Structural Rationalization of a Large Difference in RNA Affinity Despite a Small Difference in Chemistry between Two 2‘-O-Modified Nucleic Acid Analogues

2004 ◽  
Vol 126 (46) ◽  
pp. 15006-15007 ◽  
Author(s):  
Rekha Pattanayek ◽  
Latsavongsakda Sethaphong ◽  
Chongle Pan ◽  
Marija Prhavc ◽  
Thazha P. Prakash ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Difference ◽  
Nucleic Acid Analogues

RNA interference with 2′,4′-bridged nucleic acid analogues

2010 ◽  
Vol 18 (10) ◽  
pp. 3474-3480 ◽  
Author(s):  
S.M. Abdur Rahman ◽  
Hiroyuki Sato ◽  
Naoto Tsuda ◽  
Sunao Haitani ◽  
Keisuke Narukawa ◽  
...  
Keyword(s):  
Rna Interference ◽  
Nucleic Acid ◽  
Nucleic Acid Analogues

scholarly journals Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 268
Author(s):  
Eleonóra Parelius Jonášová ◽  
Bjørn Torger Stokke
Keyword(s):  
Nucleic Acid ◽  
Optical Fibers ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Dna Oligonucleotides ◽  
Morpholino Oligonucleotides ◽  
Responsive Hydrogels ◽  
Nucleic Acid Analogues ◽  
Dna Hydrogels

Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility and numerous applications. The possibility to use nucleic acid analogues opens for further customization of the hydrogels. In the present work, the commonly employed DNA oligonucleotides in DNA-co-acrylamide responsive hydrogels are replaced by Morpholino oligonucleotides. The uncharged backbone of this nucleic acid analogue makes it less susceptible to possible enzymatic degradation. In this work we address fundamental issues related to key processes in the hydrogel response; such as partitioning of the free oligonucleotides and the strand displacement process. The hydrogels were prepared at the end of optical fibers for interferometric size monitoring and imaged using confocal laser scanning microscopy of the fluorescently labeled free oligonucleotides to observe their apparent diffusion and accumulation within the hydrogels. Morpholino-based hydrogels’ response to Morpholino targets was compared to DNA hydrogels’ response to DNA targets of the same base-pair sequence. Non-binding targets were observed to be less depleted in Morpholino hydrogels than in DNA hydrogels, due to their electroneutrality, resulting in faster kinetics for Morpholinos. The electroneutrality, however, also led to the total swelling response of the Morpholino hydrogels being smaller than that of DNA, since their lack of charges eliminates swelling resulting from the influx of counter-ions upon oligonucleotide binding. We have shown that employing nucleic acid analogues instead of DNA in hydrogels has a profound effect on the hydrogel response.

ChemInform Abstract: BNAs: Novel Nucleic Acid Analogues with a Bridged Sugar Moiety

ChemInform ◽  
2010 ◽  
Vol 33 (48) ◽  
pp. no-no
Author(s):  
Takeshi Imanishi ◽  
Satoshi Obika
Keyword(s):  
Nucleic Acid ◽  
Sugar Moiety ◽  
Nucleic Acid Analogues

Synthesis and Properties of Nucleic Acid Analogues Consisting of a Benzene—Phosphate Backbone.

ChemInform ◽  
2005 ◽  
Vol 36 (52) ◽  
Author(s):  
Yoshihito Ueno ◽  
Takumi Kato ◽  
Kumiko Sato ◽  
Yasutomo Ito ◽  
Mahito Yoshida ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Phosphate Backbone ◽  
Nucleic Acid Analogues

scholarly journals Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions

2014 ◽  
Vol 5 (10) ◽  
pp. 4076-4081 ◽  
Author(s):  
RuoWen Wang ◽  
Chunming Wang ◽  
Yang Cao ◽  
Zhi Zhu ◽  
Chaoyong Yang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Self Assembly ◽  
Hydrophobic Interactions ◽  
Acid Analogue ◽  
Nucleic Acid Analogues

An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented.

scholarly journals Comparison of Duplex Stabilizing Properties of 2′-Fluorinated Nucleic Acid Analogues with Furanose and Non-Furanose Sugar Rings

2014 ◽  
Vol 79 (18) ◽  
pp. 8877-8881 ◽  
Author(s):  
Michael E. Østergaard ◽  
Timothy Dwight ◽  
Andres Berdeja ◽  
Eric E. Swayze ◽  
Michael E. Jung ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Analogues
Sign in / Sign up

Export Citation Format

Share Document