Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

2015 ◽  
Vol 3 (5) ◽  
pp. 759-765 ◽  
Author(s):  
Mathieu Bibian ◽  
Jeroen Mangelschots ◽  
James Gardiner ◽  
Lynne Waddington ◽  
Maria M. Diaz Acevedo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Rational Design ◽  
Controlled Drug Release ◽  
Peptide Sequence ◽  
Release Drug ◽  
Scale Preparation ◽  
Amphiphilic Peptide

The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for controlled-drug release, which is the smallest tunable ionic self-complementary hydrogelating peptide reported to date making it attractive for larger scale preparation.

scholarly journals Hitchhiking on Controlled-Release Drug Delivery Systems: Opportunities and Challenges for Cancer Vaccines

2021 ◽  
Vol 12 ◽  
Author(s):  
Lu Han ◽  
Ke Peng ◽  
Li-Ying Qiu ◽  
Meng Li ◽  
Jing-Hua Ruan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Immune Responses ◽  
Cancer Vaccines ◽  
Drug Delivery Systems ◽  
Rational Design ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Release Drug ◽  
Multiple Drugs

Cancer vaccines represent among the most promising strategies in the battle against cancers. However, the clinical efficacy of current cancer vaccines is largely limited by the lack of optimized delivery systems to generate strong and persistent antitumor immune responses. Moreover, most cancer vaccines require multiple injections to boost the immune responses, leading to poor patient compliance. Controlled-release drug delivery systems are able to address these issues by presenting drugs in a controlled spatiotemporal manner, which allows co-delivery of multiple drugs, reduction of dosing frequency and avoidance of significant systemic toxicities. In this review, we outline the recent progress in cancer vaccines including subunit vaccines, genetic vaccines, dendritic cell-based vaccines, tumor cell-based vaccines and in situ vaccines. Furthermore, we highlight the efforts and challenges of controlled or sustained release drug delivery systems (e.g., microparticles, scaffolds, injectable gels, and microneedles) in ameliorating the safety, effectiveness and operability of cancer vaccines. Finally, we briefly discuss the correlations of vaccine release kinetics and the immune responses to enlighten the rational design of the next-generation platforms for cancer therapy.

scholarly journals Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules

2010 ◽  
Vol 8 (56) ◽  
pp. 451-456 ◽  
Author(s):  
Ming-Wei Chang ◽  
Eleanor Stride ◽  
Mohan Edirisinghe
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Polymeric Materials ◽  
Controlled Drug Release ◽  
Ambient Conditions ◽  
Smart Polymer ◽  
Release Studies ◽  
Stimulus Responsive ◽  
New Strategy

Drug-delivery systems with a unique capability to respond to a given stimulus can improve therapeutic efficacy. However, development of such systems is currently heavily reliant on responsive polymeric materials and pursuing this singular strategy limits the potential for clinical translation. In this report, with a model system used for drug-release studies, we demonstrate a new strategy: how a temperature-responsive non-toxic, volatile liquid can be encapsulated and stored under ambient conditions and subsequently programmed for controlled drug release without relying on a smart polymer. When the stimulus temperature is reached, controlled encapsulation of different amounts of dye in the capsules is achieved and facilitates subsequent sustained release. With different ratios of the liquid (perfluorohexane): dye in the capsules, enhanced controlled release with real-time response is provided. Hence, our findings offer great potential for drug-delivery applications and provide new generic insights into the development of stimuli drug-release systems.

scholarly journals Ciprofloxacin intercalated in fluorohectorite clay: identical pure drug activity and toxicity with higher adsorption and controlled release rate

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26537-26545 ◽  
Author(s):  
E. C. dos Santos ◽  
Z. Rozynek ◽  
E. L. Hansen ◽  
R. Hartmann-Petersen ◽  
R. N. Klitgaard ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Adsorption Capacity ◽  
Release Rate ◽  
Controlled Drug Release ◽  
Drug Effectiveness ◽  
Pure Drug ◽  
Synthetic Clay ◽  
Very High

We present the use of the synthetic clay fluorohectorite (Fh) as a drug delivery system of the antibiotic ciprofloxacin. The adsorption capacity is very high, and Fh promotes controlled drug release without changing drug effectiveness and toxicity.

Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon

2020 ◽  
Vol 26 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Basic Principle ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Sustained Drug Release ◽  
Mucosal Tissues

: Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of and discuss specific strategies for developing mucoadhesive systems for colon-targeted oral delivery with controlled drug release, including mucoadhesive matrices, cross-linked mucoadhesive microparticles, coatings and mucoadhesive nanoparticles. The understanding of the basic principle of these designs and advanced formulations throughout will lead to the development of products with efficient drug delivery at the colon for therapies for different diseases.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

NIR responsive AuNRs/pNIPAM/PEGDA inverse opal hydrogel microcarriers for controllable drug delivery

2021 ◽  
Author(s):  
Lingzi Liu ◽  
Xiaoyan Sun ◽  
Baofen Ye ◽  
Zhengyu Yan
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Delivery System ◽  
Gold Nanorods ◽  
Controlled Drug Release ◽  
Inverse Opal

Particle-based delivery system has merged as a powerful platform in controlled drug release. The present study developed a new inverse opal hydrogel microcarriers system composed of gold nanorods (AuNRs) for...

A general method to greatly enhance ultrasound-responsiveness for common polymeric assemblies

2020 ◽  
Vol 11 (19) ◽  
pp. 3296-3304
Author(s):  
Jinkang Dou ◽  
Ruiqi Yang ◽  
Kun Du ◽  
Li Jiang ◽  
Xiayun Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Promising Technique ◽  
Polymeric Assemblies ◽  
General Method

Ultrasound-controlled drug release is a very promising technique for controlled drug delivery due to the unique advantages of ultrasound as the stimulus.

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