A selective decoy–doxorubicin complex for targeted co-delivery, STAT3 probing and synergistic anti-cancer effect

2015 ◽  
Vol 51 (68) ◽  
pp. 13309-13312 ◽  
Author(s):  
Shao-Jen Wang ◽  
Yung-Te Hou ◽  
Lin-Chi Chen
Keyword(s):  
Anti Cancer ◽  
Cancer Theranostics

A novel selective decoy oligodeoxynucleotide (dODN)–doxorubicin (DOX) complex is reported for cancer theranostics.

Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

2020 ◽  
Vol 20 (11) ◽  
pp. 1340-1351 ◽  
Author(s):  
Ponnurengam M. Sivakumar ◽  
Matin Islami ◽  
Ali Zarrabi ◽  
Arezoo Khosravi ◽  
Shohreh Peimanfard
Keyword(s):  
Mechanical Stability ◽  
Chemical Properties ◽  
The Other ◽  
Hydrophilic Polymer ◽  
Two Dimensional ◽  
Normal Tissues ◽  
Physical Chemical ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical-chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, superconductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties have been introduced as an efficient approach to improve the properties of graphene-based nanomaterials and obtain new nanoassemblies for cancer therapy. Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymergraphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies. Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated a reduction of the side effects of anti-cancer drugs for normal tissues.

An optimized lanthanide-chlorophyll nanocomposite for dual-modal imaging-guided surgery navigation and anti-cancer theranostics

2020 ◽  
Vol 8 (5) ◽  
pp. 1270-1278 ◽  
Author(s):  
Yanxing Wang ◽  
Wei-Dong Lü ◽  
Bi Lin ◽  
Fan Yang ◽  
Miao Feng ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Red Emission ◽  
Guided Surgery ◽  
Anti Cancer ◽  
Cancer Theranostics

A lanthanide-chlorophyll nanocomposite with enhanced red emission under a near-infrared laser was designed for dual-modal imaging-guided surgery navigation and anti-cancer theranostics.

Facile design of thio-perylenediimides with controllable fluorescent, photodynamic and photothermal effects towards cancer theranostics

2021 ◽  
Author(s):  
Chang Liu ◽  
Chendong Ji ◽  
Zongyang Fan ◽  
Ruihao Ma ◽  
Meizhen Yin
Keyword(s):  
One Pot ◽  
Tert Butyl ◽  
Anti Cancer ◽  
Butyl Phenol ◽  
Photothermal Effects ◽  
Cancer Theranostics

A series of thionated perylenediimides with modulating phototheranostic modalities have been synthesized by one-pot method for multiple anti-cancer applications. Compared to the initial and 4-tert-butyl phenol-substituted fluorescent perylenediimide, the obtained...

MoS2–ZnO nanocomposites as highly functional agents for anti-angiogenic and anti-cancer theranostics

2018 ◽  
Vol 6 (19) ◽  
pp. 3048-3057 ◽  
Author(s):  
Levna Chacko ◽  
Aswini Poyyakkara ◽  
V. B. Sameer Kumar ◽  
P. M. Aneesh
Keyword(s):  
Anti Cancer ◽  
Cancer Theranostics

Unlike the parent compounds, MoS2–ZnO nanocomposites exhibit anti-tumor and anti-angiogenesis properties.

scholarly journals Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingxue Wang ◽  
Ju Huang ◽  
Weichen Zhou ◽  
Jiawen Zhao ◽  
Qi Peng ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Contrast Agents ◽  
Therapeutic Effects ◽  
Non Invasive ◽  
Drug Nanoparticles ◽  
Theranostic Nanoparticles ◽  
Anti Cancer ◽  
Therapy Strategies ◽  
Cancer Theranostics ◽  
Dual Drug

Abstract Background Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs). Results On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusion Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics. Graphical Abstract

scholarly journals Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 91
Author(s):  
Ayushi Rai ◽  
Saba Noor ◽  
Syed Ishraque Ahmad ◽  
Mohamed F. Alajmi ◽  
Afzal Hussain ◽  
...  
Keyword(s):  
Causes Of Death ◽  
High Surface ◽  
High Surface Area ◽  
Controlled Drug Release ◽  
Cancer Therapies ◽  
Infectious Agents ◽  
Anti Cancer ◽  
Common Causes ◽  
Cancer Types ◽  
Cancer Theranostics

Cancer is one of the most common causes of death and affects millions of lives every year. In addition to non-infectious carcinogens, infectious agents contribute significantly to increased incidence of several cancers. Several therapeutic techniques have been used for the treatment of such cancers. Recently, nanotechnology has emerged to advance the diagnosis, imaging, and therapeutics of various cancer types. Nanomaterials have multiple advantages over other materials due to their small size and high surface area, which allow retention and controlled drug release to improve the anti-cancer property. Most cancer therapies have been known to damage healthy cells due to poor specificity, which can be avoided by using nanosized particles. Nanomaterials can be combined with various types of biomaterials to make it less toxic and improve its biocompatibility. Based on these properties, several nanomaterials have been developed which possess excellent anti-cancer efficacy potential and improved diagnosis. This review presents the latest update on novel nanomaterials used to improve the diagnostic and therapeutic of pathogen-associated and non-pathogenic cancers. We further highlighted mechanistic insights into their mode of action, improved features, and limitations.

Glycol chitosan assisted in situ reduction of gold on polymeric template for anti-cancer theranostics

2018 ◽  
Vol 110 ◽  
pp. 392-398 ◽  
Author(s):  
Asifkhan Shanavas ◽  
Aravind Kumar Rengan ◽  
Deepak Chauhan ◽  
Liya George ◽  
Mukti Vats ◽  
...  
Keyword(s):  
In Situ Reduction ◽  
Glycol Chitosan ◽  
Anti Cancer ◽  
Cancer Theranostics ◽  
Polymeric Template

scholarly journals The Immunomodulatory Potential of Copper and Silver Based Self-Assembled Metal Organic Biohybrids Nanomaterials in Cancer Theranostics

2021 ◽  
Vol 8 ◽  
Author(s):  
Neela Prajapati ◽  
Anik Karan ◽  
Elnaz Khezerlou ◽  
Mark A. DeCoster
Keyword(s):  
Tumor Cell ◽  
Glioma Cells ◽  
Tumor Cell Line ◽  
Nano Particles ◽  
No Production ◽  
Inflammatory Stimulus ◽  
Anti Cancer ◽  
Metal Organic ◽  
A Cell ◽  
Cancer Theranostics

Copper high aspect ratio structures (CuHARS) and silver cystine nanoparticles (AgCysNPs) are two unique micro/nano particles under study here that show extensive anti-cancer effects on a glioma tumor cell line. These micro/nano particles have shown potent toxicity in the presence of inflammatory stimulus (combination of tumor necrosis factor, [TNF] and lipo-polysaccharide, LPS). CuHARS with a concentration of 20 μg/ml uniquely increased the catalytic generation of nitric oxide (NO), an important contributor in the immune system. This NO was generated in a cell culture tumor microenvironment (TME) in the presence of 25 µM S-nitrosothiol (cysteine-NO) and the inflammatory stimulus. CuHARS increased the NO production by 68.75% when compared to untreated glioma cells with CysNO and inflammatory stimulus. The production of NO was significantly higher under similar circumstances in the case of normal primary structural cells like brain microvascular endothelial cells (BMVECs). The production of NO by BMVECs went up by 181.25% compared to glioma cells. This significant increase in the NO concentration could have added up to tumorigenesis but the anti-cancer effect of CuHARS was prominent enough to lower down the viability of glioma cells by approximately 20% and increased the metabolism of structural cells, BMVECs by approximately 200%. The immunomodulatory effect of NO in the TME under these circumstances in the presence of the novel micro/nano material, CuHARS has risen up compared to the effect of inflammatory stimulus alone. The potency and specific nature of these materials toward tumor cells may make them suitable candidates for cancer treatment. Successive treatment of CuHARS to glioma cells also proved to be an effective approach considering the decrease in the total count of cells by 11.84 fold in case of three successive treatments compared to a single dose which only decreased the cell count by 2.45 fold showing the dose-dependent increasing toxicity toward glioma cells. AgCysNPs are another potent nanomaterial which also proved its significant toxic nature toward tumor cell lines as demonstrated here, but their immunomodulatory response is still unclear and needs to be explored further.

Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29757-29768 ◽  
Author(s):  
Raja Modhugoor Devendiran ◽  
Senthil kumar Chinnaiyan ◽  
Narra Kishore Yadav ◽  
Ganesh Kumar Moorthy ◽  
Giriprasath Ramanathan ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Green Synthesis ◽  
Cancer Drug ◽  
Therapeutic System ◽  
One Pot ◽  
Anti Cancer ◽  
The One ◽  
Cancer Theranostics ◽  
Cancer Drug Delivery

The one pot aqueous green synthesis of gold nanoparticles (GNPs) decorated with folic acid and loaded with doxorubicin suitable for anti-cancer drug delivery was potentially promising as a new therapeutic system for cancer treatment.

scholarly journals Hypoxia Modulation by Dual-drug Nanoparticles for Enhanced Synergistic Sonodynamic and Starvation Therapy

2020 ◽  
Author(s):  
Jingxue Wang ◽  
Ju Huang ◽  
Weichen Zhou ◽  
Jiawen Zhao ◽  
Peng Qi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Contrast Agents ◽  
Therapeutic Effects ◽  
Non Invasive ◽  
Drug Nanoparticles ◽  
Theranostic Nanoparticles ◽  
Anti Cancer ◽  
Therapy Strategies ◽  
Cancer Theranostics ◽  
Dual Drug

Abstract Background: Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs). Results: On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H2O2) in tumor regions to produce oxygen (O2), thus enhancing synergistic therapeutic effects by accelerating the decomposition of glucose and promoting the production of cytotoxic singlet oxygen (1O2) induced by ultrasound (US) irradiation. Furthermore, the NPs can also serve as excellent photoacoustic (PA)/magnetic resonance (MR) imaging contrast agents, effectuating imaging-guided cancer treatment. Conclusion: Multifunctional MG@P NPs can effectuate the synergistic amplification effect of cancer starvation therapy and SDT by hypoxia modulation, and act as contrast agents to enhance MR/PA dual-modal imaging. Consequently, MG@P NPs might be a promising nano-platform for highly efficient cancer theranostics.

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