Catalyst-free one-pot sustainable synthesis of thiazoloquinoline and thiazolopyridine scaffolds is achievedviafour-component domino reactions in water–PEG.
One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields.
A green, efficient, multi-component protocol has been developed for synthesis of novel bis-spirooxindoles in short reaction time, easy workup and excellent yields.
A simple and safe one-pot four component synthesis of Kabachnik–Fields synthesis of novel α-amino phosphonates under solvent-free and catalyst-free conditions is reported.
Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent