An optimized lanthanide-chlorophyll nanocomposite for dual-modal imaging-guided surgery navigation and anti-cancer theranostics

2020 ◽  
Vol 8 (5) ◽  
pp. 1270-1278 ◽  
Author(s):  
Yanxing Wang ◽  
Wei-Dong Lü ◽  
Bi Lin ◽  
Fan Yang ◽  
Miao Feng ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Red Emission ◽  
Guided Surgery ◽  
Anti Cancer ◽  
Cancer Theranostics

A lanthanide-chlorophyll nanocomposite with enhanced red emission under a near-infrared laser was designed for dual-modal imaging-guided surgery navigation and anti-cancer theranostics.

Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

2020 ◽  
Vol 20 (11) ◽  
pp. 1340-1351 ◽  
Author(s):  
Ponnurengam M. Sivakumar ◽  
Matin Islami ◽  
Ali Zarrabi ◽  
Arezoo Khosravi ◽  
Shohreh Peimanfard
Keyword(s):  
Mechanical Stability ◽  
Chemical Properties ◽  
The Other ◽  
Hydrophilic Polymer ◽  
Two Dimensional ◽  
Normal Tissues ◽  
Physical Chemical ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical-chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, superconductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties have been introduced as an efficient approach to improve the properties of graphene-based nanomaterials and obtain new nanoassemblies for cancer therapy. Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymergraphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies. Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated a reduction of the side effects of anti-cancer drugs for normal tissues.

scholarly journals Tunable near infrared laser

2021 ◽  
Vol 1822 (1) ◽  
pp. 012016
Author(s):  
A.G. Putilov ◽  
A.A. Antipov ◽  
A.E. Shepelev ◽  
S.M. Arakelian
Keyword(s):  
Near Infrared ◽  
Infrared Laser

scholarly journals Realizing Near‐Infrared Laser Dyes through a Shift in Excited‐State Absorption

2021 ◽  
pp. 2001947
Author(s):  
Reiko Aoki ◽  
Ryutaro Komatsu ◽  
Kenichi Goushi ◽  
Masashi Mamada ◽  
Soo Young Ko ◽  
...  
Keyword(s):  
Excited State ◽  
Near Infrared ◽  
Excited State Absorption ◽  
Infrared Laser ◽  
Laser Dyes

Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and Aged Rats

2021 ◽  
Author(s):  
Fabrízio dos Santos Cardoso ◽  
Júlio César Claudino dos Santos ◽  
Francisco Gonzalez-Lima ◽  
Bruno Henrique Silva Araújo ◽  
Rodrigo Álvaro Brandão Lopes-Martins ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Laser ◽  
Aged Rats

Unexpected Binding of Tozuleristide “Tumor Paint” to Cerebral Vascular Malformations: A Potentially Novel Application of Fluorescence-Guided Surgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
Andrew J Kobets ◽  
David Nauen ◽  
Amy Lee ◽  
Alan R Cohen
Keyword(s):  
Near Infrared ◽  
Vascular Malformations ◽  
Cns Tumors ◽  
Matrix Metalloproteinase 2 ◽  
Cerebrovascular Lesions ◽  
Cavernous Malformations ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

Abstract BACKGROUND Fluorescence-guided surgery (FGS) is under investigation as a means to improve the extent of resection for primary central nervous system (CNS) tumors. Tozuleristide, known also as “Tumor Paint,” is an investigational tumor-targeting agent covalently conjugated to a derivative of the fluorescent dye indocyanine green. OBJECTIVE To report the finding of avid intraoperative fluorescence of tozuleristide on cerebral vascular malformations. METHODS Our institution is participating in a phase 2/3 study of intraoperative near-infrared fluorescence detection of pediatric primary CNS tumors in patients receiving intravenous tozuleristide and imaged with the Canvas system. Our site enrolled 2 patients with intracranial lesions, suspected preoperatively of possibly being gliomas that proved to be cavernous vascular malformations after resection. RESULTS Each lesion had a dark blue mulberry appearance and each fluoresced avidly with tozuleristide. Each was completely resected, and the patients recovered without deficit. Pathological assessment showed cavernous angioma for both cases. Tozuleristide fluorescence is postulated to result from binding to matrix metalloproteinase-2 and annexin A2, and literature review demonstrates expression of both these ligands on multiple cerebrovascular lesions, including cavernous malformations. CONCLUSION This finding deserves further investigation to determine if tozuleristide “Tumor Paint” may have a wider role in the identification of non-neoplastic intracranial pathologies.

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