scholarly journals Cucurbit[6]uril is an ultrasensitive129Xe NMR contrast agent

2015 ◽  
Vol 51 (43) ◽  
pp. 8982-8985 ◽  
Author(s):  
Yanfei Wang ◽  
Ivan J. Dmochowski
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Nmr Methods ◽  
Molecular Contrast ◽  
Nmr Contrast Agent

A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized129Xe NMR methods.

scholarly journals Synthesis of Gadolinium Nanoparticles as a CT-Scan Contrast Agent with Pulse Laser Ablation Method

2021 ◽  
pp. 807-811
Author(s):  
Adilla Luthfia ◽  
Iis Nurhasah ◽  
Ali Khumaeni
Keyword(s):  
Laser Ablation ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ct Scan ◽  
Repetition Rate ◽  
Blood Circulation ◽  
Ablation Process ◽  
Laser Ablation Method ◽  
Negative Effect ◽  
Molecular Contrast

The use of iodine contrast agents on CT Scan clinically shows a short-term blood circulation, non-specific biodistribution and causes side effects on kidneys. Nanoparticles have a longer half-time vascular than molecular contrast agents so it can be observed for a longer time after injection. Gadolinium (Z = 64) has a higher atomic number and X-ray absorbance coefficient than iodine (Z = 53) and does not have the negative effect on kidneys. The Gd nanoparticles development as a CT Scan contrast agent has potential to give more effectiveness than iodine contrast agents. In this study, Gd nanoparticles were synthesized using pulsed laser ablation method with wavelength 1064 nm, energy 45 mJ, and pulse width 7 ns. The ablation process was carried out for 180 minutes with repetition rate of 10 Hz and 15 Hz. The formation of Gd Nanoparticles was analyzed using UV-Vis spectrophotometer and FTIR (Fourier-Transform Infrared Spectroscopy). Testing the ability of Gd nanoparticles as a contrast agent was done in the diagnosis of head and abdomen using a CT Scan GE CT Optima 580 RT type 229156-3. UV-Vis spectrophotometer analysis showed that Gd nanoparticles had high absorbance at the wavelength less than 250 nm which indicated the formation of Gd2(OH)3 compounds. The repetition rate difference in ablation process resulted in the same concentration of Gd nanoparticles with different contrasts. Repetition rate of 10 Hz produced Gd nanoparticles with HU greater than repetition rate of 15 Hz and closer to HU of iodine. The results indicate that Gd nanoparticles can be used as a CT Scan contrast agent.

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

scholarly journals Quantitative dual contrast photon-counting computed tomography for assessment of articular cartilage health

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Petri Paakkari ◽  
Satu I. Inkinen ◽  
Miitu K. M. Honkanen ◽  
Mithilesh Prakash ◽  
Rubina Shaikh ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Articular Cartilage ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Photon Counting ◽  
Spectral Imaging ◽  
Ct Scanning ◽  
Photon Counting Detector ◽  
Tissue Contrast ◽  
Reference Parameters

AbstractPhoton-counting detector computed tomography (PCD-CT) is a modern spectral imaging technique utilizing photon-counting detectors (PCDs). PCDs detect individual photons and classify them into fixed energy bins, thus enabling energy selective imaging, contrary to energy integrating detectors that detects and sums the total energy from all photons during acquisition. The structure and composition of the articular cartilage cannot be detected with native CT imaging but can be assessed using contrast-enhancement. Spectral imaging allows simultaneous decomposition of multiple contrast agents, which can be used to target and highlight discrete cartilage properties. Here we report, for the first time, the use of PCD-CT to quantify a cationic iodinated CA4+ (targeting proteoglycans) and a non-ionic gadolinium-based gadoteridol (reflecting water content) contrast agents inside human osteochondral tissue (n = 53). We performed PCD-CT scanning at diffusion equilibrium and compared the results against reference data of biomechanical and optical density measurements, and Mankin scoring. PCD-CT enables simultaneous quantification of the two contrast agent concentrations inside cartilage and the results correlate with the structural and functional reference parameters. With improved soft tissue contrast and assessment of proteoglycan and water contents, PCD-CT with the dual contrast agent method is of potential use for the detection and monitoring of osteoarthritis.

scholarly journals Study on Establishing Reference Safe Concentrations of MRI Contrast Agents for Optimized Images: Paramagnetic Gd-DTPA-BMEA and Superparamagnetic Ferucarbotran

2021 ◽  
Vol 11 (3) ◽  
pp. 1165
Author(s):  
Wen-Tien Hsiao ◽  
Yi-Hong Chou ◽  
Jhong-Wei Tu ◽  
Ai-Yih Wang ◽  
Lu-Han Lai
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
In Vitro Experiments ◽  
Mri Contrast ◽  
In Vivo Experiments ◽  
Contrast Agent Injection

The purpose of this study is to establish the minimal injection doses of magnetic resonance imaging (MRI) contrast agents that can achieve optimized images while improving the safety of injectable MRI drugs. Gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) and ferucarbotran, commonly used in clinical practice, were selected and evaluated with in vitro and in vivo experiments. MRI was acquired using T1-weighted (T1W) and T2-weighted (T2W) sequences, and the results were quantitatively analyzed. For in vitro experiments, results showed that T1W and T2W images were optimal when Gd-DTPA-bisamide (2-oxoethyl) (Gd-DTPA-BMEA) and ferucarbotran were diluted to a volume percentage of 0.6% and 0.05%; all comparisons were significant differences in grayscale statistics using one-way analysis of variance (ANOVA). For in vivo experiments, the contrast agent with optimal concentration percentages determined from in vitro experiments were injected into mice with an injection volume of 100 μL, and the images of brain, heart, liver, and mesentery before and after injection were compared. The statistical results showed that the p values of both T1W and T2W were less than 0.001, which were statistically significant. Under safety considerations for MRI contrast agent injection, optimized MRI images could still be obtained after reducing the injection concentration, which can provide a reference for the safety concentrations of MRI contrast agent injection in the future.

scholarly journals Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent

2004 ◽  
Vol 29 (17) ◽  
pp. 2016 ◽  
Author(s):  
Changhuei Yang ◽  
Laura E. L. McGuckin ◽  
John D. Simon ◽  
Michael A. Choma ◽  
Brian E. Applegate ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Contrast Agent ◽  
Optical Coherence ◽  
Molecular Contrast

scholarly journals First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

2017 ◽  
Vol 52 (7) ◽  
pp. 419-427 ◽  
Author(s):  
Martijn Smeenge ◽  
François Tranquart ◽  
Christophe K. Mannaerts ◽  
Theo M. de Reijke ◽  
Marc J. van de Vijver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Molecular Imaging ◽  
Molecular Contrast

scholarly journals Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy-enhancement

2017 ◽  
Vol 44 (11) ◽  
pp. 5949-5960 ◽  
Author(s):  
Rachel Delorme ◽  
Florence Taupin ◽  
Mélanie Flaender ◽  
Jean-Luc Ravanat ◽  
Christophe Champion ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Contrast Agents ◽  
Molecular Contrast

scholarly journals Synthesis and Research of Nanocompositions of Oxide Materials Based on Titanium Dioxide for use as Contrast Agents in Optical Coherence Tomography

2021 ◽  
pp. 325-338
Author(s):  
Artem Nikolaevich Kupriyanov ◽  
Diana Evgen’evna Fidarova ◽  
Linda Ruslanovna Makhmudova ◽  
Magomed Rasulovich Gadzhiev ◽  
Shuainat Ruslanovna Nimatulaeva ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Titanium Dioxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Elemental Composition ◽  
Zirconium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Optical Coherence ◽  
Oxide Materials ◽  
The Stability

In this paper, the contrasting properties of titanium dioxide nanoparticles in various compositions were considered. In the course of the work, methods for the synthesis of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2 and SiO2-TiO2-ZrO2 were developed; the microstructure of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2was studied; the stability of oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 was determined. The elemental composition of the oxide materials SiO2-TiO2, SiO2-ZrO2, TiO2-ZrO2and SiO2-TiO2-ZrO2 has also been studied using SEM and XRD methods. It was found that SiO2-TiO2-ZrO2 nanocomposites with content of titanium dioxide from 8 to 9.5 % and zirconium dioxide from 0.5 to 2 % are completely insoluble in a highly alkaline medium. Thus, this composition is the most optimal for use as a contrast agent in optical coherence tomography.

scholarly journals Iron(iii) chelated paramagnetic polymeric nanoparticle formulation as a next-generation T1-weighted MRI contrast agent

RSC Advances ◽  
2021 ◽  
Vol 11 (51) ◽  
pp. 32216-32226
Author(s):  
Ramesh Marasini ◽  
Sagar Rayamajhi ◽  
Anthony Moreno-Sanchez ◽  
Santosh Aryal
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Next Generation ◽  
Mri Contrast ◽  
Polymeric Nanoparticle ◽  
Nanoparticle Formulation

In pursuit of safer alternatives to Gd-based MRI contrast agents due to its toxicity and organ deposition, herein, we developed a safer and efficient clinically relevant iron(iii) chelated polymeric nanoparticle as a T1-weighted MRI contrast agent.

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