A fluorescently labelled sialic acid for high performance intraoperative tumor detection

2014 ◽  
Vol 2 (8) ◽  
pp. 1120-1127 ◽  
Author(s):  
Xuanjun Wu ◽  
Yunpeng Tian ◽  
Mingzhu Yu ◽  
Bijuan Lin ◽  
Jiahuai Han ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Liver Tumor ◽  
High Performance ◽  
Tumor Detection ◽  
Cellular Proteins ◽  
Subcutaneous Tumor

High performance illumination of subcutaneous tumor and liver tumor foci in mice was achieved with FITC-labelled sialic acid, which is preferentially taken up into tumors and then incorporated into cellular proteins through an endogenous sialylation pathway.

scholarly journals A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

2015 ◽  
Vol 6 (3) ◽  
pp. 2002-2009 ◽  
Author(s):  
Xuanjun Wu ◽  
Bijuan Lin ◽  
Mingzhu Yu ◽  
Liu Yang ◽  
Jiahuai Han ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Liver Tumor ◽  
High Performance ◽  
Tumor Imaging ◽  
Subcutaneous Tumor ◽  
Dual Modality

High-performance illumination of subcutaneous tumor and liver tumor foci was achieved with sialic acid-targeted acid-responsive nanovesicles which become fluorescent and photoacoustic upon internalization into tumor lysosomes.

A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors

2014 ◽  
Vol 2 (7) ◽  
pp. 972-979 ◽  
Author(s):  
Xuanjun Wu ◽  
Yunpeng Tian ◽  
Mingzhu Yu ◽  
Jiahuai Han ◽  
Shoufa Han
Keyword(s):  
Liver Tumor ◽  
High Performance ◽  
Micellar System ◽  
Subcutaneous Tumor ◽  
Signal Activation

High-performance illumination of subcutaneous tumor and liver tumor foci at sub-millimeter levels was achieved with lectin-targeted glyco-micelles which become fluorescent upon internalization into tumor lysosomes.

Preparation and Evaluation of Lyophilized Iopromide-Carrying Liposomes for Liver Tumor Detection

1993 ◽  
Vol 28 (9) ◽  
pp. 838-844 ◽  
Author(s):  
Andreas Sachse ◽  
Jens U. Leike ◽  
Georg L. RÖling ◽  
Susanne E. Wagner ◽  
Werner Krause
Keyword(s):  
Liver Tumor ◽  
Tumor Detection ◽  
Preparation And Evaluation

Pathologic liver tumor detection using feature aligned multi-scale convolutional network

2022 ◽  
pp. 102244
Author(s):  
Tsung-Lung Yang ◽  
Hung-Wen Tsai ◽  
Wei-Che Huang ◽  
Jung-Chia Lin ◽  
Jia-Bin Liao ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Detection ◽  
Convolutional Network ◽  
Multi Scale

Effects of (-)-Menthol on Arylamine N-Acetyltransferase Activity in Human Liver Tumor Cells

2001 ◽  
Vol 29 (02) ◽  
pp. 321-329 ◽  
Author(s):  
Jing-Pin Lin ◽  
Yuh-Ching Li ◽  
Weng-Chuan Lin ◽  
Ching-Liang Hsieh ◽  
Jing-Gung Chung
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Human Liver ◽  
High Performance ◽  
Time Course ◽  
Tumor Cell Line ◽  
Intact Cells ◽  
Steady State Kinetic ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition

To evaluate whether or not (-)-menthol affects arylamine N-acetyltransferase (NAT) activity, we selected human liver tumor cell line (J 5) for examination. By using high performance liquid chromatography, NAT activity for acetylation of 2-aminofluorene (AF) was determined. (-)-Menthol displayed a dose-dependent inhibition to cytosolic NAT activity. Time-course experiments showed that NAT activity measured from intact human liver tumor cells was inhibited by (-)-menthol for up to 24 hrs. But in human liver tumor intact cells, the low doses (0.0032 and 0.032 mM) of (-)-menthol inhibited NAT activity andthe 0.32 mM (-)-menthol did not show any significant differences between control and (-)-menthol treated groups. Using standard steady-state kinetic analysis, it was demonstrated that (-)-menthol was a possible uncompetitive inhibitor (decrease Km and Vmax) to NAT activity in cytosols. This report is the first demonstration which showed (-)-menthol affect on human liver tumor cells NAT activity.

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