A brief case study demonstrating the applicability of MALDI mass spectrometry for detecting bacteria in dental samples

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14090-14094 ◽  
Author(s):  
Judy Gopal ◽  
Hui-Fen Wu
Keyword(s):  
Mass Spectrometry ◽  
Maldi Mass Spectrometry ◽  
Maldi Ms ◽  
Dental Infection ◽  
Ms Detection

MALDI-MS detection of bacteria in dental infection.

Matrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS): basics and clinical applications

2020 ◽  
Vol 58 (6) ◽  
pp. 883-896 ◽  
Author(s):  
Muhammad Zubair Israr ◽  
Dennis Bernieh ◽  
Andrea Salzano ◽  
Shabana Cassambai ◽  
Yoshiyuki Yazaki ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Laser Desorption ◽  
Maldi Mass Spectrometry ◽  
Clinical Applications ◽  
Clinical Diagnostics ◽  
Maldi Ms ◽  
Therapeutic Drug ◽  
The Impact ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

AbstractBackgroundMatrix-assisted laser desorption ionisation (MALDI) mass spectrometry (MS) has been used for more than 30 years. Compared with other analytical techniques, it offers ease of use, high throughput, robustness, cost-effectiveness, rapid analysis and sensitivity. As advantages, current clinical techniques (e.g. immunoassays) are unable to directly measure the biomarker; rather, they measure secondary signals. MALDI-MS has been extensively researched for clinical applications, and it is set for a breakthrough as a routine tool for clinical diagnostics.ContentThis review reports on the principles of MALDI-MS and discusses current clinical applications and the future clinical prospects for MALDI-MS. Furthermore, the review assesses the limitations currently experienced in clinical assays, the advantages and the impact of MALDI-MS to transform clinical laboratories.SummaryMALDI-MS is widely used in clinical microbiology for the screening of microbial isolates; however, there is scope to apply MALDI-MS in the diagnosis, prognosis, therapeutic drug monitoring and biopsy imaging in many diseases.OutlookThere is considerable potential for MALDI-MS in clinic as a tool for screening, profiling and imaging because of its high sensitivity and specificity over alternative techniques.

MALDI mass spectrometry for probing the anti- staphylococcal capability of TiO2nanoparticles via near-UV and laser irradiation

2015 ◽  
Vol 39 (6) ◽  
pp. 4909-4918 ◽  
Author(s):  
Judy Gopal ◽  
Jayaram Lakshmaiah Narayana ◽  
Nazim Hasan ◽  
Hui-Fen Wu
Keyword(s):  
Mass Spectrometry ◽  
Laser Irradiation ◽  
Maldi Mass Spectrometry ◽  
Maldi Ms ◽  
First Time

We report the use of MALDI-MS as an effective tool in investigating the anti-staphylococcal property of TiO2nanoparticles under near-UV and for the first time also under laser irradiation.

scholarly journals An update on MALDI mass spectrometry based technology for the analysis of fingermarks – stepping into operational deployment

The Analyst ◽  
2017 ◽  
Vol 142 (14) ◽  
pp. 2518-2546 ◽  
Author(s):  
S. Francese ◽  
R. Bradshaw ◽  
N. Denison
Keyword(s):  
Mass Spectrometry ◽  
Maldi Mass Spectrometry ◽  
Maldi Ms ◽  
Operational Capabilities

Expanded range of retrievable intelligence from fingermarksviaMALDI MS based methods and increased operational capabilities of the technology.

Time-dependent cortisol turnover in tissues using stable isotope tracers and MALDI Mass Spectrometry (MS) sampling

2018 ◽  
Author(s):  
Shazia Khan ◽  
Diego F Cobice ◽  
Dawn EW Livingstone ◽  
C Logan Mackay ◽  
Scott P Webster ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Maldi Mass Spectrometry ◽  
Time Dependent ◽  
Stable Isotope Tracers ◽  
Isotope Tracers

Algorithm of combining chromatography mass spectrometry-untargeted profiling and multivariate analysis for identification of marker-substances in samples of complex composition

2020 ◽  
Vol 86 (7) ◽  
pp. 12-19
Author(s):  
I. V. Plyushchenko ◽  
D. G. Shakhmatov ◽  
I. A. Rodin
Keyword(s):  
Mass Spectrometry ◽  
Multivariate Analysis ◽  
Large Scale ◽  
Complex Composition ◽  
Unified Protocol ◽  
Chromatography Mass Spectrometry ◽  
Marker Substances ◽  
Selection Testing ◽  
Untargeted Profiling

A viral development of statistical data processing, computing capabilities, chromatography-mass spectrometry, and omics technologies (technologies based on the achievements of genomics, transcriptomics, proteomics, metabolomics) in recent decades has not led to formation of a unified protocol for untargeted profiling. Systematic errors reduce the reproducibility and reliability of the obtained results, and at the same time hinder consolidation and analysis of data gained in large-scale multi-day experiments. We propose an algorithm for conducting omics profiling to identify potential markers in the samples of complex composition and present the case study of urine samples obtained from different clinical groups of patients. Profiling was carried out by the method of liquid chromatography mass spectrometry. The markers were selected using methods of multivariate analysis including machine learning and feature selection. Testing of the approach was performed using an independent dataset by clustering and projection on principal components.

Application of Carbon Matrices to Screening Pentacylic Triterpenoids in Plant Feedstock by MALDI Mass Spectrometry

2020 ◽  
Vol 75 (14) ◽  
pp. 1749-1757
Author(s):  
E. A. Anikeenko ◽  
E. N. Rakhmatullina ◽  
D. I. Falev ◽  
O. Yu. Khoroshev ◽  
N. V. Ul’yanovskii ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Maldi Mass Spectrometry ◽  
Plant Feedstock
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