Surface-enhanced Raman scattering imaging of cancer cells and tissues via sialic acid-imprinted nanotags

2015 ◽  
Vol 51 (100) ◽  
pp. 17696-17699 ◽  
Author(s):  
Danyang Yin ◽  
Shuangshou Wang ◽  
Yunjie He ◽  
Jia Liu ◽  
Min Zhou ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Sialic acid-imprinted nanotags were designed and synthesized for surface-enhanced Raman scattering for imaging of cancer cells and tissues.

scholarly journals Controlled release of targeted anti-leukemia drugs azacitidine and decitabine monitored using surface-enhanced Raman scattering (SERS) spectroscopy

2017 ◽  
Vol 6 (4) ◽  
pp. 125-132 ◽  
Author(s):  
Madison Smith ◽  
Maria Hepel
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A new targeted drug delivery system with controlled release of anti-cancer drugs, azacitidine and decitabine, was investigated to enhance the efficacy of cancer treatment and reduce the effects of high drug toxicity to healthy tissues. The proposed drug nanocarriers are based on gold nanoparticles (AuNPs) modified with mercaptobenzoic acid (MBA) linker to enable the immobilization of azacitidine (AZA) and decitabine (DAC) on AuNPs in the form of AuNP@MBA/AZA,DAC entities. The cancer cell recognition was accomplished by covalently binding folic acid (FA) ligands to para-aminothiophenol (PATP) in the mixed SAM shell on gold nanoparticle nanocarriers, AuNP@MBA,PATP. The FA ligand was used due to the strong expression of folic acid receptors (FR) in the membrane of cancer cells. This enables the functionalized carriers to target only cancer cells owing to the efficient FA-FR binding property. The amide bonds between the linkers and azacitidine/decitabine are pH sensitive and undergo acid hydrolysis in a low pH environment of the cytosol in cancer cells. Using the solutions of different pH, the release of azacitidine/decitabine was monitored by surface-enhanced Raman scattering spectroscopy (SERS) measurements of the MBA Raman modes at 1586 cm-1 and 1074 cm-1 . At pH 7.4, the release of the drug was found to be negligible, while at pH 4.0 and 5.5 a continuous drug release was observed over 3 hours. The utilization of SERS monitoring for the drug release was based on the strong Raman signals which are generated by the MBA linker when it is bound to a plasmonic AuNP. During the immobilization of azacitidine/decitabine on AuNP carriers, the SERS signals are strongly reduced due to the shielding by drug molecules but they increase sharply upon the drug release confirming the amide bond breakage and successful drug delivery.

scholarly journals Self-assembled nanoporous graphene quantum dot-Mn3O4 nanocomposites for surface-enhanced Raman scattering based identification of cancer cells

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18658-18667 ◽  
Author(s):  
Chuanqing Lan ◽  
Jingjin Zhao ◽  
Liangliang Zhang ◽  
Changchun Wen ◽  
Yong Huang ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Nano Composite ◽  
Graphene Quantum Dot ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Nanoporous Graphene ◽  
Enhanced Raman Scattering

A nanoporous graphene quantum dot-Mn3O4 nano-composite was synthesized, and used as a new platform for surface-enhanced Raman scattering-based identification of cancer cells.

Surface-Enhanced Raman Scattering Optophysiology Nanofibers for the Detection of Heavy Metals in Single Breast Cancer Cells

ACS Sensors ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 1649-1662
Author(s):  
Xingjuan Zhao ◽  
Shirley Campbell ◽  
Patrick Z. El-Khoury ◽  
Yuechen Jia ◽  
Gregory Q. Wallace ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Heavy Metals ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Silica-coated dimers of silver nanospheres as surface-enhanced Raman scattering tags for imaging cancer cells

2013 ◽  
Vol 3 (3) ◽  
pp. 20120092 ◽  
Author(s):  
Xiaohu Xia ◽  
Weiyang Li ◽  
Yu Zhang ◽  
Younan Xia
Keyword(s):  
Raman Scattering ◽  
Cancer Cells ◽  
Hot Spot ◽  
High Sensitivity ◽  
Silica Coating ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Sers Tags

Surface-enhanced Raman scattering (SERS) tags have been actively explored as a multiplexing platform for sensitive detection of biomolecules. Here, we report a new type of SERS tags that was fabricated by sequentially functionalizing dimers made of 50 nm Ag nanospheres with 4-mercaptobenzoic acid as the Raman reporter molecule, silica coating as a protective shell and antibody as a targeting ligand. These dimer-based tags give highly enhanced and reproducible Raman signals owing to the presence of a well-defined SERS hot spot at the junction between two Ag nanospheres in the dimer. The SERS enhancement factor (EF) of an individual dimer tag supported on a glass slide can reach a level as high as 4.3 × 10 6 . In comparison, the EFs dropped to 2.8 × 10 5 and 8.7 × 10 5 , respectively, when Ag nanospheres and nanocubes with sizes similar to the spheres in the dimer were used to fabricate the tags using similar procedures. The SERS signals from aqueous suspensions of the dimer-based tags also showed high intensity and good stability. Potential use of the dimer-based tags was demonstrated by imaging cancer cells overexpressing HER2 receptors with good specificity and high sensitivity.

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