Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth

2015 ◽  
Vol 3 (3) ◽  
pp. 408-416 ◽  
Author(s):  
Ju Yeon Choi ◽  
Thiruganesh Ramasamy ◽  
Tuan Hiep Tran ◽  
Sae Kwang Ku ◽  
Beom Soo Shin ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Systemic Delivery ◽  
Hypoxic Tumor ◽  
Liposomal Nanoparticles

Hybrid liposomal nanoparticles for systemic delivery of axitinib inhibit hypoxic tumor growth.

scholarly journals WITHDRAWN: Modified delivery of axitinib loaded nanohybrid liposomal nanoparticles for hypoxic tumor growth

2015 ◽  
Author(s):  
Ju Yeon Choi ◽  
Ramasamya Thiruganesh ◽  
Tran Tuan Hiep ◽  
Raj Kumar Thapa ◽  
Dong Shik Kim ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Hypoxic Tumor ◽  
Liposomal Nanoparticles

Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice

2006 ◽  
Vol 114 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Won Jong Kim ◽  
James W. Yockman ◽  
Ji Hoon Jeong ◽  
Lane V. Christensen ◽  
Minhyung Lee ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Systemic Delivery ◽  
Tumor Bearing ◽  
Inhibition Of Tumor Growth

scholarly journals Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment

2021 ◽  
Vol 12 ◽  
Author(s):  
Zicong He ◽  
Shuixing Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Tumor Associated Macrophages ◽  
Mediate Immune Response ◽  
Functional Transformation ◽  
Functional Differences ◽  
Inflammatory Phenotype ◽  
Internal Mechanism ◽  
Hypoxic Tumor ◽  
Early Phases

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of their functional differences in tumor growth, TAMs are usually categorized into two subsets of M1 and M2. It is well established that the tumor microenvironment (TME) is characterized by hypoxia along with tumor progression. TAMs adopt an M1-like pro-inflammatory phenotype at the early phases of oncogenesis and mediate immune response that inhibits tumor growth. As tumors progress, anabatic hypoxia of the TME gradually induces the M2-like functional transformation of TAMs by means of direct effects, metabolic influence, lactic acidosis, angiogenesis, remodeled stroma, and then urges them to participate in immunosuppression, angiogenesis and other tumor-supporting procedure. Therefore, thorough comprehension of internal mechanism of this TAM functional transformation in the hypoxic TME is of the essence, and might provide some novel insights in hypoxic tumor immunotherapeutic strategies.

Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth

2012 ◽  
Vol 9 (10) ◽  
pp. 2863-2874 ◽  
Author(s):  
Xi-Qiu Liu ◽  
Meng-Hua Xiong ◽  
Xiao-Ting Shu ◽  
Rui-Zhi Tang ◽  
Jun Wang
Keyword(s):  
Tumor Growth ◽  
Therapeutic Delivery ◽  
Hypoxic Tumor ◽  
Sirna Silencing ◽  
Micellar Nanoparticles

scholarly journals Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer

2013 ◽  
pp. 4481 ◽  
Author(s):  
Najmunnisa Nasreen ◽  
Hung-yen Lee ◽  
Kamal Mohammed ◽  
Frederic Kaye ◽  
Parvesh Sharma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Growth ◽  
Targeted Delivery ◽  
Inhibit Tumor Growth ◽  
Liposomal Nanoparticles

scholarly journals Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth

2012 ◽  
Vol 159 (3) ◽  
pp. 384-392 ◽  
Author(s):  
Mohammad Aminur Rahman ◽  
A.R.M. Ruhul Amin ◽  
Xu Wang ◽  
Jonathan E. Zuckerman ◽  
Chung Hang J. Choi ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Head And Neck ◽  
Head And Neck Tumor ◽  
Systemic Delivery ◽  
Neck Tumor

Suppression of tumor growth by systemic delivery of anti-VEGF siRNA with cell-penetrating peptide-modified MPEG–PCL nanomicelles

2012 ◽  
Vol 81 (3) ◽  
pp. 470-477 ◽  
Author(s):  
Takanori Kanazawa ◽  
Ken Sugawara ◽  
Ko Tanaka ◽  
Shogo Horiuchi ◽  
Yuuki Takashima ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Penetrating Peptide ◽  
Systemic Delivery ◽  
Anti Vegf ◽  
Cell Penetrating
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