Effect of glucose tolerance factor (GTF) from high chromium yeast on glucose metabolism in insulin-resistant 3T3-L1 adipocytes

RSC Advances ◽  
2015 ◽  
Vol 5 (5) ◽  
pp. 3482-3490 ◽  
Author(s):  
L. Liu ◽  
W. M. Cui ◽  
S. W. Zhang ◽  
F. H. Kong ◽  
M. A. Pedersen ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Tolerance Factor ◽  
High Chromium ◽  
Relative Expression ◽  
Insulin Resistant ◽  
Chromium Yeast ◽  
Effect Of Glucose ◽  
Glucose Tolerance Factor

Relative expression of IR, IRS-1, IRS-2 and GLUT4 mRNA was determined in insulin-resistant 3T3-L1 adipocytes with different treatments.

Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly

2018 ◽  
Vol 50 (05) ◽  
pp. 408-413 ◽  
Author(s):  
Sema Dogansen ◽  
Gulsah Yalin ◽  
Seher Tanrikulu ◽  
Sema Yarman
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Glucose Metabolism Disorders ◽  
Insulin Resistant ◽  
Normal Glucose ◽  
Resistant Group ◽  
The Impact

AbstractIn this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38, 41%), and diabetes mellitus (n=32, 34%). Insulin resistance was calculated with homeostasis model assessment (HOMA). HOMA-IR > 2.5 or ≤2.5 were defined as insulin resistant or noninsulin resistant groups, respectively. Groups were compared in terms of factors that may be associated with glucose metabolism abnormalities. IGF-1% ULN (upper limit of normal)/GH ratios were used to evaluate the impact of glucose metabolism abnormalities on IGF-1 levels. Patients with diabetes mellitus were significantly older with an increased frequency of hypertension (p<0.001, p=0.01, respectively). IGF-1% ULN/GH ratio was significantly lower in prediabetes group than in normal glucose tolerance group (p=0.04). Similarly IGF-1% ULN/GH ratio was significantly lower in insulin resistant group than in noninsulin resistant group (p=0.04). Baseline and suppressed GH levels were significantly higher in insulin resistant group than in noninsulin resistant group (p=0.024, p<0.001, respectively). IGF-1% ULN/GH ratio is a useful marker indicating glucose metabolism disorders and IGF-1 levels might be inappropriately lower in acromegalic patients with insulin resistance or prediabetes. We suggest that IGF-1 levels should be re-evaluated after the improvement of insulin resistance or glycemic regulation for the successful management of patients with acromegaly.

Relation of glucose tolerance factor to impaired intravenous glucose tolerance of rats on stock diets

1959 ◽  
Vol 196 (3) ◽  
pp. 614-618 ◽  
Author(s):  
Walter Mertz ◽  
Klaus Schwarz
Keyword(s):  
Glucose Tolerance ◽  
Water Soluble ◽  
Tolerance Factor ◽  
Brewer’S Yeast ◽  
Removal Rates ◽  
Intravenous Glucose ◽  
Brewer's Yeast ◽  
Intravenous Glucose Tolerance ◽  
Low Glucose ◽  
Glucose Tolerance Factor

Intravenous glucose tolerance tests were made on male Sprague-Dawley rats, raised on different diets. Two natural diets (McCollum's wheat-casein ration and table scraps) produced glucose removal rates of around 4%/min. or more. In rats raised on three commercial pelleted stock rations (Purina, Hunt Club, Rockland) as well as on a semipurified Torula yeast diet, low glucose removal rates of 2.5–2.8%/min. were consistently detected after 20 or more days of feeding. The results are related to the contents, in the investigated diets, of the glucose tolerance factor (GTF), a recently described, water soluble dietary agent of low molecular weight. Development of low glucose removal rates is prevented by dietary supplementation with brewer's yeast, or with GTF concentrates from brewer's yeast or pork kidney powder. The fully developed impairment is cured within 1–2 weeks by the addition of GTF concentrates to the diet. It is also reconstituted to normal within 18 hours after stomach tubing of GTF fractions of widely different degrees of purification. This curative procedure is being used as a 24-hour test for GTF.

ChemInform Abstract: CHROMIUM(III) AND THE GLUCOSE TOLERANCE FACTOR

1985 ◽  
Vol 16 (31) ◽  
Author(s):  
J. BARRETT ◽  
P. O'BRIEN ◽  
J. D. PEDROSA DE JESUS
Keyword(s):  
Glucose Tolerance ◽  
Tolerance Factor ◽  
Glucose Tolerance Factor

Synthetic models for the glucose tolerance factor: the spectroscopic characterization and toxicity studies of monomeric and dimeric Cr(III) species

Polyhedron ◽  
1998 ◽  
Vol 17 (21) ◽  
pp. 3785-3794 ◽  
Author(s):  
Gabriela Galuszka ◽  
Maria Cieslak-Golonka ◽  
Adam Szelag ◽  
Jan Starosta ◽  
Agnieszka Wojciechowska
Keyword(s):  
Glucose Tolerance ◽  
Spectroscopic Characterization ◽  
Tolerance Factor ◽  
Toxicity Studies ◽  
Glucose Tolerance Factor ◽  
Synthetic Models
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