Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16940-16949 ◽  
Author(s):  
Rui Zhao ◽  
Xiang Li ◽  
Bolun Sun ◽  
Yan Tong ◽  
Ziqiao Jiang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Fiber Mats ◽  
Good Antibacterial Activity ◽  
Nanofiber Mats ◽  
Layer Fiber

Dual-layer nitrofurazone-loaded nanofiber mats are fabricated by electrospinning with good antibacterial activity and the mats perform well in wound healing.

Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

2017 ◽  
Vol 18 (11) ◽  
pp. 3766-3775 ◽  
Author(s):  
Qing Li ◽  
Fei Lu ◽  
Guofang Zhou ◽  
Kun Yu ◽  
Bitao Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Gold Nanoparticle ◽  
Wound Dressing

scholarly journals Emulsion Electrospun Fiber Mats of PCL/PVA/Chitosan and Eugenol for Wound Dressing Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Cláudia Mouro ◽  
Manuel Simões ◽  
Isabel C. Gouveia
Keyword(s):  
Contact Angle ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Electrospun Fiber ◽  
Total Porosity ◽  
Dermal Fibroblasts ◽  
Wound Management ◽  
Water Contact ◽  
Fiber Mats

In recent years, the damaging effects of antimicrobial resistance relating to wound management and infections have driven the ongoing development of composite wound dressing mats containing natural compounds, such as plant extracts and their derivatives. The present research reports the fabrication of novel electrospun Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)/Chitosan (CS) fiber mats loaded with Eugenol (EUG), an essential oil, known for its therapeutic properties. The electrospun fiber mats were prepared via electrospinning from either water-in-oil (W/O) or oil-in-water (O/W) emulsions and characterized using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), total porosity measurements, and water contact angle. The in vitro EUG release profile and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa were also evaluated. The obtained results proved that the EUG was loaded efficiently into electrospun PCL/PVA/CS fiber mats and the two W/O and O/W emulsions prepared from the PCL/PVA/CS (7 : 3 : 1) and PCL/PVA/CS (3 : 7 : 1) revealed porosity within the ideal range of 60–90%, even when EUG was loaded. The measured contact angle values showed that the O/W emulsion exhibited a more hydrophilic character and the wettability noticeably decreased after adding EUG in both emulsion blends. Furthermore, the electrospun PCL/PVA/CS fiber mats demonstrated a rapid release of EUG during the first 8 hours, which enhanced gradually afterward (up to 120 hours). Moreover, an efficient antibacterial activity against S. aureus (inhibition ratios of 92.43% and 83.08%) and P. aeruginosa (inhibition ratios of 94.68% and 87.85%) was displayed and the in vitro cytotoxic assay demonstrated that the normal human dermal fibroblasts (NHDF) remained viable for at least 7 days, after direct contact with the produced electrospun fiber mats. Therefore, such findings support the biocompatibility and suitability of using these EUG-loaded electrospun PCL/PVA/CS fiber mats as a new innovative wound dressing material with potential for preventing and treating microbial wound infections.

scholarly journals A freeze–thaw PVA hydrogel loaded with guava leaf extract: physical and antibacterial properties

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 30156-30171
Author(s):  
William Xaveriano Waresindo ◽  
Halida Rahmi Luthfianti ◽  
Dhewa Edikresnha ◽  
Tri Suciati ◽  
Fatimah Arofiati Noor ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Freeze Thaw ◽  
Good Antibacterial Activity ◽  
Potential Applications ◽  
Guava Leaf ◽  
Pva Hydrogel

A polyvinyl alcohol (PVA) hydrogel loaded with guava leaf extract (GLE) has potential applications as a wound dressing with good antibacterial activity.

Novel chitin/chitosan-glucan wound dressing: Isolation, characterization, antibacterial activity and wound healing properties

2016 ◽  
Vol 510 (1) ◽  
pp. 86-99 ◽  
Author(s):  
A.M. Abdel-Mohsen ◽  
J. Jancar ◽  
D. Massoud ◽  
Z. Fohlerova ◽  
H. Elhadidy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing

Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing

RSC Advances ◽  
2014 ◽  
Vol 4 (104) ◽  
pp. 60114-60122 ◽  
Author(s):  
Weibin Ma ◽  
Xianyan Yang ◽  
Liang Ma ◽  
Xingang Wang ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Water Uptake ◽  
Wound Dressing ◽  
Chronic Wound ◽  
Uptake Capacity ◽  
Water Uptake Capacity ◽  
Nanofibrous Membranes

Bioactive glass-introduced gelatin/chitosan nanofibrous dressings were developedviaelectrospinning to endow improved antibacterial activity, adjustable bioactivity and water uptake capacity for enhancing chronic wound healing.

Wound-dressing materials with antibacterial activity from electrospun polyurethane–dextran nanofiber mats containing ciprofloxacin HCl

2012 ◽  
Vol 90 (4) ◽  
pp. 1786-1793 ◽  
Author(s):  
Afeesh R. Unnithan ◽  
Nasser A.M. Barakat ◽  
P.B. Tirupathi Pichiah ◽  
Gopalsamy Gnanasekaran ◽  
R. Nirmala ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Wound Dressing ◽  
Nanofiber Mats ◽  
Dressing Materials ◽  
Wound Dressing Materials

scholarly journals Development of wound dressing film using methanolic extracts of freshwater microalgae and determining its wound healing ability

2021 ◽  
pp. 166-173
Author(s):  
S. Soundararajan ◽  
R. Karkuvel Raja ◽  
S. Vishnu Chitthan ◽  
S. Sanjay Prasad ◽  
N. Thajuddin
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Chemical Properties ◽  
Freshwater Microalgae ◽  
Chlorella Sp ◽  
Methanolic Extracts ◽  
Freshwater Habitats ◽  
Pure Cultures

Wound healing is a complex process in which bacterial infection is a major cause for delayed wound healing. Occurrence of drug resistance among bacterial pathogens led to discovery of new antimicrobial agents from new sources. The present study aimed to identify microalgal metabolites with antibacterial activity and to develop a wound dressing film with their potential healing activity. Microalgal samples were collected from three different freshwater habitats, isolated, made them pure cultures and physico-chemical properties of water samples from the respective sampling sites were analzed. Among the three microalgal isolates,  Chlorella sp. NRMC-F-0350 showed antibacterial activity against clinical isolates of  E. coli, Klebsiella pneumoniae and Staphylococcus aureus. Additionally, functional groups present in Chlorella sp. NRMC-F-0350 were identified using FTIR and GC-MS analysis. Several antibacterial compounds viz. benzoxazole, 1,2 Benzene dicarboxylic acid, sistosterol, 9-Octadecanoic acid, eicosane and hexadecane were identified. Wound dressing films were developed and showed evident antibacterial as well as significant wound healing activity (84.5%). Therefore, the developed films can be used as a potential wound dressing material. 

scholarly journals An Injectable Chitosan-Based Self-Healable Hydrogel System as An Antibacterial Wound Dressing

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 5956
Author(s):  
Xiaoyu Wang ◽  
Rijian Song ◽  
Melissa Johnson ◽  
Sigen A ◽  
Zhonglei He ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Wound Dressing ◽  
Cost Effective ◽  
Hek 293 ◽  
293 Cells ◽  
Good Biocompatibility ◽  
Crosslinking Agents ◽  
Hydrogel System

Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, and genipin. Therefore, we developed a biocompatible yet cost-effective chitosan-based hydrogel system as a candidate biomaterial to prevent infection during wound healing. The hydrogel was fabricated by crosslinking chitosan with dialdehyde chitosan (CTS–CHO) via dynamic Schiff-base reactions, resulting in a self-healable and injectable system. The rheological properties, degradation profile, and self-healable properties of the chitosan-based hydrogel were evaluated. The excellent antibacterial activity of the hydrogel was validated by a spread plate experiment. The use of Live/Dead assay on HEK 293 cells showed that the hydrogel exhibited excellent biocompatibility. The results demonstrate that the newly designed chitosan-based hydrogel is an excellent antibacterial wound dressing candidate with good biocompatibility.

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