Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery

2013 ◽  
Vol 49 (93) ◽  
pp. 10938 ◽  
Author(s):  
Li Yan ◽  
Wei Chen ◽  
Xiaoyue Zhu ◽  
Longbiao Huang ◽  
Zhigang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Layered Double Hydroxide ◽  
Targeted Drug Delivery ◽  
High Efficacy ◽  
Targeted Drug ◽  
Self Assembled ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Antibody-Targeted Drug Delivery to Injured Arteries Using Layered Double Hydroxide Nanoparticles

2012 ◽  
Vol 1 (5) ◽  
pp. 669-673 ◽  
Author(s):  
Zi Gu ◽  
Barbara E. Rolfe ◽  
Zhi Ping Xu ◽  
Julie H. Campbell ◽  
G. Q. Max Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Layered Double Hydroxide ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Layered double hydroxide modified by PEGylated hyaluronic acid as a hybrid nanocarrier for targeted drug delivery

2016 ◽  
Vol 22 (3) ◽  
pp. 237-246 ◽  
Author(s):  
Anjie Dong ◽  
Xue Li ◽  
Weiwei Wang ◽  
Shangcong Han ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Layered Double Hydroxide ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Double Hydroxide

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

A novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13673-13683 ◽  
Author(s):  
Luyao Wang ◽  
Mengke Qu ◽  
Shiqi Huang ◽  
Yu Fu ◽  
Liuqing Yang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
High Efficacy ◽  
Prostate Cancer Therapy ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

The current work has designed a novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy using the pHCT74 peptide.

Aptamer-based self-assembled supramolecular vesicles for pH-responsive targeted drug delivery

2016 ◽  
Vol 60 (5) ◽  
pp. 628-634 ◽  
Author(s):  
Shuxian Wu ◽  
Juan Li ◽  
Hong Liang ◽  
Liping Wang ◽  
Xian Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Targeted Drug ◽  
Self Assembled
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