scholarly journals Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions

2014 ◽  
Vol 5 (10) ◽  
pp. 4076-4081 ◽  
Author(s):  
RuoWen Wang ◽  
Chunming Wang ◽  
Yang Cao ◽  
Zhi Zhu ◽  
Chaoyong Yang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Hydrophobic Interactions ◽  
Acid Analogue ◽  
Nucleic Acid Analogues

An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented.

Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

2004 ◽  
Vol 126 (46) ◽  
pp. 15006-15007 ◽  
Author(s):  
Rekha Pattanayek ◽  
Latsavongsakda Sethaphong ◽  
Chongle Pan ◽  
Marija Prhavc ◽  
Thazha P. Prakash ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Difference ◽  
Nucleic Acid Analogues

Self-assembly of nanostructures with multiferroic components using nucleic acid linkers

2016 ◽  
Vol 7 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Ferman A. Chavez ◽  
Gopalan Srinivasan
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Image Position

Abstract

Synthesis, Characterization, Investigation of Capacitance and Redox Properties of Self-assembled Phe-Phe with Ferrocene Conjugates

2021 ◽  
Author(s):  
Om Shanker Tiwari
Keyword(s):  
Nucleic Acid ◽  
Electrochemical Properties ◽  
Self Assembly ◽  
Peptide Nucleic Acid ◽  
Redox Properties ◽  
Self Assembled ◽  
Acid Unit

The synthesis, nanostructure self-assembly and electrochemical properties of a series of ferrocene conjugated peptides derived from the dipeptide Phe-Phe, nucleoside and the peptide nucleic acid unit which are covalently attached...

scholarly journals Rules for the self-assembly of ESCRT-III on endosomes

2021 ◽  
Author(s):  
Simon Sprenger ◽  
Simona M. Migliano ◽  
Florian Oleschko ◽  
Marvin Kobald ◽  
Michael Hess ◽  
...  
Keyword(s):  
Self Assembly ◽  
Hydrophobic Interactions ◽  
The Self ◽  
Amino Acid Residues ◽  
Lateral Expansion ◽  
Endosomal Sorting ◽  
Aaa Atpase ◽  
Charged Amino Acids ◽  
Membrane Budding ◽  
Positively Charged

ABSTRACTThe endosomal sorting complexes required for transport (ESCRT) mediate various membrane remodeling processes in cells by mechanism that are incompletely understood. Here we combined genetic experiments in budding yeast with site-specific cross-linking to identify rules that govern the self-assembly of individual ESCRT-III proteins into functional ESCRT-III complexes on endosomes. Together with current structural models of ESCRT-III, our findings suggest that, once nucleated, the growing Snf7 protofilament seeds the lateral co-assembly of a Vps24 - Vps2 heterofilament. Both Vps24 and Vps2 use positively charged amino acid residues in their helices α1 to interact with negatively charged amino acids in helix α4 of Snf7 subunits of the protofilament. In the Vps24 - Vps2 heterofilament, the two subunits alternate and interact with each other using hydrophobic interactions between helices α2/α3. The co-assembly of the Vps24 - Vps2 heterofilament restricts the lateral expansion of Snf7 protofilaments and leads the immediate recruitment of the AAA-ATPase Vps4. This self-assembly process of three ESCRT-III subunits results in the formation of a Snf7 protofilament and the co-assembly of a Vps24 - Vps2 heterofilament. This sets the stage for Vps4 recruitment and the subsequent ATP-driven dynamic self-organization of ESCRT-III / Vps4 assemblies and the ensuing membrane budding and scission events.

ChemInform Abstract: Nucleic Acid Encoding to Program Self-Assembly in Chemical Biology

ChemInform ◽  
2008 ◽  
Vol 39 (41) ◽  
Author(s):  
Zbigniew L. Pianowski ◽  
Nicolas Winssinger
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Chemical Biology

DNA and RNA enzymes with peroxidase activity — An investigation into the mechanism of action

2006 ◽  
Vol 84 (4) ◽  
pp. 613-619 ◽  
Author(s):  
Paola Travascio ◽  
Dipankar Sen ◽  
Andrew J Bennet
Keyword(s):  
Nucleic Acid ◽  
Hydrophobic Interactions ◽  
Basic Component ◽  
Axial Position ◽  
General Base ◽  
Dna And Rna ◽  
Polar Environment ◽  
Guanine Quadruplex ◽  
Acid Catalyzed ◽  
Catalyzed Reactions

A DNA–hemin complex (PS2.M–hemin), and its RNA counterpart (rPS2.M–hemin), have previously been reported, in the presence of nitrogenous buffers such as HEPES, to show enhanced peroxidative activity relative to both uncomplexed hemin and a control DNA–hemin complex (Chem. Biol. 5, 505, 1998). A kinetic analysis of these two hemin-utilizing nucleic acid enzymes provides key insights into the mechanisms for their catalyzed peroxidation reactions. First, control experiments indicate that charge on the added detergent, required for solubility reasons, has little effect on the efficiency of the nucleic-acid-catalyzed reactions. Second, the key functional impact of the two nucleic acid frameworks, either DNA or RNA, appears to be a reduction in the acidity of a water molecule coordinated to the iron atom of the hemin that is bound to the ribozyme and DNAzyme scaffolds. This effect could result from a polar environment and possibly hydrogen bond(s) at the axial position of the hemin, along with favourable hydrophobic interactions for the periphery of the porphyrin ring. Third, the basic component of the buffer enhances the activities; this likely results from a general-base-catalyzed process. Cumulatively, these data supply important clues as to how biopolymers other than a protein can complex with hemin to form productive peroxidase enzymes.Key words: ribozyme, DNAzyme, hemin, peroxidase, mechanism, guanine quadruplex.

Self-assembly of gold nanoparticles in a block copolymer aggregate template driven by hydrophobic interactions

2019 ◽  
Vol 10 (46) ◽  
pp. 6269-6277
Author(s):  
Jong Dae Jang ◽  
Sang-Woo Jeon ◽  
Young-Jin Yoon ◽  
Joona Bang ◽  
Young Soo Han ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Block Copolymer ◽  
Self Assembly ◽  
Hydrophobic Interactions ◽  
Self Assembled

We report various self-assembled structures of gold nanoparticles in a block copolymer aggregate template, which are easily driven by hydrophobic interactions.

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