scholarly journals Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: Clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging

2004 ◽  
Vol 20 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Martin Rausch ◽  
Peter Hiestand ◽  
Carolyn A. Foster ◽  
Diana R. Baumann ◽  
Catherine Cannet ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Superparamagnetic Iron Oxide ◽  
Clinical Implications ◽  
Resonance Imaging ◽  
Autoimmune Encephalomyelitis ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Experimental Autoimmune

scholarly journals Targeted Molecular Magnetic Resonance Imaging Detects Brown Adipose Tissue with Ultrasmall Superparamagnetic Iron Oxide

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Qingqiao Hu ◽  
Xiangxun Chen ◽  
Juan Liu ◽  
Wenjuan Di ◽  
Shan Lv ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Adipose Tissue ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Brown Adipose Tissue ◽  
Superparamagnetic Iron Oxide ◽  
Resonance Imaging ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Brown Adipose

The peptide (CKGGRAKDC-NH2) specifically targets the brown adipose tissue (BAT). Here we applied this peptide coupled with polyethylene glycol (PEG)-coated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles to detect BAT in vivo by magnetic resonance imaging (MRI). The peptide was conjugated with PEG-coated USPIO nanoparticles to obtain targeted USPIO nanoprobes. Then the nanoprobes for BAT were evaluated in mice. T2⁎-weighted images were performed, precontrast and postcontrast USPIO nanoparticles. Finally, histological analyses proved the specific targeting. The specificity of targeted USPIO nanoprobes was observed in mice. The T2⁎ relaxation time of BAT in the targeted group decreased obviously compared to the controls (P<0.001). Prussian blue staining and transmission electron microscope confirmed the specific presence of iron oxide. This study demonstrated that peptide (CKGGRAKDC-NH2) coupled with PEG-coated USPIO nanoparticles could identify BAT noninvasively in vivo with MRI.

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