Triplex DNA logic gate based upon switching on/off their structure by Ag+/cysteine

The Analyst ◽  
2015 ◽  
Vol 140 (21) ◽  
pp. 7322-7326 ◽  
Author(s):  
Zhiyou Xiao ◽  
Houya Zhu ◽  
Aiping Xin ◽  
Yubin Li ◽  
Liansheng Ling
Keyword(s):  
Logic Gate ◽  
Triplex Dna ◽  
Modified Oligonucleotides

Based upon switching on/off the structure of triplex DNA by Ag+/cysteine, a triplex DNA logic gate was constructed using TAMRA/BHQ-2-modified oligonucleotides.

Molecular beacon-based NAND logic gate for sensing triplex DNA binders

RSC Advances ◽  
2014 ◽  
Vol 4 (72) ◽  
pp. 38389-38392 ◽  
Author(s):  
Kai-Cheng Lin ◽  
Chia-Yin Kuo ◽  
Chih-Chun Nieh ◽  
Wei-Lung Tseng
Keyword(s):  
Molecular Beacon ◽  
Logic Gate ◽  
Triplex Dna ◽  
Dna Binders

Molecular beacon-based NAND logic gate was simple, rapid, selective, and sensitive for probing triplex DNA binders.

Heat Diffusion in an Optical Logic Gate Array on Silicon-on-Sapphire

1997 ◽  
Vol 7 (3) ◽  
pp. 739-748
Author(s):  
H. Gualous ◽  
A. Koster ◽  
D. Pascal ◽  
S. Laval
Keyword(s):  
Logic Gate ◽  
Heat Diffusion ◽  
Optical Logic ◽  
Optical Logic Gate ◽  
Gate Array

Rapid Single-Flux-Quantum NOR Logic Gate Realized through the Use of Toggle Storage Loop

2020 ◽  
Vol E103.C (10) ◽  
pp. 547-549
Author(s):  
Yoshinao MIZUGAKI ◽  
Koki YAMAZAKI ◽  
Hiroshi SHIMADA
Keyword(s):  
Logic Gate ◽  
Flux Quantum ◽  
Rapid Single Flux Quantum ◽  
Nor Logic Gate

A Molecular Logic Gate Enables Super-Resolved Imaging of Intracellular Lipid Droplets

2019 ◽  
Author(s):  
Adam Eördögh ◽  
Carolina Paganini ◽  
Dorothea Pinotsi ◽  
Paolo Arosio ◽  
Pablo Rivera-Fuentes
Keyword(s):  
Single Molecule ◽  
Lipid Droplets ◽  
Neutral Lipids ◽  
Logic Gate ◽  
Living Cells ◽  
Three Dimensions ◽  
Single Molecule Imaging ◽  
Molecular Logic Gate ◽  
Molecular Logic ◽  
Cellular Compartments

<div>Photoactivatable dyes enable single-molecule imaging in biology. Despite progress in the development of new fluorophores and labeling strategies, many cellular compartments remain difficult to image beyond the limit of diffraction in living cells. For example, lipid droplets, which are organelles that contain mostly neutral lipids, have eluded single-molecule imaging. To visualize these challenging subcellular targets, it is necessary to develop new fluorescent molecular devices beyond simple on/off switches. Here, we report a fluorogenic molecular logic gate that can be used to image single molecules associated with lipid droplets with excellent specificity. This probe requires the subsequent action of light, a lipophilic environment and a competent nucleophile to produce a fluorescent product. The combination of these requirements results in a probe that can be used to image the boundary of lipid droplets in three dimensions with resolutions beyond the limit of diffraction. Moreover, this probe enables single-molecule tracking of lipids within and between droplets in living cells.</div>

Click conjugation of 4'-C-modified oligonucleotides

2011 ◽  
Author(s):  
Anu Kiviniemi ◽  
Pasi Virta ◽  
Harri Lönnberg
Keyword(s):  
Modified Oligonucleotides

An optical DNA logic gate based on strand displacement and magnetic separation, with response to multiple microRNAs in cancer cell lysates

2017 ◽  
Vol 184 (8) ◽  
pp. 2505-2513 ◽  
Author(s):  
Xiaoting Ji ◽  
Haoyuan Lv ◽  
Minghui Ma ◽  
Binglin Lv ◽  
Caifeng Ding
Keyword(s):  
Magnetic Separation ◽  
Cancer Cell ◽  
Logic Gate ◽  
Strand Displacement ◽  
Cell Lysates

scholarly journals Triazole-Modified Nucleic Acids for the Application in Bioorganic and Medicinal Chemistry

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 628
Author(s):  
Dagmara Baraniak ◽  
Jerzy Boryski
Keyword(s):  
Nucleic Acids ◽  
State Of The Art ◽  
Modified Oligonucleotides ◽  
Synthetic Genes ◽  
Chemically Modified ◽  
Amide Linkage ◽  
Dna And Rna ◽  
Modified Dna ◽  
Modified Nucleic Acids ◽  
Non Coding Rnas

This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties. For example, it does not occur in nature, constitutes an additional pharmacophore with attractive properties being resistant to hydrolysis and other reactions at physiological pH, exhibits biological activity (i.e., antibacterial, antitumor, and antiviral), and can be considered as a rigid mimetic of amide linkage. Herein, it is presented a whole area of useful artificial compounds, from the clickable monomers and dimers to modified oligonucleotides, in the field of nucleic acids sciences. Such modifications of internucleotide linkages are designed to increase the hybridization binding affinity toward native DNA or RNA, to enhance resistance to nucleases, and to improve ability to penetrate cell membranes. The insertion of an artificial backbone is used for understanding effects of chemically modified oligonucleotides, and their potential usefulness in therapeutic applications. We describe the state-of-the-art knowledge on their implications for synthetic genes and other large modified DNA and RNA constructs including non-coding RNAs.

Photonic crystal based on mott phase change material as all-optical bandgap switch and composite logic gate

2021 ◽  
Vol 113 ◽  
pp. 110855
Author(s):  
Lei Zhang ◽  
Yuanhe Sun ◽  
Zhenjiang Li ◽  
Lin Wang ◽  
Shuqi Cao ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Phase Change ◽  
Phase Change Material ◽  
Logic Gate ◽  
Optical Bandgap ◽  
All Optical ◽  
Mott Phase ◽  
Change Material
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