pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy

2014 ◽  
Vol 2 (37) ◽  
pp. 6324 ◽  
Author(s):  
Thiruganesh Ramasamy ◽  
Jeong Hwan Kim ◽  
Ju Yeon Choi ◽  
Tuan Hiep Tran ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Combination Chemotherapy ◽  
Polyelectrolyte Complex ◽  
Ph Sensitive ◽  
Effective Combination ◽  
Highly Effective ◽  
Complex Micelles

Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan

2015 ◽  
Vol 51 (26) ◽  
pp. 5758-5761 ◽  
Author(s):  
T. Ramasamy ◽  
H. B. Ruttala ◽  
J. Y. Choi ◽  
T. H. Tran ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Polyelectrolyte Complex ◽  
Effective Combination ◽  
Highly Effective ◽  
Nanoparticle Core

We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer.

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

Preparation of a polyelectrolyte complex gel from chitosan and κ-carrageenan and its pH-sensitive swelling

1993 ◽  
Vol 50 (11) ◽  
pp. 2021-2025 ◽  
Author(s):  
Takaharu Sakiyama ◽  
Chia-Hong Chu ◽  
Tomoyuki Fujii ◽  
Toshimasa Yano
Keyword(s):  
Polyelectrolyte Complex ◽  
Ph Sensitive

Treatment of Metastatic Breast Cancer with Cyclophosphamide, Methotrexate, Vincristine and Fluorouracil.

1973 ◽  
Vol 59 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Mario De Lena ◽  
Giuseppe Maria De Palo ◽  
Gianni Bonadonna ◽  
Gianni Beretta ◽  
Emilio Bajetta
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Combination Chemotherapy ◽  
Metastatic Breast ◽  
Great Majority ◽  
Bone Lesions ◽  
Limiting Factor ◽  
Response Table ◽  
Effective Combination ◽  
Number Of Cycles

From November 1970 to June 1972, 55 patients with metastatic breast cancer were treated with a 4-drug combination (cyclophosphamide, Methotrexate, vincristine and fluorouracil) administered intravenously over a 5-day period (table 1). Treatment was repeated after a 2-week interval for the first 3 cycles, then after 4 weeks. Six more patients were incompletely treated but found evaluable for the toxicity study. The great majority of cases (51/55) was pretreated with radiotherapy, hormone and/or chemotherapy (table 3). The overall response rate was 69 %. Complete (CR) plus partial (PR) remissions (> 50 %) were 46 %. From this evaluation bone lesions was arbitrarily not included since recalcification occurs rarely after chemotherapy. The medium duration of CR was 8 months, that of PR 4 months (table 4). The most responsive lesions were those localized in the soft parts (75%) followed by metastases to lung (55%), pleura and liver (40%). Recalcification of bone lesions was observed in 17 % of cases (table 6). The number of cycles required to produce a regression was found proportional to the degree of response, with a mean of 2 cycles to obtain a PR and a mean of 3 cycles to obtain a CR (table 7). The longest regression was seen in patients with lung or liver involvement (table 8). The duration of the free interval was a positively correlated with the type of response (table 9). The dose limiting factor was represented by bone marrow depression which often required a dose attenuation schedule (table 10 and 11). The actuarial analysis of survival curves (fig.1) showed that patients achieving CR+PR lived longer than those with static disease or progression during combination chemotherapy (P < 0.05). It is concluded that combination chemotherapy can prolong the survival of responsive patients with metastatic breast cancer. The most effective combination can be found only through appropriate controlled clinical trials.

scholarly journals Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2553
Author(s):  
Jeffrey M. Ting ◽  
Alexander E. Marras ◽  
Joseph D. Mitchell ◽  
Trinity R. Campagna ◽  
Matthew V. Tirrell
Keyword(s):  
Ethylene Glycol ◽  
Polyelectrolyte Complex ◽  
Serum Proteins ◽  
Raft Polymerization ◽  
Sodium Acrylate ◽  
Structure Property ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Complex Micelles

A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized a well-defined diblock polyelectrolyte system, poly(2-methacryloyloxyethyl phosphorylcholine methacrylate)-block-poly((vinylbenzyl) trimethylammonium) (PMPC-PVBTMA), at various neutral and charged block lengths to compare directly against PCM structure–property relationships centered on poly(ethylene glycol)-block-poly((vinylbenzyl) trimethylammonium) (PEG-PVBTMA) and poly(ethylene glycol)-block-poly(l-lysine) (PEG-PLK). After complexation with a common polyanion, poly(sodium acrylate), the resulting PCMs were characterized by dynamic light scattering (DLS) and small angle X-ray scattering (SAXS). We observed uniform assemblies of spherical micelles with a diameter ~1.5–2× larger when PMPC-PVBTMA was used compared to PEG-PLK and PEG-PVBTMA via SAXS and DLS. In addition, PEG-PLK PCMs proved most resistant to dissolution by both monovalent and divalent salt, followed by PEG-PVBTMA then PMPC-PVBTMA. All micelle systems were serum stable in 100% fetal bovine serum over the course of 8 h by time-resolved DLS, demonstrating minimal interactions with serum proteins and potential as in vivo drug delivery vehicles. This thorough study of the synthesis, assembly, and characterization of zwitterionic polymers in PCMs advances the design space for charge-driven micelle assemblies.

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