Electrospun hydroxyethyl cellulose nanofibers functionalized with calcium phosphate coating for bone tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (37) ◽  
pp. 29497-29504 ◽  
Author(s):  
Sugandha Chahal ◽  
Fathima Shahitha Jahir Hussain ◽  
Anuj Kumar ◽  
Mashitah M. Yusoff ◽  
Mohammad Syaiful Bahari Abdull Rasad
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cellulose Nanofibers ◽  
Hydroxyethyl Cellulose ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Engineering Applications ◽  
Nanofibrous Scaffolds

Calcium phosphate coated HEC/PVA nanofibrous scaffolds for bone tissue engineering applications.

Bone regenerative engineering via controlled release of simple signaling molecules

2018 ◽  
Author(s):  
◽  
Soheila Aliakbarighavimi
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Critical Size ◽  
Calcium Phosphates ◽  
Signaling Molecules ◽  
Engineering Applications ◽  
Regenerative Engineering ◽  
Critical Size Defects

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] More than 1.7 billion people worldwide are suffering from bone defects that are due to trauma or medical conditions such as degenerative diseases. Bone can repair and remodel itself, however, in the case of critical size defects, healing is impossible without intervention. Bone regenerative engineering is a new field that focuses on the development of bone substitutes that can stimulate the body to remodel bone tissue in the defect site, most commonly utilizing calcium phosphates in their design to mimic the inorganic phase of bone. Most of previous research has overlooked that calcium phosphates consist of two non-proteinous signaling molecules calcium ions (Ca2+) and phosphate ions (Pi) which are referred as simple signaling molecules that are osteoinductive in a time-dependent and concentration-dependent manner. Higher concentrations of these ions are not only non-inductive, but are also cytotoxic. In my PhD research, I first identified the therapeutic range of Ca2+ and Pi after which I developed two novel platforms capable of controllably delivering these ions within their inductive therapeutic windows. The first platform was comprised of synthetic, hydrophobic, five-carbon polyesters incorporated with rapid dissoluting monobasic calcium phosphate as a scaffold for critical size defects in long bones. The second platform consisted of natural, hydrophilic, chitosan-based hydrogels incorporated with slow dissoluting dibasic calcium phosphate for the treatment of vertebral compression fractures. While I established a new aspect for controllably delivering Ca2+ and Pi as bioactive additives for different bone tissue engineering applications, we are interested in other simple signaling molecules as well. Moving forward, our research group is interested to investigate the effect of hydrogen sulfide (H2S), hydrogen peroxide (H2O2), and carbon monoxide (CO) as cytoprotective, angiogenic, and neuroinductive simple signaling molecules, respectively. The spatiotemporal delivery of multiple simple signaling molecules can be promising for complex bone tissue engineering applications.

scholarly journals Bioactive macro/micro porous silk fibroin/nano-sized calcium phosphate scaffolds with potential for bone-tissue-engineering applications

Nanomedicine ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. 359-378 ◽  
Author(s):  
Le-Ping Yan ◽  
Joana Silva-Correia ◽  
Cristina Correia ◽  
Sofia G Caridade ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Engineering Applications

scholarly journals Biomimetic Calcium Phosphate Coating as a Drug Delivery Vehicle for Bone Tissue Engineering: A Mini-Review

Coatings ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1118
Author(s):  
Xingnan Lin ◽  
Jiping Chen ◽  
Ying Liao ◽  
Janak Lal Pathak ◽  
Huang Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Defect ◽  
Drug Carrier ◽  
Calcium Phosphate Coating ◽  
Delivery Mode ◽  
Burst Release

The high incidence of bone defect cases necessitates a rapid development of cost-effective bone tissue engineering approaches. Bone growth factors such as bone morphogenetic protein-2 (BMP-2) play a vital role in bone tissue engineering. The osteoinductive efficacy of BMP-2 and other osteogenic growth factors is highly dependent on their dose and delivery mode. Slow and sustained delivery of a low dose of BMP-2 promotes bone defect healing. However, the burst release of a high dose of BMP-2 not only fails to promote bone healing but also causes adverse local and systemic effects. The biomimetic calcium phosphate (BioCaP) coating technique guarantees a slow, gradual, and local release of BMP-2 to mimic its natural release from the bone matrix under physiological conditions. Therefore, BioCaP coatings have long been regarded as a promising drug carrier for growth factors. In this mini-review, we give a brief introduction to BioCaP coatings regarding their preparation techniques, physicochemical properties, potential as a drug carrier, ability to suppress foreign body reactivity, and their preclinical application in ectopic and orthotopic models. Finally, the current challenges and future prospects of BioCaP coatings are discussed.

scholarly journals Nanofibrous Scaffolds Containing Hydroxyapatite and Microfluidic-Prepared Polyamidoamin/BMP-2 Plasmid Dendriplexes for Bone Tissue Engineering Applications

2020 ◽  
Vol Volume 15 ◽  
pp. 2633-2646 ◽  
Author(s):  
Mehdi Doosti-Telgerd ◽  
Fatemeh Sadat Mahdavi ◽  
Farzad Moradikhah ◽  
Mohammad Porgham Daryasari ◽  
Rahimeh Bayrami Atashgah ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications ◽  
Nanofibrous Scaffolds

scholarly journals Calcium-phosphate derived from mineralized algae for bone tissue engineering applications

2007 ◽  
Vol 61 (16) ◽  
pp. 3495-3499 ◽  
Author(s):  
Joaquim M. Oliveira ◽  
Jessica M.R. Grech ◽  
Isabel B. Leonor ◽  
João F. Mano ◽  
Rui L. Reis
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications
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