Unimolecular micelles of amphiphilic cyclodextrin-core star-like block copolymers for anticancer drug delivery

2015 ◽  
Vol 51 (87) ◽  
pp. 15768-15771 ◽  
Author(s):  
Zhigang Xu ◽  
Shiying Liu ◽  
Hui Liu ◽  
Cangjie Yang ◽  
Yuejun Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Amphiphilic Cyclodextrin

Amphiphilic star-like block copolymers form robust biocompatible unimolecular micelles that are efficient in the delivery of anticancer drugs such as doxorubicin.

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

scholarly journals Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 876
Author(s):  
Seulgi Lee ◽  
Su Jeong Song ◽  
Jeil Lee ◽  
Tai Hwan Ha ◽  
Joon Sig Choi
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Cancer Cell ◽  
Anticancer Drug ◽  
Cathepsin B ◽  
Chloride Salt ◽  
Hep G2 ◽  
Hep G2 Cells ◽  
Anticancer Drug Delivery ◽  
G2 Cells

In recent decades, several types of anticancer drugs that inhibit cancer cell growth and cause cell death have been developed for chemotherapeutic application. However, these agents are usually associated with side effects resulting from nonspecific delivery, which may induce cytotoxicity in healthy cells. To reduce the nonspecific delivery issue, nanoparticles have been successfully used for the delivery of anticancer drugs to specific target sites. In this study, a functional polymeric lipid, PEG-GLFG-K(C16)2 (PEG-GLFG, polyethylene glycol-Gly-Leu-Phe-Gly-Lys(C16)2), was synthesized to enable controlled anticancer drug delivery using cathepsin B enzyme-responsive liposomes. The liposomes composed of PEG-GLFG/DOTAP (1,2-dioleoyl-3-trimethylammonium-propane (chloride salt))/DPPC (dipalmitoylphosphatidylcholine)/cholesterol were prepared and characterized at various ratios. The GLFG liposomes formed were stable liposomes and were degraded when acted upon by cathepsin B enzyme. Doxorubicin (Dox) loaded GLFG liposomes (GLFG/Dox) were observed to exert an effective anticancer effect on Hep G2 cells in vitro and inhibit cancer cell proliferation in a zebrafish model.

NANOSTRUCTURED LIPOSOMAL SYSTEMS AS TRANSPORT AGENTS FOR ANTICANCER DRUGS

2012 ◽  
Vol 67 (3) ◽  
pp. 23-31 ◽  
Author(s):  
A. Yu. Baryshnikov
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Cancer Chemotherapy ◽  
Biological Membranes ◽  
Liposomal Formulation ◽  
Anticancer Drug Delivery ◽  
Chemical Stimuli ◽  
Physical And Chemical ◽  
Selective Accumulation

Liposomes quite recently have turned from a model of biological membranes into an object of extensive research and practical use. The versatile traits of liposomal formulation allow its' universal implementation, especially in cancer chemotherapy. The advantages of liposomal use as a carrier of an anticancer drug for its targeted selective accumulation are discussed in this article. This article contains description of new types of liposomes, differing in contents and use, such as: simple, sterically stabilized, targeted (immunoliposomes),cationic, sensitive to physical and chemical stimuli. The characteristics of liposomal systems of anticancer drug delivery designed at Blokhin Russian Oncological Scientific Centre is given in the article.

Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

2019 ◽  
Vol 15 (5) ◽  
pp. 537-549
Author(s):  
Andrii Bazylevich ◽  
Helena Tuchinsky ◽  
Eti Zigman-Hoffman ◽  
Ran Weissman ◽  
Ofer Shpilberg ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Survival ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Multiple Drug ◽  
Anticancer Drug Delivery ◽  
Biological Studies

Background: Scientists have extensively investigated curcumin, yielding many publications on treatments of cancer. Numerous derivatives of curcumin were synthesized, evaluated for their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications. Objective: We decided to exploit curcumin as a bioactive core platform for carrying anticancer drugs, which likely possesses a carboxyl moiety for potential linkage to the carrier for drug delivery. Methods: The goal of this work is to develop biolabile multifunctional curcumin platforms towards anticancer drug delivery, including determination of drug release profiling in hydrolytic media, in vitro cytotoxicity, antioxidant properties and blockage of relevant cell survival pathways. Results: We report on a facile synthesis of the bioactive multifunctional curcumin-based platforms linked to a variety of anticancer drugs like amonafide and chlorambucil, and release of the drugs in a hydrolytic environment. The leading curcumin-based platform has presented antioxidant activity similar to curcumin, but with much more potent cytotoxicity in vitro in agreement with the augmented blockage of the NF-kB cell survival pathway. Conclusion: The approach presented here may prove beneficial for bioactive curcumin-based delivery applications where multiple drug delivery is required in a consecutive and controlled mode.

scholarly journals Theranostic unimolecular micelles of highly fluorescent conjugated polymer bottlebrushes for far red/near infrared bioimaging and efficient anticancer drug delivery

2016 ◽  
Vol 7 (48) ◽  
pp. 7455-7468 ◽  
Author(s):  
Cangjie Yang ◽  
Shuo Huang ◽  
Xiaochen Wang ◽  
Mingfeng Wang
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Cancer Imaging ◽  
Anticancer Drug Delivery

Theranostic unimolecular micelles of highly fluorescent amphiphilic conjugated bottlebrushes loaded with anticancer drugs are efficient for cancer imaging and therapy.

scholarly journals Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3713
Author(s):  
Kalyan Ramesh ◽  
Avnish Kumar Mishra ◽  
Jin Kon Kim ◽  
Yeon Tae Jeong ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Critical Micellar Concentration ◽  
Anticancer Drug Delivery ◽  
Miktoarm Star ◽  
Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

Research Progress on the Nano-Delivery Systems of Antitumor Drugs

Nano LIFE ◽  
2020 ◽  
Vol 10 (01n02) ◽  
pp. 2040006 ◽  
Author(s):  
Fan Li ◽  
Xinqing Fu ◽  
Qingqing Huo ◽  
Wantao Chen
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Therapeutic Efficacy ◽  
Drug Transport ◽  
Water Solubility ◽  
Malignant Tumors ◽  
Delivery Systems ◽  
Research Progress ◽  
Anticancer Drug Delivery

To date, chemotherapy, the main treatment for malignant tumors, still fails to provide ideal therapeutic efficacy, which is deeply rooted in various physiological barriers, either temporal or spatial, to the delivering of anticancer drugs to solid tumor sites during chemotherapy. In the meantime, the therapeutic efficacy of anticancer drugs is affected by inherent cancer characteristics, drug transport, cellular uptake and other complex interactions. Recently, advances have been constantly achieved on nanoscale drug delivery systems (NDDSs) for anticancer drug delivery, driven by their excellent stability and effectiveness in improving water solubility of anticancer drugs, prolonging systemic circulation time, reducing side effects and improving anticancer effects. This paper presents an overview of the current research status and challenges in applying NDDSs to anticancer drug delivery.

Dual-responsive core-crosslinked polyphosphoester-based nanoparticles for pH/redox-triggered anticancer drug delivery

2017 ◽  
Vol 5 (20) ◽  
pp. 3771-3782 ◽  
Author(s):  
Yue Sun ◽  
Xueqiong Du ◽  
Jinlin He ◽  
Jian Hu ◽  
Mingzu Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Hydrophobic Interactions ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

The paper focuses on the preparation of biodegradable pH/redox dual-responsive core-crosslinked nanoparticles loaded with dual anticancer drugs PTX and DOX via synergetic electrostatic as well as hydrophobic interactions and their further application in tumor chemotherapy.

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