Serum SELDI-TOF MS analysis model applied to benign and malignant ovarian tumor identification

2016 ◽  
Vol 8 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Yankun Li ◽  
Xiangchao Zeng
Keyword(s):  
Ovarian Tumor ◽  
Analysis Model ◽  
Pattern Recognition Technique ◽  
Serum Peptide ◽  
Tumor Identification ◽  
Benign Ovarian Tumor ◽  
Malignant Ovarian Tumor ◽  
Peptide Profiles ◽  
Recognition Technique ◽  
Tof Ms

SELDI-TOF MS serum peptide profiles of malignant and benign ovarian tumor samples were studied using a pattern recognition technique.

scholarly journals Expression levels of matrix metalloproteinases in ascites of patients with ovarian cancer and the relationship with pathological characteristics of ovarian cancer

2019 ◽  
Vol 6 (2) ◽  
pp. 12
Author(s):  
Shuna S ◽  
Ping L ◽  
Junfei W
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Expression Levels ◽  
Benign Ovarian Tumor ◽  
Significant Difference ◽  
Malignant Ovarian Tumor ◽  
Serum Ca125 ◽  
The Difference

Objective: To explore the expression levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in ascites in ovarian tumor and provide a theoretical basis for the diagnosis and prognosis evaluation of ovarian cancer ascites.Methods: ELISA was used to detect the levels of MMP-2 and MMP-9 in ascites samples from 73 cases of patients with malignant ovarian tumor, and RIA was used to detect the expression level of CA125 in the serum in these patients.Results: The expression levels of MMP-2 and MMP-9 in ascites in malignant ovarian tumor were higher than those in ascites in benign ovarian tumor (t = 8.08, 10.39, p < .01), and the difference was of statistical significance. The expression levels of MMP-2 and MMP-9 in patients with stage III and IV malignant ovarian tumors were higher than those in patients with stage I and II malignant ovarian tumors, and the difference was statistically significant (t = 2.75, 2.75, p < .05). There was no statistically significant difference in the expression levels of MMP-2 and MMP-9 among the patients with different pathological types, different histological grades, lymph node metastasis or not, different ascites volumes and different residual lesions (p > .05). The sensitivities of detecting MMP-2 and MMP-9 in ascites were 76.0% and 88.0%, respectively, which were significantly higher than those of ascites cytological examinations (χ2 = 4.61, 12.74, p < .05), but in comparison with serum CA125, there was no statistically significant difference (p > .05). The specificities of detecting MMP-2 and MMP-9 in ascites were 78.3% and 82.6%, respectively, which were significantly lower than those of ascites cytological examinations (χ2 = 5.61, 4.38, p < .05), but in comparison with serum CA125, there was no statistically significant difference (χ2 = 1.64, 2.68, p < .05).Conclusions: The levels of MMP-2 and MMP-9 in ascites may be markers for the differential diagnosis of benign and malignant ovarian lesions, and they are related to the prognosis in patients with malignant ovarian tumors.

Research on Serum Spectrum Analysis Model Applied to Pathema Identification

2013 ◽  
Vol 864-867 ◽  
pp. 486-489
Author(s):  
Yan Kun Li ◽  
Shuo Yang
Keyword(s):  
Principal Component ◽  
Classification Model ◽  
Analysis Model ◽  
Recognition Method ◽  
Serum Samples ◽  
Serum Peptide ◽  
Pca Method ◽  
Consensus Classification ◽  
Peptide Profiles ◽  
Practicable Method

The SELDI-TOF MS serum peptide profiles of normal and malignant tumor samples were studied by pattern recognition method. In this study, Partial Least Squares-Discriminate Analysis (PLS-DA) combined with consensus classification model was constructed to predict practical serum samples and compared with the results of principal component analysis (PCA) method. The correctness of consensus PLS-DA classification model for normal and malignant samples was 90% and 84% respectively. So the approach proposed was proved to be a reliable and practicable method for cancer identification.

TUMOR GANAS OVARIUM RESIDIF METASTASIS KARSINOMA MUSIN KE UMBILIKUS, PERITONEUM, DAN CAIRAN ASITES TANPA DITEMUKAN TANDA KEGANASAN PADA PEMERIKSAAN HISTOPATOLOGIS PASCA OPERATIF SEBELUMNYA

2019 ◽  
Vol 3 (2) ◽  
pp. 130-136
Author(s):  
Arif Fadillah ◽  
Andi Friadi
Keyword(s):  
Ovarian Carcinoma ◽  
Ovarian Tumor ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Ovarian Tumors ◽  
Postoperative Chemotherapy ◽  
Definitive Treatment ◽  
Malignant Ovarian Tumor ◽  
Patient Will ◽  
Optimal Debulking

Background : Malignant ovarian tumor are still the number one cause of death and the second most  of incidents for gynecological malignant tumors. The principles of management of ovarian cancer are the same as the principles of handling other malignant diseases, for the treatment of primary lesions operatively and the handling of potential sites of tumor metastases with chemotherapy. Histopathological examination is still considered a gold standard for diagnosis and definitive treatment of malignant ovarian tumors. If histopathologic results are obtained, then the patient will be planned to undergo postoperative chemotherapy. The mismatch between the preoperative and intraoperative clinical features, and the results of postoperative histopathological examination is a problem in managing cases of ovarian malignant tumors.Objective : Report a case of residive ovarian carcinoma with no appearance of malignancy marker in the previous postoperative histopathological examination.Method : Case reportCase : We report the case of a 45-year-old woman with a history of two previous laparotomy. The first operation was carried out in February 2014 on the indication of an extra ovarian cyst, resulting in the impression of a "Follicular Cysts" based on histopathological examination. The second operation was performed in March 2015, performed surgical staging tumors with an indication of malignant ovarian tumors with clinical metastases, but from histopathological examination it was found that "Cystadenoma Ovarii Muscinosum Multiloculare" and "no visible signs of malignancy", so the patient was not managed with postoperative chemotherapy. In April 2019 patients came with complaints of new mass growth, from CT-Scan and USG investigations there was a suspicious impression of a residive ovarian tumor with metastases into the omentum and massive ascites. On May 16, 2019 an optimal debulking was performed with the findings of residive mass, ascites, and mass metastases in the intra operative peritoneum. From the results of histopathological examination, it was found that "Muscinous Carcinoma with metastases to the umbilicus, peritoneum, and ascitic fluidKeywords: Malignant residive ovarian tumor, mucinous ovarian carcinoma

A Variant Group Assignment Three Dimensional Model Using Pattern Recognition Technique

2019 ◽  
Vol 10 (6) ◽  
pp. 1382-1394
Author(s):  
R. Vijayalakshmi ◽  
V. K. Soma Sekhar Srinivas ◽  
E. Manjoolatha ◽  
G. Rajeswari ◽  
M. Sundaramurthy
Keyword(s):  
Pattern Recognition ◽  
Three Dimensional ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Pattern Recognition Technique ◽  
Group Assignment ◽  
Recognition Technique

scholarly journals Almost vanishing polynomials and an application to the Hough transform

2014 ◽  
Vol 13 (08) ◽  
pp. 1450057 ◽  
Author(s):  
Maria-Laura Torrente ◽  
Mauro C. Beltrametti
Keyword(s):  
Hough Transform ◽  
Affine Space ◽  
Bounded Region ◽  
Pattern Recognition Technique ◽  
Local Study ◽  
Affine Hypersurface ◽  
Automated Recognition ◽  
Real Affine ◽  
Necessary And Sufficient ◽  
Recognition Technique

We consider the problem of deciding whether or not an affine hypersurface of equation f = 0, where f = f(x1, …, xn) is a polynomial in ℝ[x1, …, xn], crosses a bounded region 𝒯 of the real affine space 𝔸n. We perform a local study of the problem, and provide both necessary and sufficient numerical conditions to answer the question. Our conditions are based on the evaluation of f at a point p ∈ 𝒯, and derive from the analysis of the differential geometric properties of the hypersurface z = f(x1, …, xn) at p. We discuss an application of our results in the context of the Hough transform, a pattern recognition technique for the automated recognition of curves in images.

scholarly journals Meigs' syndrome with elevated CA 125: case report

2003 ◽  
Vol 121 (5) ◽  
pp. 210-212 ◽  
Author(s):  
Sabas Carlos Vieira ◽  
Leonardo Halley Carvalho Pimentel ◽  
José Carlos Castelo Branco Ribeiro ◽  
Argemiro Ferreira de Andrade Neto ◽  
Jerúsia Oliveira Ibiapina de Santana
Keyword(s):  
Case Report ◽  
Pleural Effusion ◽  
Ovarian Tumor ◽  
Frozen Section ◽  
Transvaginal Ultrasound ◽  
Elevated Serum ◽  
Ca 125 ◽  
Brazilian Woman ◽  
Thoracic Drainage ◽  
Benign Ovarian Tumor

CONTEXT: Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs' syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs' syndrome with elevated CA 125 level. OBJECTIVE: This is a case report of Meigs' syndrome with elevated CA 125 level. CASE REPORT: A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation.

Positive correlation between inhibitors of matrix metalloproteinase 1 and matrix metalloproteinases in malignant ovarian tumor tissues

1997 ◽  
Vol 120 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Fumitaka Kikkawa ◽  
Koji Tamakoshi ◽  
Akihiro Nawa ◽  
Kiyosumi Shibata ◽  
Sadako Yamagata ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Ovarian Tumor ◽  
Positive Correlation ◽  
Matrix Metalloproteinase 1 ◽  
Tumor Tissues ◽  
Malignant Ovarian Tumor
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