Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan

2015 ◽  
Vol 51 (26) ◽  
pp. 5758-5761 ◽  
Author(s):  
T. Ramasamy ◽  
H. B. Ruttala ◽  
J. Y. Choi ◽  
T. H. Tran ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Polyelectrolyte Complex ◽  
Effective Combination ◽  
Highly Effective ◽  
Nanoparticle Core

We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer.

pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy

2014 ◽  
Vol 2 (37) ◽  
pp. 6324 ◽  
Author(s):  
Thiruganesh Ramasamy ◽  
Jeong Hwan Kim ◽  
Ju Yeon Choi ◽  
Tuan Hiep Tran ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Combination Chemotherapy ◽  
Polyelectrolyte Complex ◽  
Ph Sensitive ◽  
Effective Combination ◽  
Highly Effective ◽  
Complex Micelles

scholarly journals Synergistic Highly Potent Targeted Drug Combinations in Different Pheochromocytoma Models Including Human Tumor Cultures

Endocrinology ◽  
2019 ◽  
Vol 160 (11) ◽  
pp. 2600-2617 ◽  
Author(s):  
Maria Fankhauser ◽  
Nicole Bechmann ◽  
Michael Lauseker ◽  
Judith Goncalves ◽  
Judith Favier ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cell Viability ◽  
Primary Cultures ◽  
Mammalian Target Of Rapamycin ◽  
Human Tumor ◽  
The United States ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Effective Combination ◽  
Highly Effective

Abstract There are no officially approved therapies for metastatic pheochromocytomas apart from ultratrace 131I-metaiodbenzylguanidine therapy, which is approved only in the United States. We have, therefore, investigated the antitumor potential of molecular-targeted approaches in murine pheochromocytoma cell lines [monocyte chemoattractant protein (MPC)/monocyte chemoattractant protein/3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)], immortalized mouse chromaffin Sdhb−/− cells, three-dimensional pheochromocytoma tumor models (MPC/MTT spheroids), and human pheochromocytoma primary cultures. We identified the specific phosphatidylinositol-3-kinase α inhibitor BYL719 and the mammalian target of rapamycin inhibitor everolimus as the most effective combination in all models. Single treatment with clinically relevant doses of BYL719 and everolimus significantly decreased MPC/MTT and Sdhb−/− cell viability. A targeted combination of both inhibitors synergistically reduced MPC and Sdhb−/− cell viability and showed an additive effect on MTT cells. In MPC/MTT spheroids, treatment with clinically relevant doses of BYL719 alone or in combination with everolimus was highly effective, leading to a significant shrinkage or even a complete collapse of the spheroids. We confirmed the synergism of clinically relevant doses of BYL719 plus everolimus in human pheochromocytoma primary cultures of individual patient tumors with BYL719 attenuating everolimus-induced AKT activation. We have thus established a method to assess molecular-targeted therapies in human pheochromocytoma cultures and identified a highly effective combination therapy. Our data pave the way to customized combination therapy to target individual patient tumors.

scholarly journals Bovine serum albumin-loaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (49) ◽  
pp. 30717-30724 ◽  
Author(s):  
Guanjun Deng ◽  
Ting Zhu ◽  
Lihua Zhou ◽  
Jingnan Zhang ◽  
Sanpeng Li ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Combination Therapy ◽  
Serum Albumin ◽  
Cancer Treatment ◽  
Bovine Serum ◽  
Promising Strategy ◽  
Highly Effective

Chemo-photothermal combination therapy has already become a promising strategy for cancer treatment.

scholarly journals Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers

2021 ◽  
Author(s):  
Antonella Montinaro ◽  
Itziar Areso Zubiaur ◽  
Julia Saggau ◽  
Anna-Laura Kretz ◽  
Rute M. M. Ferreira ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Cells ◽  
Standard Of Care ◽  
Therapy Resistance ◽  
Treatment Modalities ◽  
Cancer Resistance ◽  
Therapeutic Approaches ◽  
Highly Effective ◽  
Drastic Increase ◽  
New Treatment

AbstractPrimary or acquired therapy resistance is a major obstacle to the effective treatment of cancer. Resistance to apoptosis has long been thought to contribute to therapy resistance. We show here that recombinant TRAIL and CDK9 inhibition cooperate in killing cells derived from a broad range of cancers, importantly without inducing detectable adverse events. Remarkably, the combination of TRAIL with CDK9 inhibition was also highly effective on cancers resistant to both, standard-of-care chemotherapy and various targeted therapeutic approaches. Dynamic BH3 profiling revealed that, mechanistically, combining TRAIL with CDK9 inhibition induced a drastic increase in the mitochondrial priming of cancer cells. Intriguingly, this increase occurred irrespective of whether the cancer cells were sensitive or resistant to chemo- or targeted therapy. We conclude that this pro-apoptotic combination therapy has the potential to serve as a highly effective new treatment option for a variety of different cancers. Notably, this includes cancers that are resistant to currently available treatment modalities.

Effective combination therapy with high concentration of Minoxidil and Carboxygas in resistant Androgenetic alopecia: Report of nine cases

2020 ◽  
Vol 19 (11) ◽  
pp. 2953-2957 ◽  
Author(s):  
Mohammad Ali Nilforooshzadeh ◽  
Elaheh Lotfi ◽  
Maryam Heidari‐Kharaji ◽  
Sara Zolghadr ◽  
Parvin Mansouri
Keyword(s):  
Combination Therapy ◽  
Androgenetic Alopecia ◽  
High Concentration ◽  
Effective Combination
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