Toward point-of-care diagnostics with consumer electronic devices: the expanding role of nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22256-22282 ◽  
Author(s):  
Eleonora Petryayeva ◽  
W. Russ Algar
Keyword(s):  
Point Of Care ◽  
Cell Phones ◽  
Electronic Devices ◽  
Point Of Care Diagnostics ◽  
Consumer Electronic

A review of the role that nanoparticles can play in point-of-care diagnostics that utilize consumer electronic devices such as cell phones and smartphones for readout, including an overview of important concepts and examples from the literature.

scholarly journals Population-Based Screening for Atrial Fibrillation

2020 ◽  
Vol 127 (1) ◽  
pp. 143-154 ◽  
Author(s):  
Shaan Khurshid ◽  
Jeffrey S. Healey ◽  
William F. McIntyre ◽  
Steven A. Lubitz
Keyword(s):  
Atrial Fibrillation ◽  
Current Literature ◽  
Oral Anticoagulation ◽  
Electronic Devices ◽  
Population Based ◽  
Consensus Guidelines ◽  
Consumer Electronic ◽  
Receive Treatment

Atrial fibrillation (AF) is a common and morbid arrhythmia. Stroke is a major hazard of AF and may be preventable with oral anticoagulation. Yet since AF is often asymptomatic, many individuals with AF may be unaware and do not receive treatment that could prevent a stroke. Screening for AF has gained substantial attention in recent years as several studies have demonstrated that screening is feasible. Advances in technology have enabled a variety of approaches to facilitate screening for AF using both medical-prescribed devices as well as consumer electronic devices capable of detecting AF. Yet controversy about the utility of AF screening remains owing to concerns about potential harms resulting from screening in the absence of randomized data demonstrating effectiveness of screening on outcomes such as stroke and bleeding. In this review, we summarize current literature, present technology, population-based screening considerations, and consensus guidelines addressing the role of AF screening in practice.

Deciphering the Role of Nanostructured Materials in the Point-of-Care Diagnostics for COVID-19: A Comprehensive Review

2021 ◽  
Author(s):  
Saravanan Krishnan ◽  
Apurva Dusane ◽  
Rasmi Morajkar ◽  
Akila Venkat ◽  
Amit Vernekar
Keyword(s):  
Working Class ◽  
Nanostructured Materials ◽  
Point Of Care ◽  
Comprehensive Review ◽  
Point Of Care Diagnostics

The infamous COVID-19 outbreak has left a crippling impact on the economy, healthcare infrastructure and lives of the general working class; with all the scientists determined to find suitable and...

scholarly journals Towards a Smart Encapsulation System for Small-Sized Electronic Devices: A New Approach

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Sebastian-Tim Schmitz-Hertzberg ◽  
Rick Liese ◽  
Carsten Terjung ◽  
Frank F. Bier
Keyword(s):  
Point Of Care ◽  
Electronic Devices ◽  
Protective Shell ◽  
New Approach ◽  
Point Of Care Diagnostics ◽  
Target Analytes ◽  
Diffusion Rates ◽  
Different Diameters ◽  
Electrical Components ◽  
Insight Into

Miniaturized analytical chip devices like biosensors nowadays provide assistance in highly diverse fields of application such as point-of-care diagnostics and industrial bioprocess engineering. However, upon contact with fluids, the sensor requires a protective shell for its electrical components that simultaneously offers controlled access for the target analytes to the measuring units. We therefore developed a capsule that comprises a permeable and a sealed compartment consisting of variable polymers such as biocompatible and biodegradable polylactic acid (PLA) for medical applications or more economical polyvinyl chloride (PVC) and polystyrene (PS) polymers for bioengineering applications. Production of the sealed capsule compartments was performed by heat pressing of polymer pellets placed in individually designable molds. Controlled permeability of the opposite compartments was achieved by inclusion of NaCl inside the polymer matrix during heat pressing, followed by its subsequent release in aqueous solution. Correlating diffusion rates through the so made permeable capsule compartments were quantified for preselected model analytes: glucose, peroxidase, and polystyrene beads of three different diameters (1.4 μm, 4.2 μm, and 20.0 μm). In summary, the presented capsule system turned out to provide sufficient shelter for small-sized electronic devices and gives insight into its potential permeability for defined substances of analytical interest.

scholarly journals Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics

Biosensors ◽  
2015 ◽  
Vol 5 (3) ◽  
pp. 577-601 ◽  
Author(s):  
Shikha Sharma ◽  
Julia Zapatero-Rodríguez ◽  
Pedro Estrela ◽  
Richard O'Kennedy
Keyword(s):  
Present Status ◽  
Point Of Care ◽  
Low Resource Settings ◽  
Future Role ◽  
Low Resource ◽  
Point Of Care Diagnostics

The expanding role of paper in point-of-care diagnostics

2014 ◽  
Vol 14 (2) ◽  
pp. 123-125 ◽  
Author(s):  
Scott T Phillips ◽  
Gregory G Lewis
Keyword(s):  
Point Of Care ◽  
Point Of Care Diagnostics

scholarly journals Nanozymes in Point-of-Care Diagnosis: An Emerging Futuristic Approach for Biosensing

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Bhaskar Das ◽  
Javier Lou Franco ◽  
Natasha Logan ◽  
Paramasivan Balasubramanian ◽  
Moon Il Kim ◽  
...  
Keyword(s):  
Surface Chemistry ◽  
Point Of Care ◽  
Low Cost ◽  
Metal Organic Framework ◽  
World Health ◽  
Point Of Care Diagnostics ◽  
Enzyme Mimicking ◽  
Wide Range ◽  
Metal Metal

AbstractNanomaterial-based artificial enzymes (or nanozymes) have attracted great attention in the past few years owing to their capability not only to mimic functionality but also to overcome the inherent drawbacks of the natural enzymes. Numerous advantages of nanozymes such as diverse enzyme-mimicking activities, low cost, high stability, robustness, unique surface chemistry, and ease of surface tunability and biocompatibility have allowed their integration in a wide range of biosensing applications. Several metal, metal oxide, metal–organic framework-based nanozymes have been exploited for the development of biosensing systems, which present the potential for point-of-care analysis. To highlight recent progress in the field, in this review, more than 260 research articles are discussed systematically with suitable recent examples, elucidating the role of nanozymes to reinforce, miniaturize, and improve the performance of point-of-care diagnostics addressing the ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable to the end user) criteria formulated by World Health Organization. The review reveals that many biosensing strategies such as electrochemical, colorimetric, fluorescent, and immunological sensors required to achieve the ASSURED standards can be implemented by using enzyme-mimicking activities of nanomaterials as signal producing components. However, basic system functionality is still lacking. Since the enzyme-mimicking properties of the nanomaterials are dictated by their size, shape, composition, surface charge, surface chemistry as well as external parameters such as pH or temperature, these factors play a crucial role in the design and function of nanozyme-based point-of-care diagnostics. Therefore, it requires a deliberate exertion to integrate various parameters for truly ASSURED solutions to be realized. This review also discusses possible limitations and research gaps to provide readers a brief scenario of the emerging role of nanozymes in state-of-the-art POC diagnosis system development for futuristic biosensing applications.

scholarly journals COVID-19 Point-of-Care Diagnostics: Present and Future

ACS Nano ◽  
2021 ◽  
Author(s):  
Enrique Valera ◽  
Aaron Jankelow ◽  
Jongwon Lim ◽  
Victoria Kindratenko ◽  
Anurup Ganguli ◽  
...  
Keyword(s):  
Point Of Care ◽  
Point Of Care Diagnostics

scholarly journals 145 Point of care lung ultrasound in patient triage: integration of ultrasound into a streaming pathway for COVID-19

2020 ◽  
Vol 37 (12) ◽  
pp. 839.1-839
Author(s):  
Dominic Craver ◽  
Aminah Ahmad ◽  
Anna Colclough
Keyword(s):  
Point Of Care ◽  
District General Hospital ◽  
Training Programme ◽  
Service Evaluation ◽  
University Hospital ◽  
Junior Doctors ◽  
Point Of Care Ultrasound ◽  
Face To Face ◽  
Point Of Care Diagnostics ◽  
Audit Data

Aims/Objectives/BackgroundRapid risk stratification of patients is vital for Emergency Department (ED) streaming during the COVID-19 pandemic. Ideally, patients should be split into red (suspected/confirmed COVID-19) and green (non COVID-19) zones in order to minimise the risk of patient-to-patient and patient-to-staff transmission. A robust yet rapid streaming system combining clinician impression with point-of-care diagnostics is therefore necessary.Point of care ultrasound (POCUS) findings in COVID-19 have been shown to correlate well with computed tomography (CT) findings, and it therefore has value as a front-door diagnostic tool. At University Hospital Lewisham (a district general hospital in south London), we recognised the value of early POCUS and its potential for use in patient streaming.Methods/DesignWe developed a training programme, ‘POCUS for COVID’ and subsequently integrated POCUS into streaming of our ED patients. The training involved Zoom lectures, a face to face practical, a 10 scan sign off process followed by a final triggered assessment. Patient outcomes were reviewed in conjunction with their scan reports.Results/ConclusionsCurrently, we have 21 ED junior doctors performing ultrasound scans independently, and all patients presenting to our department are scanned either in triage or in the ambulance. A combination of clinical judgement and scan findings are used to stream the patient to an appropriate area.Service evaluation with analysis of audit data has found our streaming to be 94% sensitive and 79% specific as an indicator of COVID 19. Further analysis is ongoing.Here we present both the structure of our training programme and our integrated streaming pathway along with preliminary analysis results.

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