Functionalizing with glycopeptide dendrimers significantly enhances the hydrophilicity of the magnetic nanoparticles

2015 ◽  
Vol 51 (19) ◽  
pp. 4093-4096 ◽  
Author(s):  
Jinan Li ◽  
Fangjun Wang ◽  
Jing Liu ◽  
Zhichao Xiong ◽  
Guang Huang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Glycopeptide Enrichment ◽  
Highly Efficient

A novel hybrid magnetic nanoparticle coated with glycopeptide dendrimers was synthesized and utilized for highly efficient N-glycopeptide enrichment.

scholarly journals An efficient multicomponent synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nanoparticle supported Lewis acidic deep eutectic solvent

RSC Advances ◽  
2019 ◽  
Vol 9 (65) ◽  
pp. 38148-38153 ◽  
Author(s):  
Thanh Thi Nguyen ◽  
Ngoc-Phuong Thi Le ◽  
The Thai Nguyen ◽  
Phuong Hoang Tran
Keyword(s):  
Magnetic Nanoparticles ◽  
Efficient Method ◽  
Magnetic Nanoparticle ◽  
Deep Eutectic Solvent ◽  
Multicomponent Synthesis ◽  
Highly Efficient ◽  
Tetrasubstituted Imidazoles

A mild and highly efficient method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a Lewis acidic deep eutectic solvent on magnetic nanoparticles (LADES@MNP).

Immobilized NNN Pd-complex on magnetic nanoparticles: efficient and reusable catalyst for Heck and Sonogashira coupling reactions

RSC Advances ◽  
2016 ◽  
Vol 6 (103) ◽  
pp. 101061-101070 ◽  
Author(s):  
Fahimeh Dehghani Firuzabadi ◽  
Zahra Asadi ◽  
Farhad Panahi
Keyword(s):  
Magnetic Nanoparticles ◽  
Palladium Catalyst ◽  
Magnetic Nanoparticle ◽  
Reusable Catalyst ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Highly Efficient ◽  
Supported Palladium Catalyst ◽  
Supported Palladium ◽  
Sonogashira Reactions

A highly efficient and easily recyclable magnetic nanoparticle supported palladium catalyst was developed and applied in the Heck and Sonogashira reactions in order to show its catalytic applicability in Pd-catalyzed C–C coupling protocols.

scholarly journals Understanding intracellular nanoparticle trafficking fates through spatiotemporally resolved magnetic nanoparticle recovery

2021 ◽  
Author(s):  
Emily Sheridan ◽  
Silvia Vercellino ◽  
Lorenzo Cursi ◽  
Laurent Adumeau ◽  
James A. Behan ◽  
...  
Keyword(s):  
Decision Making ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Magnetic Extraction

We describe how magnetic nanoparticles can be used to study intracellular nanoparticle trafficking, and how magnetic extraction may be integrated with downstream analyses to investigate nanoscale decision-making events.

scholarly journals Therapeutic Potential of Magnetic Nanoparticle-Based Human Adipose-Derived Stem Cells in a Mouse Model of Parkinson’s Disease

2021 ◽  
Vol 22 (2) ◽  
pp. 654
Author(s):  
Ka Young Kim ◽  
Keun-A Chang
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Magnetic Nanoparticles ◽  
Substantia Nigra ◽  
Mouse Model ◽  
Magnetic Nanoparticle ◽  
Imaging System ◽  
Therapeutic Potential ◽  
Adipose Derived Stem Cells

Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Several treatments for PD have focused on the management of physical symptoms using dopaminergic agents. However, these treatments induce various adverse effects, including hallucinations and cognitive impairment, owing to non-targeted brain delivery, while alleviating motor symptoms. Furthermore, these therapies are not considered ultimate cures owing to limited brain self-repair and regeneration abilities. In the present study, we aimed to investigate the therapeutic potential of human adipose-derived stem cells (hASCs) using magnetic nanoparticles in a 6-hydroxydopamine (6-OHDA)-induced PD mouse model. We used the Maestro imaging system and magnetic resonance imaging (MRI) for in vivo tracking after transplantation of magnetic nanoparticle-loaded hASCs to the PD mouse model. The Maestro imaging system revealed strong hASCs signals in the brains of PD model mice. In particular, MRI revealed hASCs distribution in the substantia nigra of hASCs-injected PD mice. Behavioral evaluations, including apomorphine-induced rotation and rotarod performance, were significantly recovered in hASCs-injected 6-OHDA induced PD mice when compared with saline-treated counterparts. Herein, we investigated whether hASCs transplantation using magnetic nanoparticles recovered motor functions through targeted brain distribution in a 6-OHDA induced PD mice. These results indicate that magnetic nanoparticle-based hASCs transplantation could be a potential therapeutic strategy in PD.

Simulated Clustering Dynamics of Colloidal Magnetic Nanoparticles

Nanoscale ◽  
2021 ◽  
Author(s):  
Frederik Laust Durhuus ◽  
Lau Halkier Wandall ◽  
Mathias Hoeg Boisen ◽  
Mathias Kure ◽  
Marco Beleggia ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Bottom Up ◽  
Novel Materials ◽  
Nanoparticle Clusters ◽  
Clustering Dynamics

Magnetically guided self-assembly of nanoparticles is a promising bottom-up method to fabricate novel materials and superstructures, such as, for example, magnetic nanoparticle clusters for biomedical applications. The existence of assembled...

scholarly journals Transient cell stiffening triggered by magnetic nanoparticle exposure

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jose E. Perez ◽  
Florian Fage ◽  
David Pereira ◽  
Ali Abou-Hassan ◽  
Sophie Asnacios ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Early Time ◽  
Population Level ◽  
Short Time Scale ◽  
Initial Contact ◽  
Almost All ◽  
The Impact ◽  
Stiffening Effect

Abstract Background The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brought into light the important role that cell mechanics play in numerous cell biological processes. However, despite the prevalence of nanotechnology applications in biology, and in particular the increased use of magnetic nanoparticles for cell therapy and imaging, the impact of nanoparticles on the cells’ mechanical properties remains poorly understood. Results Here, we used a parallel plate rheometer to measure the impact of magnetic nanoparticles on the viscoelastic modulus G*(f) of individual cells. We show how the active uptake of nanoparticles translates into cell stiffening in a short time scale (< 30 min), at the single cell level. The cell stiffening effect is however less marked at the cell population level, when the cells are pre-labeled under a longer incubation time (2 h) with nanoparticles. 24 h later, the stiffening effect is no more present. Imaging of the nanoparticle uptake reveals almost immediate (within minutes) nanoparticle aggregation at the cell membrane, triggering early endocytosis, whereas nanoparticles are almost all confined in late or lysosomal endosomes after 2 h of uptake. Remarkably, this correlates well with the imaging of the actin cytoskeleton, with actin bundling being highly prevalent at early time points into the exposure to the nanoparticles, an effect that renormalizes after longer periods. Conclusions Overall, this work evidences that magnetic nanoparticle internalization, coupled to cytoskeleton remodeling, contributes to a change in the cell mechanical properties within minutes of their initial contact, leading to an increase in cell rigidity. This effect appears to be transient, reduced after hours and disappearing 24 h after the internalization has taken place.

Magnetic Nanoparticle Arrays with Ultra-Uniform Length Electrodeposited in Highly Ordered Alumina Nanopores(“Alumite”)

2000 ◽  
Vol 636 ◽  
Author(s):  
Robert M. Metzger ◽  
Ming Sun ◽  
Giovanni Zangari ◽  
Mohammad Shamsuzzoha
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetic Nanoparticle ◽  
Great Promise ◽  
Nanometer Scale ◽  
Nanoparticle Arrays ◽  
Low Aspect Ratio ◽  
Ordered Arrays ◽  
High Uniformity ◽  
Pulse Reverse ◽  
Hexagonally Ordered

AbstractWe report nanometer-scale ordered arrays of cylindrical magnetic nanoparticles with low aspect ratio and ultra-high uniformity. Protracted anodization provides hexagonally ordered nanopores in amorphous Al2O3. For instance, pulsed electrochemical deposition grows Co particles of uniform length from the bottoms of these pores: these particles are polycrystalline and randomly oriented. The magnetism of the array is dominated by particle shape and by inter-particle magnetostatic interactions. A very clear transition of the anisotropy from perpendicular to in-plane is observed at a height to radius ratio of about 2. This pulse-reverse electrodeposition shows great promise for a reliable synthesis of uniform nanostructures of many metals.

Smart chiral magnetic nanoparticles for highly efficient enantioseparation of tryptophan enantiomers

2018 ◽  
Vol 54 (4) ◽  
pp. 2960-2974 ◽  
Author(s):  
Han-Yan Zhu ◽  
Xiao-Dong Song ◽  
Xiao-Rong Yang ◽  
Chang-Jing Cheng ◽  
Hai-Rong Yu ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Highly Efficient ◽  
Tryptophan Enantiomers
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