scholarly journals Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy-enhancement

2017 ◽  
Vol 44 (11) ◽  
pp. 5949-5960 ◽  
Author(s):  
Rachel Delorme ◽  
Florence Taupin ◽  
Mélanie Flaender ◽  
Jean-Luc Ravanat ◽  
Christophe Champion ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Contrast Agents ◽  
Molecular Contrast

Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy

2021 ◽  
Vol 47 (6) ◽  
pp. 1465-1474
Author(s):  
Quezia Lacerda ◽  
Mohamed Tantawi ◽  
Dennis B. Leeper ◽  
Margaret A. Wheatley ◽  
John R. Eisenbrey
Keyword(s):  
Radiation Therapy ◽  
Contrast Agents ◽  
Ultrasound Contrast Agents ◽  
Ultrasound Contrast

scholarly journals Differential structured illumination microendoscopy for in vivo imaging of molecular contrast agents

2016 ◽  
Vol 113 (39) ◽  
pp. 10769-10773 ◽  
Author(s):  
Pelham Keahey ◽  
Preetha Ramalingam ◽  
Kathleen Schmeler ◽  
Rebecca R. Richards-Kortum
Keyword(s):  
Contrast Agents ◽  
In Vivo Imaging ◽  
Fiber Optic ◽  
Adenocarcinoma In Situ ◽  
Structured Illumination ◽  
Optical Sectioning ◽  
Optical Elements ◽  
Fiber Optic System ◽  
Molecular Contrast

Fiber optic microendoscopy has shown promise for visualization of molecular contrast agents used to study disease in vivo. However, fiber optic microendoscopes have limited optical sectioning capability, and image contrast is limited by out-of-focus light generated in highly scattering tissue. Optical sectioning techniques have been used in microendoscopes to remove out-of-focus light but reduce imaging speed or rely on bulky optical elements that prevent in vivo imaging. Here, we present differential structured illumination microendoscopy (DSIMe), a fiber optic system that can perform structured illumination in real time for optical sectioning without any opto-mechanical components attached to the distal tip of the fiber bundle. We demonstrate the use of DSIMe during in vivo fluorescence imaging in patients undergoing surgery for cervical adenocarcinoma in situ. Images acquired using DSIMe show greater contrast than standard microendoscopy, improving the ability to detect cellular atypia associated with neoplasia.

Optical Active Molecules used as Molecular Contrast Agents for Enhanced Imaging

2008 ◽  
Author(s):  
G.C. Giakos ◽  
S. Atreya Paturi ◽  
K. Valluru ◽  
P. Bathini ◽  
K. Ambadipudi ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Molecular Contrast ◽  
Enhanced Imaging

P11 DEVELOPING NEW TARGETED MOLECULAR CONTRAST AGENTS FOR IMAGING INFLAMMATION OF VULNERABLE PLAQUES

2018 ◽  
Vol 114 (suppl_2) ◽  
pp. S3-S4
Author(s):  
R J Evans ◽  
J Hernández-Gil ◽  
Z Mohri ◽  
K Y Chooi ◽  
B Lavin-Plaza ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Vulnerable Plaques ◽  
Molecular Contrast

scholarly journals Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registration

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joong H. Kim ◽  
Stephen Dodd ◽  
Frank Q. Ye ◽  
Andrew K. Knutsen ◽  
Duong Nguyen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Mouse Brain ◽  
Oxide Nanoparticles ◽  
Non Invasive ◽  
T1 Map ◽  
Magnetic Resonance Imaging Mri ◽  
Molecular Contrast

AbstractMagnetic resonance imaging (MRI) is a widely used non-invasive methodology for both preclinical and clinical studies. However, MRI lacks molecular specificity. Molecular contrast agents for MRI would be highly beneficial for detecting specific pathological lesions and quantitatively evaluating therapeutic efficacy in vivo. In this study, an optimized Magnetization Prepared—RApid Gradient Echo (MP-RAGE) with 2 inversion times called MP2RAGE combined with advanced image co-registration is presented as an effective non-invasive methodology to quantitatively detect T1 MR contrast agents. The optimized MP2RAGE produced high quality in vivo mouse brain T1 (or R1 = 1/T1) map with high spatial resolution, 160 × 160 × 160 µm3 voxel at 9.4 T. Test–retest signal to noise was > 20 for most voxels. Extremely small iron oxide nanoparticles (ESIONPs) having 3 nm core size and 11 nm hydrodynamic radius after polyethylene glycol (PEG) coating were intracranially injected into mouse brain and detected as a proof-of-concept. Two independent MP2RAGE MR scans were performed pre- and post-injection of ESIONPs followed by advanced image co-registration. The comparison of two T1 (or R1) maps after image co-registration provided precise and quantitative assessment of the effects of the injected ESIONPs at each voxel. The proposed MR protocol has potential for future use in the detection of T1 molecular contrast agents.

scholarly journals Gold nanorods as molecular contrast agents in photoacoustic imaging: the promises and the caveats

2011 ◽  
Vol 6 (5) ◽  
pp. 389-400 ◽  
Author(s):  
Srirang Manohar ◽  
Constantin Ungureanu ◽  
Ton G. Van Leeuwen
Keyword(s):  
Contrast Agents ◽  
Gold Nanorods ◽  
Photoacoustic Imaging ◽  
Molecular Contrast

scholarly journals Cucurbit[6]uril is an ultrasensitive129Xe NMR contrast agent

2015 ◽  
Vol 51 (43) ◽  
pp. 8982-8985 ◽  
Author(s):  
Yanfei Wang ◽  
Ivan J. Dmochowski
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Nmr Methods ◽  
Molecular Contrast ◽  
Nmr Contrast Agent

A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized129Xe NMR methods.

scholarly journals Synthesis of Gadolinium Nanoparticles as a CT-Scan Contrast Agent with Pulse Laser Ablation Method

2021 ◽  
pp. 807-811
Author(s):  
Adilla Luthfia ◽  
Iis Nurhasah ◽  
Ali Khumaeni
Keyword(s):  
Laser Ablation ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Ct Scan ◽  
Repetition Rate ◽  
Blood Circulation ◽  
Ablation Process ◽  
Laser Ablation Method ◽  
Negative Effect ◽  
Molecular Contrast

The use of iodine contrast agents on CT Scan clinically shows a short-term blood circulation, non-specific biodistribution and causes side effects on kidneys. Nanoparticles have a longer half-time vascular than molecular contrast agents so it can be observed for a longer time after injection. Gadolinium (Z = 64) has a higher atomic number and X-ray absorbance coefficient than iodine (Z = 53) and does not have the negative effect on kidneys. The Gd nanoparticles development as a CT Scan contrast agent has potential to give more effectiveness than iodine contrast agents. In this study, Gd nanoparticles were synthesized using pulsed laser ablation method with wavelength 1064 nm, energy 45 mJ, and pulse width 7 ns. The ablation process was carried out for 180 minutes with repetition rate of 10 Hz and 15 Hz. The formation of Gd Nanoparticles was analyzed using UV-Vis spectrophotometer and FTIR (Fourier-Transform Infrared Spectroscopy). Testing the ability of Gd nanoparticles as a contrast agent was done in the diagnosis of head and abdomen using a CT Scan GE CT Optima 580 RT type 229156-3. UV-Vis spectrophotometer analysis showed that Gd nanoparticles had high absorbance at the wavelength less than 250 nm which indicated the formation of Gd2(OH)3 compounds. The repetition rate difference in ablation process resulted in the same concentration of Gd nanoparticles with different contrasts. Repetition rate of 10 Hz produced Gd nanoparticles with HU greater than repetition rate of 15 Hz and closer to HU of iodine. The results indicate that Gd nanoparticles can be used as a CT Scan contrast agent.

scholarly journals Pharmacokinetics of Single Domain Antibodies and Conjugated Nanoparticles Using a Hybrid near Infrared Method

2021 ◽  
Vol 22 (16) ◽  
pp. 8695
Author(s):  
Shiran Su ◽  
Thomas J. Esparza ◽  
Duong Nguyen ◽  
Simone Mastrogiacomo ◽  
Joong H. Kim ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Brain Mri ◽  
Single Domain ◽  
Oxide Nanoparticles ◽  
Nir Imaging ◽  
Single Domain Antibodies ◽  
Molecular Contrast

Iron oxide nanoparticles and single domain antibodies from camelids (VHHs) have been increasingly recognized for their potential uses for medical diagnosis and treatment. However, there have been relatively few detailed characterizations of their pharmacokinetics (PK). The aim of this study was to develop imaging methods and pharmacokinetic models to aid the future development of a novel family of brain MRI molecular contrast agents. An efficient near-infrared (NIR) imaging method was established to monitor VHH and VHH conjugated nanoparticle kinetics in mice using a hybrid approach: kinetics in blood were assessed by direct sampling, and kinetics in kidney, liver, and brain were assessed by serial in vivo NIR imaging. These studies were performed under “basal” circumstances in which the VHH constructs and VHH-conjugated nanoparticles do not substantially interact with targets nor cross the blood brain barrier. Using this approach, we constructed a five-compartment PK model that fits the data well for single VHHs, engineered VHH trimers, and iron oxide nanoparticles conjugated to VHH trimers. The establishment of the feasibility of these methods lays a foundation for future PK studies of candidate brain MRI molecular contrast agents.

Molecular Contrast Agents

2018 ◽  
pp. 131-184
Author(s):  
Massimo Mischi ◽  
Simona Turco ◽  
Osama I. Soliman ◽  
Folkert J. ten Cate ◽  
Hessel Wijkstra ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Molecular Contrast
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