Surface Enhanced Raman Scattering Probes Based on Antibody Conjugated Au Nanostars for Distinguishing Lung Cancer Cells from Normal Cells

2016 ◽  
Vol 16 (12) ◽  
pp. 12161-12171 ◽  
Author(s):  
Xiaowei Cao ◽  
Chaowen Shi ◽  
Wenbo Lu ◽  
Hang Zhao ◽  
Man Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Lung Cancer Cells ◽  
Normal Cells ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Controlled release of targeted anti-leukemia drugs azacitidine and decitabine monitored using surface-enhanced Raman scattering (SERS) spectroscopy

2017 ◽  
Vol 6 (4) ◽  
pp. 125-132 ◽  
Author(s):  
Madison Smith ◽  
Maria Hepel
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Controlled Release ◽  
Drug Release ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A new targeted drug delivery system with controlled release of anti-cancer drugs, azacitidine and decitabine, was investigated to enhance the efficacy of cancer treatment and reduce the effects of high drug toxicity to healthy tissues. The proposed drug nanocarriers are based on gold nanoparticles (AuNPs) modified with mercaptobenzoic acid (MBA) linker to enable the immobilization of azacitidine (AZA) and decitabine (DAC) on AuNPs in the form of AuNP@MBA/AZA,DAC entities. The cancer cell recognition was accomplished by covalently binding folic acid (FA) ligands to para-aminothiophenol (PATP) in the mixed SAM shell on gold nanoparticle nanocarriers, AuNP@MBA,PATP. The FA ligand was used due to the strong expression of folic acid receptors (FR) in the membrane of cancer cells. This enables the functionalized carriers to target only cancer cells owing to the efficient FA-FR binding property. The amide bonds between the linkers and azacitidine/decitabine are pH sensitive and undergo acid hydrolysis in a low pH environment of the cytosol in cancer cells. Using the solutions of different pH, the release of azacitidine/decitabine was monitored by surface-enhanced Raman scattering spectroscopy (SERS) measurements of the MBA Raman modes at 1586 cm-1 and 1074 cm-1 . At pH 7.4, the release of the drug was found to be negligible, while at pH 4.0 and 5.5 a continuous drug release was observed over 3 hours. The utilization of SERS monitoring for the drug release was based on the strong Raman signals which are generated by the MBA linker when it is bound to a plasmonic AuNP. During the immobilization of azacitidine/decitabine on AuNP carriers, the SERS signals are strongly reduced due to the shielding by drug molecules but they increase sharply upon the drug release confirming the amide bond breakage and successful drug delivery.

scholarly journals Self-assembled nanoporous graphene quantum dot-Mn3O4 nanocomposites for surface-enhanced Raman scattering based identification of cancer cells

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18658-18667 ◽  
Author(s):  
Chuanqing Lan ◽  
Jingjin Zhao ◽  
Liangliang Zhang ◽  
Changchun Wen ◽  
Yong Huang ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Raman Scattering ◽  
Cancer Cells ◽  
Surface Enhanced Raman Scattering ◽  
Nano Composite ◽  
Graphene Quantum Dot ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Nanoporous Graphene ◽  
Enhanced Raman Scattering

A nanoporous graphene quantum dot-Mn3O4 nano-composite was synthesized, and used as a new platform for surface-enhanced Raman scattering-based identification of cancer cells.

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