scholarly journals A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

2015 ◽  
Vol 6 (3) ◽  
pp. 2002-2009 ◽  
Author(s):  
Xuanjun Wu ◽  
Bijuan Lin ◽  
Mingzhu Yu ◽  
Liu Yang ◽  
Jiahuai Han ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Liver Tumor ◽  
High Performance ◽  
Tumor Imaging ◽  
Subcutaneous Tumor ◽  
Dual Modality

High-performance illumination of subcutaneous tumor and liver tumor foci was achieved with sialic acid-targeted acid-responsive nanovesicles which become fluorescent and photoacoustic upon internalization into tumor lysosomes.

A fluorescently labelled sialic acid for high performance intraoperative tumor detection

2014 ◽  
Vol 2 (8) ◽  
pp. 1120-1127 ◽  
Author(s):  
Xuanjun Wu ◽  
Yunpeng Tian ◽  
Mingzhu Yu ◽  
Bijuan Lin ◽  
Jiahuai Han ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Liver Tumor ◽  
High Performance ◽  
Tumor Detection ◽  
Cellular Proteins ◽  
Subcutaneous Tumor

High performance illumination of subcutaneous tumor and liver tumor foci in mice was achieved with FITC-labelled sialic acid, which is preferentially taken up into tumors and then incorporated into cellular proteins through an endogenous sialylation pathway.

A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors

2014 ◽  
Vol 2 (7) ◽  
pp. 972-979 ◽  
Author(s):  
Xuanjun Wu ◽  
Yunpeng Tian ◽  
Mingzhu Yu ◽  
Jiahuai Han ◽  
Shoufa Han
Keyword(s):  
Liver Tumor ◽  
High Performance ◽  
Micellar System ◽  
Subcutaneous Tumor ◽  
Signal Activation

High-performance illumination of subcutaneous tumor and liver tumor foci at sub-millimeter levels was achieved with lectin-targeted glyco-micelles which become fluorescent upon internalization into tumor lysosomes.

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

Cyclic-Arginine-Glycine-Aspartic (c-RGD) Conjugated Polymeric Micelles for SPECT/NIRF Dual-Modality Tumor Imaging

2018 ◽  
Vol 18 (11) ◽  
pp. 7858-7866
Author(s):  
Hua Zhu ◽  
Lei Xia ◽  
Xiaoxia Xu ◽  
Fei Liu ◽  
Jun Zhao ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Tumor Imaging ◽  
Dual Modality

Effects of (-)-Menthol on Arylamine N-Acetyltransferase Activity in Human Liver Tumor Cells

2001 ◽  
Vol 29 (02) ◽  
pp. 321-329 ◽  
Author(s):  
Jing-Pin Lin ◽  
Yuh-Ching Li ◽  
Weng-Chuan Lin ◽  
Ching-Liang Hsieh ◽  
Jing-Gung Chung
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Human Liver ◽  
High Performance ◽  
Time Course ◽  
Tumor Cell Line ◽  
Intact Cells ◽  
Steady State Kinetic ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition

To evaluate whether or not (-)-menthol affects arylamine N-acetyltransferase (NAT) activity, we selected human liver tumor cell line (J 5) for examination. By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. (-)-Menthol displayed a dose-dependent inhibition to cytosolic NAT activity. Time-course experiments showed that NAT activity measured from intact human liver tumor cells was inhibited by (-)-menthol for up to 24 hrs. But in human liver tumor intact cells, the low doses (0.0032 and 0.032 mM) of (-)-menthol inhibited NAT activity andthe 0.32 mM (-)-menthol did not show any significant differences between control and (-)-menthol treated groups. Using standard steady-state kinetic analysis, it was demonstrated that (-)-menthol was a possible uncompetitive inhibitor (decrease Km and Vmax) to NAT activity in cytosols. This report is the first demonstration which showed (-)-menthol affect on human liver tumor cells NAT activity.

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