scholarly journals Bioactive macro/micro porous silk fibroin/nano-sized calcium phosphate scaffolds with potential for bone-tissue-engineering applications

Nanomedicine ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. 359-378 ◽  
Author(s):  
Le-Ping Yan ◽  
Joana Silva-Correia ◽  
Cristina Correia ◽  
Sofia G Caridade ◽  
Emanuel M Fernandes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Engineering Applications

Enhancing bioactive properties of silk fibroin with diatom particles for bone tissue engineering applications

2017 ◽  
Vol 12 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Thi Duy Hanh Le ◽  
Volha Liaudanskaya ◽  
Walter Bonani ◽  
Claudio Migliaresi ◽  
Antonella Motta
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Engineering Applications ◽  
Bioactive Properties

scholarly journals In vitro study of novel microparticle based silk fibroin scaffold with osteoblast-like cells for load-bearing osteo-regenerative applications

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26551-26558 ◽  
Author(s):  
Nimisha Parekh ◽  
Chandni Hushye ◽  
Saniya Warunkar ◽  
Sayam Sen Gupta ◽  
Anuya Nisal
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
In Vitro Study ◽  
Vitro Study ◽  
Engineering Applications ◽  
Load Bearing ◽  
Silk Fibroin Scaffold

Silk Fibroin microparticle scaffolds show promise in bone tissue engineering applications.

Bone regenerative engineering via controlled release of simple signaling molecules

2018 ◽  
Author(s):  
◽  
Soheila Aliakbarighavimi
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Critical Size ◽  
Calcium Phosphates ◽  
Signaling Molecules ◽  
Engineering Applications ◽  
Regenerative Engineering ◽  
Critical Size Defects

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] More than 1.7 billion people worldwide are suffering from bone defects that are due to trauma or medical conditions such as degenerative diseases. Bone can repair and remodel itself, however, in the case of critical size defects, healing is impossible without intervention. Bone regenerative engineering is a new field that focuses on the development of bone substitutes that can stimulate the body to remodel bone tissue in the defect site, most commonly utilizing calcium phosphates in their design to mimic the inorganic phase of bone. Most of previous research has overlooked that calcium phosphates consist of two non-proteinous signaling molecules calcium ions (Ca2+) and phosphate ions (Pi) which are referred as simple signaling molecules that are osteoinductive in a time-dependent and concentration-dependent manner. Higher concentrations of these ions are not only non-inductive, but are also cytotoxic. In my PhD research, I first identified the therapeutic range of Ca2+ and Pi after which I developed two novel platforms capable of controllably delivering these ions within their inductive therapeutic windows. The first platform was comprised of synthetic, hydrophobic, five-carbon polyesters incorporated with rapid dissoluting monobasic calcium phosphate as a scaffold for critical size defects in long bones. The second platform consisted of natural, hydrophilic, chitosan-based hydrogels incorporated with slow dissoluting dibasic calcium phosphate for the treatment of vertebral compression fractures. While I established a new aspect for controllably delivering Ca2+ and Pi as bioactive additives for different bone tissue engineering applications, we are interested in other simple signaling molecules as well. Moving forward, our research group is interested to investigate the effect of hydrogen sulfide (H2S), hydrogen peroxide (H2O2), and carbon monoxide (CO) as cytoprotective, angiogenic, and neuroinductive simple signaling molecules, respectively. The spatiotemporal delivery of multiple simple signaling molecules can be promising for complex bone tissue engineering applications.

scholarly journals Electrospun eri silk fibroin scaffold coated with hydroxyapatite for bone tissue engineering applications

2013 ◽  
Vol 2 (1) ◽  
pp. 6 ◽  
Author(s):  
Muthumanickkam Andiappan ◽  
Subramanian Sundaramoorthy ◽  
Niladrinath Panda ◽  
Gowri Meiyazhaban ◽  
Sofi Beaula Winfred ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Engineering Applications ◽  
Silk Fibroin Scaffold ◽  
Eri Silk

scholarly journals Calcium-phosphate derived from mineralized algae for bone tissue engineering applications

2007 ◽  
Vol 61 (16) ◽  
pp. 3495-3499 ◽  
Author(s):  
Joaquim M. Oliveira ◽  
Jessica M.R. Grech ◽  
Isabel B. Leonor ◽  
João F. Mano ◽  
Rui L. Reis
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Engineering Applications
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