scholarly journals PLA2-responsive and SPIO-loaded phospholipid micelles

2015 ◽  
Vol 51 (61) ◽  
pp. 12313-12315 ◽  
Author(s):  
Qiang Gao ◽  
Lesan Yan ◽  
Michael Chiorazzo ◽  
E. James Delikatny ◽  
Andrew Tsourkas ◽  
...  

PLA2-responsive and superparamagnetic iron oxide (SPIO) nanoparticle-loaded phospholipid micelles were developed. The release of a phospholipid-conjugated dye from these micelles was triggered due to phospholipid degradation by phospholipase A2. The high relaxivity of the encapsulated SPIO could enable non-invasive magnetic resonance imaging.

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