Zinc, copper and nickel derivatives of 2-[2-bromoethyliminomethyl]phenol as topoisomerase inhibitors exhibiting anti-proliferative and anti-metastatic properties

RSC Advances ◽  
2014 ◽  
Vol 4 (104) ◽  
pp. 60280-60292 ◽  
Author(s):  
Sze Koon Lee ◽  
Kong Wai Tan ◽  
Seik Weng Ng
Keyword(s):  
Transition Metal ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Calf Thymus Dna ◽  
Topoisomerase Inhibitors ◽  
Calf Thymus ◽  
Derivatives Of

Transition metal (Zn, Cu and Ni) derivatives of (2-[2-bromoethyliminomethyl]phenol), were found to inhibit topoisomerase I activity, induce DNA cleavage and bind to calf thymus DNA. The compounds are also cytotoxic and anti-invasive against PC3.

Interactions of new derivatives of anthracene with calf thymus DNA

2002 ◽  
Author(s):  
Marian Wolszczak ◽  
Edyta Grzesiak ◽  
Dorota Kowalczyk ◽  
Ryszard Ostaszewski
Keyword(s):  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Derivatives Of

DNA Cleavage by Topoisomerase I in the Presence of Indolocarbazole Derivatives of Rebeccamycin†

Biochemistry ◽  
1997 ◽  
Vol 36 (13) ◽  
pp. 3917-3929 ◽  
Author(s):  
Christian Bailly ◽  
Jean-François Riou ◽  
Pierre Colson ◽  
Claude Houssier ◽  
Elisabète Rodrigues-Pereira ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Topoisomerase I ◽  
Derivatives Of

Study of binding of some amino acid derivatives of 2,2'-bipyridineplatinun(ii) to calf thymus dna

1986 ◽  
Vol 27 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Renu Mitai ◽  
K. Sen Ray ◽  
T.S. Srivastava ◽  
R.K. Bhattacharya
Keyword(s):  
Amino Acid ◽  
Calf Thymus Dna ◽  
Amino Acid Derivatives ◽  
Calf Thymus ◽  
Derivatives Of
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