arise. Reported men aged 42 years died suddenly after suffering convulsions and unconsciousness. After examination by medical personnel  in  the  emergency  room,  the  patient  is  declared  Death  on  Arrival (DOA). From the results of external examination found red spots on the inside of the eyelid and a bluish color on the tip of the fingers and toes signs of asphyxia. Cause of death was due to failure of the cardiovascular system that occurs suddenly.(JKS 2017; 2: 115-122)Keywords: Sudden death, cardiovascular disease, medicolegal aspect;

scholarly journals Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration

2021 ◽  
Vol 9 ◽  
Author(s):  
Stefan Elde ◽  
Hanjay Wang ◽  
Y. Joseph Woo
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Trials ◽  
Cell Therapy ◽  
Cause Of Death ◽  
Natural Regeneration ◽  
Therapeutic Potential ◽  
Myocardial Regeneration ◽  
Heart Regeneration ◽  
Recent Developments

Cardiovascular disease remains the leading cause of death worldwide despite significant advances in our understanding of the disease and its treatment. Consequently, the therapeutic potential of cell therapy and induction of natural myocardial regeneration have stimulated a recent surge of research and clinical trials aimed at addressing this challenge. Recent developments in the field have shed new light on the intricate relationship between inflammation and natural regeneration, an intersection that warrants further investigation.

scholarly journals Empowering Family Awareness of Cardiovascular Disease in Ngangkrik Hamlet, Sleman Regency

2021 ◽  
Vol 7 (2) ◽  
pp. 137
Author(s):  
Erinda Nurrahma ◽  
Ailsa Nur Rahma Apta Widyadhana ◽  
Annisa Leny Saraswati ◽  
Ave Anugraheni ◽  
Muhammad Jourdan Prasetyatama ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Primary Prevention ◽  
Community Service ◽  
Cause Of Death ◽  
Public Awareness ◽  
Program Planning ◽  
Prevention And Treatment ◽  
Cardiovascular Care ◽  
Prevention Of Cardiovascular Disease ◽  
Special Region

Cardiovascular disease is the main cause of death worldwide and in Indonesia. Public awareness and acceptance of preventative cardiovascular care are crucial for reducing illness-related morbidity and mortality. As a result, community service is essential for the primary prevention of cardiovascular disease. Between April and July 2019, this community service was undertaken in Ngangkrik Hamlet, Sleman Regency, Yogyakarta Special Region (DIY). Ngangkrik locals participated in this program in three categories: Bapak Bijak (Wise Dads), Ibu Cerdas (Smart Moms), and Pemuda Bijak (Wise Youngsters). Five stages comprised this program: planning, informing, preparation, implementation, and oversight. Lectures/courses, discussions, practice, and roleplaying were used to implement the materials. To examine participants' knowledge, the pretest and posttest approach was utilized. The program raised participants' knowledge and understanding about the prevention and treatment of cardiovascular disease across all categories.

scholarly journals Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link

2020 ◽  
Vol 21 (14) ◽  
pp. 4822
Author(s):  
Arvand Asghari ◽  
Michihisa Umetani
Keyword(s):  
United States ◽  
Cardiovascular Disease ◽  
Estrogen Receptor ◽  
Risk Factor ◽  
Cause Of Death ◽  
The United States ◽  
Missing Link ◽  
Receptor Modulator ◽  
Obesity And Cancer

Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States. Cancer follows as the second deadliest disease, and a link between obesity and cancer has been suggested. However, it is very hard to establish an exact connection between obesity and cancers due to the multifactorial nature of obesity. Hypercholesterolemia is a comorbidity of obesity and also linked to several cancers. Recently a cholesterol metabolite 27-hydroxycholesterol (27HC) was found to be an endogenous selective estrogen receptor modulator (SERM), which opened new doors toward several interesting studies on the role of this molecule in biological disorders. It is speculated that 27HC might be the missing link in the obesity and cancer chain. Here, we explored the effects of 27-hydroxycholesterol on obesity and cancers with a focus on the SERM capacity of 27HC.

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