Facile preparation of paper substrates coated with different materials and their applications in paper spray mass spectrometry

2015 ◽  
Vol 7 (13) ◽  
pp. 5381-5386 ◽  
Author(s):  
Yajun Zheng ◽  
Xiaoling Zhang ◽  
Haijun Yang ◽  
Xiaoning Liu ◽  
Xinrong Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Filter Paper ◽  
Paper Spray ◽  
Vacuum Filtration ◽  
Facile Preparation ◽  
Paper Substrates

A versatile strategy based on vacuum filtration is introduced for coating different well-defined materials on the surface of filter paper.

2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3866-3873 ◽  
Author(s):  
Deidre E. Damon ◽  
Yosef S. Maher ◽  
Mengzhen Yin ◽  
Fred P. M. Jjunju ◽  
Iain S. Young ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Organic Compounds ◽  
Microfluidic Channels ◽  
Paper Spray ◽  
Paper Spray Ionization ◽  
Ms Analysis ◽  
Wax Printing ◽  
Paper Substrates

Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds.

Metal–organic framework coated paper substrates for paper spray mass spectrometry

2016 ◽  
Vol 8 (45) ◽  
pp. 8004-8014 ◽  
Author(s):  
Xiaoting Wang ◽  
Yajun Zheng ◽  
Teng Wang ◽  
Xingchuang Xiong ◽  
Xiang Fang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metal Organic Framework ◽  
Coated Paper ◽  
Paper Spray ◽  
Metal Organic ◽  
Paper Substrates ◽  
Organic Framework

A comparative study of microporous polyolefin silica-based paper and cellulose paper substrates utilizing paper spray-mass spectrometry in drug analysis

2019 ◽  
Vol 11 (24) ◽  
pp. 3066-3072 ◽  
Author(s):  
Imesha W. De Silva ◽  
Darren T. Converse ◽  
Lauren A. Juel ◽  
Guido F. Verbeck
Keyword(s):  
Mass Spectrometry ◽  
Comparative Study ◽  
Drug Analysis ◽  
Efficient Technique ◽  
Fast Analysis ◽  
Paper Spray ◽  
Cellulose Paper ◽  
Synthetic Substrate ◽  
Paper Substrates

This comparative study proposes an efficient technique by employing a synthetic substrate, which is commercially available, for direct, sensitive, efficient and fast analysis in Paper Spray Mass Spectrometry (PS-MS).

Rapid Diagnosis of Parkinson’s Disease from Sebum using Paper Spray Ionisation Ion Mobility Mass Spectrometry

2020 ◽  
Author(s):  
Depanjan Sarkar ◽  
Drupad Trivedi ◽  
Eleanor Sinclair ◽  
Sze Hway Lim ◽  
Caitlin Walton-Doyle ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ion Mobility ◽  
Neurodegenerative Disorder ◽  
Treatment Options ◽  
Ion Mobility Mass Spectrometry ◽  
Paper Spray ◽  
Molecular Features ◽  
Validation Set

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which identification of robust biomarkers to complement clinical PD diagnosis would accelerate treatment options and help to stratify disease progression. Here we demonstrate the use of paper spray ionisation coupled with ion mobility mass spectrometry (PSI IM-MS) to determine diagnostic molecular features of PD in sebum. PSI IM-MS was performed directly from skin swabs, collected from 34 people with PD and 30 matched control subjects as a training set and a further 91 samples from 5 different collection sites as a validation set. PSI IM-MS elucidates ~ 4200 features from each individual and we report two classes of lipids (namely phosphatidylcholine and cardiolipin) that differ significantly in the sebum of people with PD. Putative metabolite annotations are obtained using tandem mass spectrometry experiments combined with accurate mass measurements. Sample preparation and PSI IM-MS analysis and diagnosis can be performed ~5 minutes per sample offering a new route to for rapid and inexpensive confirmatory diagnosis of this disease.

scholarly journals Rapid Distinction and Semiquantitative Analysis of THC and CBD by Silver-Impregnated Paper Spray Mass Spectrometry

2021 ◽  
Author(s):  
Si Huang ◽  
Frank W. Claassen ◽  
Teris A. van Beek ◽  
Bo Chen ◽  
Jianguo Zeng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Semiquantitative Analysis ◽  
Paper Spray

High-throughput determination of flavanone-O-glycosides in citrus beverages by paper spray tandem mass spectrometry

2021 ◽  
pp. 130060
Author(s):  
Fabio Mazzotti ◽  
Lucia Bartella ◽  
Ines Rosita Talarico ◽  
Anna Napoli ◽  
Leonardo Di Donna
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
High Throughput ◽  
Tandem Mass ◽  
Paper Spray

scholarly journals Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometry

2020 ◽  
Vol 58 (5) ◽  
pp. 836-846 ◽  
Author(s):  
Christine L. Skaggs ◽  
Greta J. Ren ◽  
El Taher M. Elgierari ◽  
Lillian R. Sturmer ◽  
Run Z. Shi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Therapeutic Drug ◽  
Reference Laboratory ◽  
Triple Quadrupole Mass Spectrometer ◽  
Limit Of Quantification ◽  
Paper Spray ◽  
Calibration Curves ◽  
Drug Concentrations ◽  
Limit Of Quantitation ◽  
Anti Fungal

AbstractBackgroundInvasive fungal disease is a life-threatening condition that can be challenging to treat due to pathogen resistance, drug toxicity, and therapeutic failure secondary to suboptimal drug concentrations. Frequent therapeutic drug monitoring (TDM) is required for some anti-fungal agents to overcome these issues. Unfortunately, TDM at the institutional level is difficult, and samples are often sent to a commercial reference laboratory for analysis. To address this gap, the first paper spray-mass spectrometry assay for the simultaneous quantitation of five triazoles was developed.MethodsCalibration curves for fluconazole, posaconazole, itraconazole, hydroxyitraconazole, and voriconazole were created utilizing plasma-based calibrants and four stable isotopic internal standards. No sample preparation was needed. Plasma samples were spotted on a paper substrate in pre-manufactured plastic cartridges, and the dried plasma spots were analyzed directly utilizing paper spray-mass spectrometry (paper spray MS/MS). All experiments were performed on a Thermo Scientific TSQ Vantage triple quadrupole mass spectrometer.ResultsThe calibration curves for the five anti-fungal agents showed good linearity (R2 = 0.98–1.00). The measured assay ranges (lower limit of quantification [LLOQ]–upper limit of quantitation [ULOQ]) for fluconazole, posaconazole, itraconazole, hydroxyitraconazole, and voriconazole were 0.5–50 μg/mL, 0.1–10 μg/mL, 0.1–10 μg/mL, 0.1–10 μg/mL, and 0.1–10 μg/mL, respectively. The inter- and intra-day accuracy and precision were less than 25% over the respective ranges.ConclusionsWe developed the first rapid paper spray-MS/MS assay for simultaneous quantitation of five triazole anti-fungal agents in plasma. The method may be a powerful tool for near-point-of-care TDM aimed at improving patient care by reducing the turnaround time and for use in clinical research.

scholarly journals Paper spray mass spectrometry – A potential complementary technique for the detection of polar compounds in sports drug testing

2020 ◽  
Vol 12 (11-12) ◽  
pp. 1658-1665 ◽  
Author(s):  
Christian Görgens ◽  
Katherine Walker ◽  
Cornelia Boeser ◽  
Neloni Wijeratne ◽  
Claudia Martins ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Drug Testing ◽  
Polar Compounds ◽  
Paper Spray ◽  
Complementary Technique ◽  
Sports Drug Testing

High throughput paper spray mass spectrometry analysis

2013 ◽  
Vol 420 ◽  
pp. 28-33 ◽  
Author(s):  
Luhou Shen ◽  
Johnny Zhang ◽  
Qian Yang ◽  
Nicholas E. Manicke ◽  
Zheng Ouyang
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Mass Spectrometry Analysis ◽  
Paper Spray ◽  
Spectrometry Analysis
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