scholarly journals Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth

2009 ◽  
Vol 16 (8) ◽  
pp. 655-663 ◽  
Author(s):  
B Hu ◽  
L Kou ◽  
C Li ◽  
L-P Zhu ◽  
Y-R Fan ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Delivery System ◽  
Bifidobacterium Longum ◽  
Chemotherapeutic Drugs ◽  
Hypoxic Tumor

scholarly journals Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors

2000 ◽  
Vol 7 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Kazuyuki Yazawa ◽  
Minoru Fujimori ◽  
Jun Amano ◽  
Yasunobu Kano ◽  
Shun'ichiro Taniguchi
Keyword(s):  
Gene Therapy ◽  
Delivery System ◽  
Bifidobacterium Longum ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Selective Localization

scholarly journals Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment

2021 ◽  
Vol 12 ◽  
Author(s):  
Zicong He ◽  
Shuixing Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Tumor Associated Macrophages ◽  
Mediate Immune Response ◽  
Functional Transformation ◽  
Functional Differences ◽  
Inflammatory Phenotype ◽  
Internal Mechanism ◽  
Hypoxic Tumor ◽  
Early Phases

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of their functional differences in tumor growth, TAMs are usually categorized into two subsets of M1 and M2. It is well established that the tumor microenvironment (TME) is characterized by hypoxia along with tumor progression. TAMs adopt an M1-like pro-inflammatory phenotype at the early phases of oncogenesis and mediate immune response that inhibits tumor growth. As tumors progress, anabatic hypoxia of the TME gradually induces the M2-like functional transformation of TAMs by means of direct effects, metabolic influence, lactic acidosis, angiogenesis, remodeled stroma, and then urges them to participate in immunosuppression, angiogenesis and other tumor-supporting procedure. Therefore, thorough comprehension of internal mechanism of this TAM functional transformation in the hypoxic TME is of the essence, and might provide some novel insights in hypoxic tumor immunotherapeutic strategies.

scholarly journals A new expression plasmid in Bifidobacterium longum as a delivery system of endostatin for cancer gene therapy

2006 ◽  
Vol 14 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Y-F Xu ◽  
L-P Zhu ◽  
B Hu ◽  
G-F Fu ◽  
H-Y Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Delivery System ◽  
Bifidobacterium Longum ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Expression Plasmid

Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth

2012 ◽  
Vol 9 (10) ◽  
pp. 2863-2874 ◽  
Author(s):  
Xi-Qiu Liu ◽  
Meng-Hua Xiong ◽  
Xiao-Ting Shu ◽  
Rui-Zhi Tang ◽  
Jun Wang
Keyword(s):  
Tumor Growth ◽  
Therapeutic Delivery ◽  
Hypoxic Tumor ◽  
Sirna Silencing ◽  
Micellar Nanoparticles

scholarly journals Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Taylor Smith ◽  
Kevin Affram ◽  
Ebony L. Nottingham ◽  
Bo Han ◽  
Felix Amissah ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Delivery System ◽  
Therapeutic Efficacy ◽  
Confocal Imaging ◽  
Time Curve ◽  
Solid Lipid ◽  
Cytotoxicity Studies ◽  
Hct 116 ◽  
Efficacy Studies

Abstract 5-Fluorouracil (5-FU) is a standard treatment option for colorectal cancer (CRC) but its rapid metabolism and systemic instability (short half-life) has hindered its therapeutic efficacy. The objective of this study was to develop a novel drug delivery system, solid lipid nanoparticle (SLN), capable of delivering high payload of 5-FU to treat CRC. The rational was to improve 5FU-nanocarrier compatibility and therapeutic efficacy. The SLN-loaded 5-FU was developed by utilizing a Strategic and unique Method to Advance and Refine the Treatment (SMART) of CRC through hot and cold homogenization approach. The SLN was made of unique PEGylated lipids and combination of the surfactants. Cytotoxicity studies, clonogenic assay, flow cytometry and confocal imaging were conducted to evaluate the effectiveness and cellular uptake of 5FU-SLN4 in HCT-116 cancer cells. Pharmacokinetic (PK) parameters and receptor expressions were determined while tumor efficacy studies were conducted on mouse bearing subcutaneous HCT-116 cancer. Among the all the formulations, 5FU-SLN4 was the most effective with particle size of was 263 ± 3 nm, zeta potential was 0.1 ± 0.02 and entrapment efficiency of 81 ± 10%. The IC50 value of 5FU-SLN4 (7.4 ± 0.02 µM) was 2.3 fold low compared with 5-FU (17.7 ± 0.03 µM). For tumor efficacy studies, 5FU-SLN4 significantly inhibited tumor growth in comparison to 5-FU while area-under plasma concentration-time curve (AUC) of 5FU-SLN4 was 3.6 fold high compared with 5-FU. HER2 receptors expression were markedly reduced in 5-FU-SLN4 treated mice compared with 5FU and liver and kidney tissues showed no toxicity at dose of 20 mg/kg. 5FU-SLN4 was highly cytotoxic against HCT-116 cells and significantly inhibited subcutaneous tumor growth in mice compared with 5-FU. This emphasizes the significance of developing a smart nano-delivery system to optimize the delivery efficiency of anticancer drugs to tumors.

scholarly journals A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Jonathan Rios-Doria ◽  
Adam Carie ◽  
Tara Costich ◽  
Brian Burke ◽  
Habib Skaff ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biological Fluids ◽  
Drug Carriers ◽  
Chemotherapeutic Drugs ◽  
Polymer Micelle ◽  
Drug Stabilization

Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers offer a promising approach for formulating and achieving improved delivery of hydrophobic chemotherapeutic drugs; however, conventional micelles do not have long-term stability in complex biological environments such as plasma. To address this problem, a novel triblock copolymer has been developed to encapsulate several different hydrophobic drugs into stable polymer micelles. These micelles have been engineered to be stable at low concentrations even in complex biological fluids, and to release cargo in response to low pH environments, such as in the tumor microenvironment or in tumor cell endosomes. The particle sizes of drugs encapsulated ranged between 30–80 nm, with no relationship to the hydrophobicity of the drug. Stabilization of the micelles below the critical micelle concentration was demonstrated using a pH-reversible crosslinking mechanism, with proof-of-concept demonstrated in both in vitro and in vivo models. Described herein is polymer micelle drug delivery system that enables encapsulation and stabilization of a wide variety of chemotherapeutic drugs in a single platform.

scholarly journals Chemo-enzymatic Synthesis of Ester-Linked Docetaxel-Glycoside Conjugate and its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab and Cetuximab

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985880
Author(s):  
Yuya Fujitaka ◽  
Hiroki Hamada ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka ◽  
Kei Shimoda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Effective Suppression ◽  
Anti Cancer ◽  
Cancer Activity

Synthesis of ester-linked glucoside conjugate of docetaxel, 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, was carried out by chemo-enzymatic procedures. The EE and LE values for hybrid-bio-nanocapsules of 7-propionyldocetaxel 3''- O-α-D-glucopyranoside were much improved rather than those of docetaxel. The hybrid-bio-nanocapsules targeted with trastuzumab and cetuximab, which contained 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, showed high in vivo anti-cancer activity, ie, effective suppression of tumor growth, respectively.

Sign in / Sign up

Export Citation Format

Share Document