PEG–poly(amino acid)s-encapsulated tanshinone IIA as potential therapeutics for the treatment of hepatoma

2014 ◽  
Vol 2 (20) ◽  
pp. 3115-3122 ◽  
Author(s):  
Yan Wang ◽  
Frankie Costanza ◽  
Haifan Wu ◽  
Daqian Song ◽  
Jianfeng Cai ◽  
...  
Keyword(s):  
Amino Acid ◽  
Drug Carrier ◽  
Tanshinone Iia ◽  
Novel Drug ◽  
Potential Therapeutics

PEG–poly(amino acid)s are used as a novel drug carrier for the treatment of hepatoma.

Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization

2019 ◽  
Vol 16 (3) ◽  
pp. 258-265
Author(s):  
Kei Takahashi ◽  
Tomomi Masuda ◽  
Mitsunori Harada ◽  
Tadashi Inoue ◽  
Shinsuke Nakamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Choroidal Neovascularization ◽  
Pigment Epithelium ◽  
Drug Carrier ◽  
Retinal Pigment ◽  
Laser Coagulation ◽  
Antiangiogenic Agents ◽  
Drug Carrier System ◽  
Novel Drug ◽  
Drug Delivery Devices

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.

scholarly journals The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 409
Author(s):  
Sarah Geahchan ◽  
Hermann Ehrlich ◽  
M. Azizur Rahman
Keyword(s):  
Viral Entry ◽  
Marine Sponges ◽  
Sulfated Polysaccharides ◽  
Marine Resources ◽  
Active Metabolites ◽  
Marine Metabolites ◽  
Main Protease ◽  
Novel Drug ◽  
First Time ◽  
Potential Therapeutics

The ongoing pandemic has led to an urgent need for novel drug discovery and potential therapeutics for Sars-CoV-2 infected patients. Although Remdesivir and the anti-inflammatory agent dexamethasone are currently on the market for treatment, Remdesivir lacks full efficacy and thus, more drugs are needed. This review was conducted through literature search of PubMed, MDPI, Google Scholar and Scopus. Upon review of existing literature, it is evident that marine organisms harbor numerous active metabolites with anti-viral properties that serve as potential leads for COVID-19 therapy. Inorganic polyphosphates (polyP) naturally found in marine bacteria and sponges have been shown to prevent viral entry, induce the innate immune response, and downregulate human ACE-2. Furthermore, several marine metabolites isolated from diverse sponges and algae have been shown to inhibit main protease (Mpro), a crucial protein required for the viral life cycle. Sulfated polysaccharides have also been shown to have potent anti-viral effects due to their anionic properties and high molecular weight. Likewise, select marine sponges produce bromotyrosines which have been shown to prevent viral entry, replication and protein synthesis. The numerous compounds isolated from marine resources demonstrate significant potential against COVID-19. The present review for the first time highlights marine bioactive compounds, their sources, and their anti-viral mechanisms of action, with a focus on potential COVID-19 treatment.

Lipid Nano-Sphere(LNS), a protein-free analogue of lipoproteins, as a novel drug carrier for parenteral administration. IV

1994 ◽  
Vol 28 (1-3) ◽  
pp. 352-353 ◽  
Author(s):  
J. Seki ◽  
H. Sasaki ◽  
M. Doi ◽  
H. Yoshikawa ◽  
Y. Takahashi ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Parenteral Administration ◽  
Novel Drug

Chitosan Polymer as Novel Drug Carrier

2015 ◽  
pp. 533-556
Author(s):  
Aakanchha Jain ◽  
Sourabh Jain ◽  
Vikas Jain ◽  
Dharmveer Kohli
Keyword(s):  
Drug Carrier ◽  
Novel Drug

scholarly journals Novel Drug Carrier: 5-Fluorouracil Formulation in Nanoporous Biogenic Mg-calcite from Blue Crab Shells—Proof of Concept

ACS Omega ◽  
2021 ◽  
Author(s):  
Geza Lazar ◽  
Fran Nekvapil ◽  
Razvan Hirian ◽  
Branko Glamuzina ◽  
Tudor Tamas ◽  
...  
Keyword(s):  
Blue Crab ◽  
Drug Carrier ◽  
Proof Of Concept ◽  
Novel Drug

scholarly journals The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System

2015 ◽  
Vol 2015 ◽  
pp. 1-27 ◽  
Author(s):  
Karolina Werengowska-Ciećwierz ◽  
Marek Wiśniewski ◽  
Artur P. Terzyk ◽  
Sylwester Furmaniak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Nanoparticles ◽  
Physical Adsorption ◽  
Drug Carrier ◽  
Anticancer Therapy ◽  
Modern Drug ◽  
Polycyclic Groups ◽  
Novel Drug ◽  
Small Elements

Nanomedicine is, generally, the application of nanotechnology to medicine. The term nanomedicine includes monitoring, construction of novel drug delivery systems, and any possible future applications of nanotechnology and nanovaccinology. In this review, the most important ligand-nanocarrier and drug-nanocarrier bioconjugations are described. The detailed characterizations of covalently formed bonds between targeted ligand and nanocarrier, including amide, thioether, disulfide, acetyl-hydrazone and polycyclic groups, are described. Also, the coupling of small elements and heteroatoms in the form of R-X-R the “click chemistry” groups is shown. Physical adsorption and chemical bonding of drug to nanocarrier surface involving drug on the internal or external surfaces of nanocarriers are described throughout possibility of the formation of the above-mentioned functionalities. Moreover, the most popular nanostructures (liposomes, micelles, polymeric nanoparticles, dendrimers, carbon nanotubes, and nanohorns) are characterized as nanocarriers. Building of modern drug carrier is a new method which could be effectively applied in targeted anticancer therapy.

Mesoporous carbon as a novel drug carrier of fenofibrate for enhancement of the dissolution and oral bioavailability

2013 ◽  
Vol 452 (1-2) ◽  
pp. 382-389 ◽  
Author(s):  
Xia Niu ◽  
Long Wan ◽  
Zhong Hou ◽  
Tianyi Wang ◽  
Changshan Sun ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Mesoporous Carbon ◽  
Drug Carrier ◽  
Novel Drug
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