scholarly journals One-pot aqueous synthesis of highly strained CdTe/CdS/ZnS nanocrystals and their interactions with cells

RSC Advances ◽  
2015 ◽  
Vol 5 (10) ◽  
pp. 7485-7494 ◽  
Author(s):  
Mehriban Ulusoy ◽  
Johanna-Gabriela Walter ◽  
Antonina Lavrentieva ◽  
Imme Kretschmer ◽  
Lydia Sandiford ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Targeted Imaging ◽  
Thick Shell ◽  
One Pot ◽  
Aqueous Synthesis ◽  
Small Core ◽  
Cds Nanocrystals ◽  
Zns Nanocrystals ◽  
Highly Strained

An aqueous approach enhancing the properties of small-core/thick-shell CdTe/CdS nanocrystals by deposition of an outer ZnS shell was developed. The as-prepared nanocrystals were conjugated with aptamer for the targeted imaging of cancer cells.

Microwave-assisted aqueous synthesis of new quaternary-alloyed CdSeTeS quantum dots; and their bioapplications in targeted imaging of cancer cells

Luminescence ◽  
2012 ◽  
Vol 28 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Fengzhao Yang ◽  
Zhancheng Xu ◽  
Jinjie Wang ◽  
Feng Zan ◽  
Chaoqing Dong ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cancer Cells ◽  
Targeted Imaging ◽  
Aqueous Synthesis ◽  
Microwave Assisted

Rapid aqueous synthesis of CuInS/ZnS quantum dots as sensor probe for alkaline phosphatase detection and targeted imaging in cancer cells

Talanta ◽  
2018 ◽  
Vol 189 ◽  
pp. 411-417 ◽  
Author(s):  
Fangmei Zhang ◽  
Xu He ◽  
Pinyi Ma ◽  
Ying Sun ◽  
Xinghua Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Alkaline Phosphatase ◽  
Cancer Cells ◽  
Targeted Imaging ◽  
Aqueous Synthesis ◽  
Sensor Probe

Novel multifunctional nano-hybrid polyhedral oligomeric silsesquioxane-based molecules with high cell permeability: molecular design and application for diagnosis and treatment of tumors

Nanoscale ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 2982-2994
Author(s):  
Gang Wei ◽  
Kezhen Zhang ◽  
Yuanlong Gu ◽  
Shanyi Guang ◽  
Jihong Feng ◽  
...  
Keyword(s):  
Folic Acid ◽  
Molecular Design ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Cell Permeability ◽  
Targeted Imaging ◽  
High Cell ◽  
One Pot ◽  
Peg 400 ◽  
Multifunctional Molecules ◽  
Oligomeric Silsesquioxane

Octathiol POSS was used to connect PEG-400, hexene, folic acid, fluorescein, and thioguanine using a simple and efficient photo-initiated one-pot method to prepare multifunctional molecules, which have targeted imaging and therapeutic functions.

scholarly journals Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

2021 ◽  
Vol 16 (4) ◽  
pp. 1934578X2110100
Author(s):  
Pham The Chinh ◽  
Pham Thi Tham ◽  
Duong Huong Quynh ◽  
Nguyen Van Tuyen ◽  
Dinh Thuy Van ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Aldol Condensation ◽  
One Pot ◽  
Aryl Group ◽  
Vascular Disrupting Agents ◽  
Benzaldehyde Derivatives ◽  
Vascular Disrupting

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), and ( Z)−3-(( Z)−4-chlorobenzylidene)−1,4-dimethyl-6-((8-methyl-4-nitroquinolin-2-yl)methylene)piperazine-2,5-dione (8) showed strong cytotoxicity against 3 of the cancer cells lines (KB, HepG2 and Lu) with IC50 values ranging from 3.04 to 10.62 µM. The quinoline-derived compounds had higher cytotoxic activity than the benzaldehyde derivatives. The successful synthesis of these derivatives offers useful information for the development of more potent vascular disrupting agents based on plinabulin.

One Pot Aqueous Synthesis of L-Histidine Amino Acid Capped Mn: ZnS Quantum Dots for Dopamine Sensing

2020 ◽  
Vol 16 (1) ◽  
pp. 71-78 ◽  
Author(s):  
Ravi Arunan ◽  
Printo Joseph ◽  
Muthusamy Sivakumar ◽  
Suthanthira Cross Guevara Kiruba Daniel
Keyword(s):  
Amino Acid ◽  
Quantum Dot ◽  
Colorimetric Sensing ◽  
One Pot ◽  
Aqueous Synthesis ◽  
Capping Agents ◽  
Average Size ◽  
The Right ◽  
Functional Group Modification ◽  
Mn Doped

Background: Mn doped ZnS is selected as the right element which is prominent among quantum dot for its high luminescent and quantum yield property and also non toxicity while comparing with other organometallic quantum dot synthesized by using different capping agents. Methods: An interesting observation based on colorimetric sensing of dopamine using manganese doped zinc sulfide quantum dot is discussed in this study. Mn doped ZnS quantum dot surface passivated with capping agents such as L-histidine and also in polymers like chitosan, PVA and PVP were studied and compared. The tunable fluorescence effect was also observed in different polymers and amino acid as capping agents. Optical characterization studies like UV-Visible spectroscopy and PL spectroscopy have been carried out. The functional group modification of Quantum dot has been analyzed using FTIR and size and shape analysis was conducted by using HRTEM image. Result: The strong and broad peak of FTIR in the range of 3500-3300 cm-1 confirms the presence of O-H bond. It is also observed that quenching phenomena in the luminescent peak are due to weaker confinement effect. The average size of the particle is shown to be around 4-5 nm. Changes in color of the quantum dot solution from transparent to dark brown has been due to the interaction with dopamine. Conclusion: Finally, L-Histidine amino acid capped Mn:ZnS shows better results in luminescence and size confinement properties. Hence, it was chosen for dopamine sensing due to its colloidal nature and inborn affinity towards dopamine, a neurotransmitter which is essential for early diagnosis of neural diseases

scholarly journals Synthesis, Characterization and Anticancer Evaluation of Nitrogen Substituted 1-(3-Aminoprop-1-ynyl)-4-Hydroxyanthraquinone Derivatives

2021 ◽  
Author(s):  
Nafisa S. Sirazhetdinova ◽  
Dmitry S Baev ◽  
Victor A. Savelyev ◽  
Tatyana S. Golubeva ◽  
Lyubov S. Klimenko ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Sonogashira Reaction ◽  
Secondary Amines ◽  
One Pot ◽  
Standard Drug ◽  
Three Component Reaction ◽  
G Quadruplex ◽  
New Compounds ◽  
Substituted 1 ◽  
Mcf 7

Abstract Anthraquinones are of significant interest due to their biological activity, coloring properties and synthetic applications. Here, we describe a mild and convenient method for modification of 1-ethynyl-4-hydroxyanthraquinone that was obtained from the Sonogashira reaction of 1-hydroxy-4-iodoanthraquinone with alkynes. The copper(I) catalyzed one-pot three component reaction (A3-coupling) of the new 1-ethynyl-4-hydroxyanthraquinone with secondary amines and formaldehyde was the main approach for the synthesis of nitrogen substituted 1-[3-(amino)prop-1-ynyl]-4-hydroxyanthraquinones. The influence of different substituent in the amine on reaction rate and yield has been evaluated. The cytotoxicity of 1-ethynyl-4-hydroxyanthraquinones was evaluated using the conventional MTT assay. Among all the compounds synthesized, anthraquinone-propargylamine derivatives 28, 29, 30 and 34 possess most promising cytotoxic potential towards glioblastoma cancer cells; compounds 14 and 19 shown selectivity towards the prostate cancer cells DU-145, and 18, and 24 – towards breast cancer cells MCF-7. The grown inhibition on these cancer cells of 18 and 24 was comparable to those of standard drug Doxorubicin. Molecular modeling of new compounds in DNA G-quadruplex binding site was performed to help understand the observed SAR trends.

A high yield one-pot aqueous synthesis of crystalline SnO2 nanoparticles

2017 ◽  
Vol 187 ◽  
pp. 151-153 ◽  
Author(s):  
R. Dujardin ◽  
F. Delorme ◽  
B. Pintault ◽  
P. Belleville ◽  
C. Autret ◽  
...  
Keyword(s):  
Sno2 Nanoparticles ◽  
High Yield ◽  
One Pot ◽  
Aqueous Synthesis
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