Catalyst-free one-pot domino reactions for selective synthesis of functionalized 2,8-oxazabicyclo[3.3.1]-nonanes and 5H-indeno[1,2-b]pyridin-5-ones

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64551-64558 ◽  
Author(s):  
Yin Rao ◽  
Meilin Liu ◽  
Lu Wu ◽  
Guodong Yin
Keyword(s):  
Efficient Method ◽  
Selective Synthesis ◽  
Domino Reactions ◽  
One Pot ◽  
Catalyst Free

A simple and efficient method for one-pot selective synthesis of functionalized 2,8-oxazaxabicyclo[3.3.1]nonanes and hydroxy-containing 5H-indeno[1,2-b]pyridin-5-ones under catalyst-free conditions has been developed.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Convenient and efficient synthesis of disubstituted piperazine derivatives by catalyst-free, atom-economical and tricomponent domino reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10768-10772 ◽  
Author(s):  
Hong-Ru Dong ◽  
Zi-Bao Chen ◽  
Rong-Shan Li ◽  
Heng-Shan Dong ◽  
Zhi-Xiang Xie
Keyword(s):  
Free Atom ◽  
Domino Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Piperazine Derivatives ◽  
High Yields

One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields.

scholarly journals Highly selective synthesis of 2,5-bis(aminomethyl)furan via catalytic amination of 5-(hydroxymethyl)furfural with NH3 over a bifunctional catalyst

RSC Advances ◽  
2019 ◽  
Vol 9 (66) ◽  
pp. 38877-38881 ◽  
Author(s):  
Hangkong Yuan ◽  
Bright T. Kusema ◽  
Zhen Yan ◽  
Stéphane Streiff ◽  
Feng Shi
Keyword(s):  
Efficient Method ◽  
Bifunctional Catalyst ◽  
Reaction Process ◽  
Selective Synthesis ◽  
Two Stage ◽  
One Pot ◽  
Hydroxymethyl Furfural ◽  
Highly Efficient ◽  
Catalytic Amination

A simple and highly efficient method was developed for one pot transformation of 5-(hydroxymethyl)furfural (5-HMF) into 2,5-bis(aminomethyl)furan (BAF) over bifunctional Cu4Ni1Al4Ox catalyst using two-stage reaction process, affording the BAF in 85.9% yield.

Synthesis of new chiral N-alkyl Betti-base ligands via one-pot three component strategy

2021 ◽  
Vol 10 ◽  
Author(s):  
Siva Ganesh ◽  
Kondabatini Sarika ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Asymmetric Reactions ◽  
Chiral Ligands ◽  
Chiral Auxiliaries ◽  
Chromatographic Purification ◽  
One Pot ◽  
Asymmetric Transformations ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Betti Base

Background: Betti base derivatives were employed as chiral ligands or as chiral auxiliaries in asymmetric transformations. In particular, N-alkyl Betti base derivatives are gaining importance as excellent ligands in asymmetric reactions. However there is no appropriate method exists for regioselective N-alkylation of Betti base. Therefore there is an urgent need to develop a new protocol for the regioselective N-alkylation of chiral Betti-base. Methods: An efficient method has been developed for one-pot synthesis of chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles under catalyst free conditions. Results: The chiral N-alkyl Betti-base ligands were obtained in good yields with excellent enantioselectivities. This method is a rapid, clean and does not require catalyst and chromatographic purification. Conclusion: We have developed an efficient one-pot three component strategy for the synthesis of new chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles in the absence of catalyst.

Catalyst-Free Synthesis of 1,4-Dihydroquinolines and Pyrrolo[1,2-a]quinolines via Intermolecular [4+2]/[3+2] Radical Cyclization of N-Methylanilines with Alkynoates

Synthesis ◽  
2020 ◽  
Vol 52 (07) ◽  
pp. 1067-1075
Author(s):  
Zaigang Luo ◽  
Xinxin Han ◽  
Chenfu Liu ◽  
Qiannan Liu ◽  
Rui Li ◽  
...  
Keyword(s):  
Efficient Method ◽  
Radical Cyclization ◽  
One Pot ◽  
Catalyst Free

Intermolecular [4+2]/[3+2] radical annulation of N-methyl­anilines with alkynoates under metal- and photoredox-catalyst-free conditions provides a practical and efficient method to synthesize bioactive 1,4-dihydroquinolines and pyrrolo[1,2-a]quinolines in one pot in moderate to high overall yields.

ChemInform Abstract: Catalyst-Free One-Pot Four-Component Domino Reactions in Water-PEG-400: Highly Efficient and Convergent Approach to Thiazoloquinoline Scaffolds.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
Anugula Nagaraju ◽  
B. Janaki Ramulu ◽  
Gaurav Shukla ◽  
Abhijeet Srivastava ◽  
Girijesh Kumar Verma ◽  
...  
Keyword(s):  
Domino Reactions ◽  
One Pot ◽  
Peg 400 ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Convergent Approach

An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis–Hillman reaction

2017 ◽  
Vol 41 (17) ◽  
pp. 9203-9209 ◽  
Author(s):  
Thatikonda Narendar Reddy ◽  
Bikshapathi Raktani ◽  
Ramesh Perla ◽  
Mettu Ravinder ◽  
Jayathirtha Rao Vaidya ◽  
...  
Keyword(s):  
Efficient Method ◽  
One Pot ◽  
Efficient Catalyst ◽  
Free Condition ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Methanol System

Herein, a facile and efficient method for the preparation of allyl amides from the aldehydes of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition.

Catalyst-free one-pot four-component domino reactions in water–PEG-400: highly efficient and convergent approach to thiazoloquinoline scaffolds

2015 ◽  
Vol 17 (2) ◽  
pp. 950-958 ◽  
Author(s):  
Anugula Nagaraju ◽  
B. Janaki Ramulu ◽  
Gaurav Shukla ◽  
Abhijeet Srivastava ◽  
Girijesh Kumar Verma ◽  
...  
Keyword(s):  
Domino Reactions ◽  
One Pot ◽  
Peg 400 ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Convergent Approach

Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds is achievedviafour-component domino reactions in water–PEG.

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