Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing

RSC Advances ◽  
2014 ◽  
Vol 4 (104) ◽  
pp. 60114-60122 ◽  
Author(s):  
Weibin Ma ◽  
Xianyan Yang ◽  
Liang Ma ◽  
Xingang Wang ◽  
Lei Zhang ◽  
...  

Bioactive glass-introduced gelatin/chitosan nanofibrous dressings were developedviaelectrospinning to endow improved antibacterial activity, adjustable bioactivity and water uptake capacity for enhancing chronic wound healing.

Author(s):  
Laleh Asadi ◽  
Javad Mokhtari ◽  
Marjan Abbasi

AbstractWound dressing should be impenetrable against microorganisms and it should keep the wound wet. Gauze and polyamide (PA) substrate were treated with various concentrations of AgNPs (25, 50, 75, and 100 ppm), PHMB (0.2, 0.4, 0.6, 0.8, and 1% w/v), and constant concentration of alginate (0.5% W/V) using a simple dipping method. Prepared samples were characterized by various techniques including Fourier transform infrared spectroscopy and scanning electron microscopy. The results indicated that the particles were successfully applied onto both substrates with an average diameter of particle size of 78 nm on gauze and 172 nm on the PA substrate surface (based on 50 nanoparticles). Antibacterial activity of the prepared nanocomposite against Staphylococcus aureus (gram-positive) bacteria on PA substrate and gauze were evaluated using the disc diffusion method. The results indicated that the prepared nanocomposites offer favorable antibacterial properties and bacteria would not grow in culture media. The water uptake capacity test of the treated samples was assessed and the data demonstrated that the water absorption rate significantly increases on both treated substrates (gauze and PA substrate) due to the presence of alginate polymer. Also, observing the results of the coagulation test showed that treated samples caused blood clots on the dressing. This is due to the presence of alginate polymer. The present work demonstrates that the prepared samples offer excellent antibacterial properties and good water uptake capacity that capable of being a potential candidate for wound dressings. Due to the results, the produced PA substrate could be an appropriate replacement for the cotton gauze as a wound dressing.


Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 772
Author(s):  
Estefanía Álvarez-Castillo ◽  
Carlos Bengoechea ◽  
Antonio Guerrero

The replacement of common acrylic derivatives by biodegradable materials in the formulation of superabsorbent materials would lessen the associated environmental impact. Moreover, the use of by-products or biowastes from the food industry that are usually discarded would promote a desired circular economy. The present study deals with the development of superabsorbent materials based on a by-product from the meat industry, namely plasma protein, focusing on the effects of a freeze-drying stage before blending with glycerol and eventual injection molding. More specifically, this freeze-drying stage is carried out either directly on the protein flour or after its solubilization in deionized water (10% w/w). Superabsorbent materials obtained after this solubilization-freeze-drying process display higher Young’s modulus and tensile strength values, without affecting their water uptake capacity. As greater water uptake is commonly related to poorer mechanical properties, the proposed solubilization-freeze-drying process is a useful strategy for producing strengthened hydrophilic materials.


2016 ◽  
Vol 7 (14) ◽  
pp. 2553-2564 ◽  
Author(s):  
Yating Jia ◽  
Weizhong Wang ◽  
Xiaojun Zhou ◽  
Wei Nie ◽  
Liang Chen ◽  
...  

A poly(glycerol sebacate)-based elastomeric copolyesters with improved mechanical properties and higher water uptake capacity.


2017 ◽  
Vol 18 (11) ◽  
pp. 3766-3775 ◽  
Author(s):  
Qing Li ◽  
Fei Lu ◽  
Guofang Zhou ◽  
Kun Yu ◽  
Bitao Lu ◽  
...  

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16940-16949 ◽  
Author(s):  
Rui Zhao ◽  
Xiang Li ◽  
Bolun Sun ◽  
Yan Tong ◽  
Ziqiao Jiang ◽  
...  

Dual-layer nitrofurazone-loaded nanofiber mats are fabricated by electrospinning with good antibacterial activity and the mats perform well in wound healing.


Pharmaceutics ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 8 ◽  
Author(s):  
Selenia Ternullo ◽  
Laura Victoria Schulte Werning ◽  
Ann Mari Holsæter ◽  
Nataša Škalko-Basnet

A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel’s hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system’s bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.


2017 ◽  
Vol 19 (38) ◽  
pp. 26132-26144 ◽  
Author(s):  
Akhil Pratap Singh ◽  
Kaushik Kundu ◽  
Vikram Singh ◽  
Ramesh L. Gardas ◽  
Sanjib Senapati

In view of this limited research on pILs in microemulsions, here we study the formation and characterization of a series of pIL–water/oil microemulsions with specific questions on the effect of pILs on water uptake capacity and thermal stability of W/O microemulsions.


Clay Minerals ◽  
2011 ◽  
Vol 46 (3) ◽  
pp. 411-420 ◽  
Author(s):  
S. Kaufhold ◽  
R. Dohrmann ◽  
K. Ufer ◽  
R. Kleeberg ◽  
H. Stanjek

AbstractThe Cu-triethylenetetramine-complex (Cutrien) is one of the commonly used index cations for CEC determination in clay science. Cutrien-exchanged smectites show basal spacings between 13.0 and 13.5 Å after correction for the Lorentz and polarization factors. The full width at half maximum (FWHM) of the d001 reflection is today related to the percentage of tetrahedral charge (beidellitic character) and/or to the Fe content of the smectites. The structural Fe content and the tetrahedral charge correlate, so their individual influence on d001 cannot be resolved. Nevertheless, the FWHM of Cutrien smectites should depend on the charge distribution rather than the Fe content.X-ray diffraction (XRD) and water uptake capacity measurements showed that the interlayer of Cutrien-exchanged smectites does not swell any more, but can take up a few water molecules. Accordingly, the water uptake capacity of the external surface area can be determined independently from the interlayer water uptake capacity. Adjusting the pH of Cutrien-bentonite dispersion to different values allows for the determination of the variable charge.In conclusion, Cutrien exchange of smectites appears to be suitable for the study of external surfaces area related phenomena (e.g. edge adsorption processes) without any influence of the interlayer region.


2015 ◽  
Vol 44 (5) ◽  
pp. 2047-2051 ◽  
Author(s):  
Nakeun Ko ◽  
Jisu Hong ◽  
Siyoung Sung ◽  
Kyle E. Cordova ◽  
Hye Jeong Park ◽  
...  

The functionalization of the metal–organic framework, UiO-67, with –NH2 groups is proven effective for increasing the water uptake capacity at low relative pressure at 298 K.


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