Antitumor efficacy of a PLGA composite nanofiber embedded with doxorubicin@MSNs and hydroxycamptothecin@HANPs

RSC Advances ◽  
2014 ◽  
Vol 4 (95) ◽  
pp. 53344-53351 ◽  
Author(s):  
Mengxia Chen ◽  
Wei Feng ◽  
Si Lin ◽  
Chuanglong He ◽  
Yu Gao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Antitumor Efficacy ◽  
Composite Nanofiber

A co-delivery system with two or more anticancer drugs has been proposed to minimize the dosage of drug and to achieve the synergistic therapeutic effect in cancer therapy.

Development of a redox/pH dual stimuli-responsive MSP@P(MAA-Cy) drug delivery system for programmed release of anticancer drugs in tumour cells

2014 ◽  
Vol 2 (32) ◽  
pp. 5187-5194 ◽  
Author(s):  
Dian Li ◽  
Yuting Zhang ◽  
Sha Jin ◽  
Jia Guo ◽  
Haifeng Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Tumour Cells ◽  
Stimuli Responsive ◽  
Programmed Release

A redox/pH dual-stimuli-responsive drug delivery system for programmed release of anticancer drugs has been developed for enhancing the therapeutic effect.

Unimolecular micelles of pH-responsive star-like copolymers for co-delivery of anticancer drugs and small-molecular photothermal agents: a new drug-carrier for combinational chemo/photothermal cancer therapy

2017 ◽  
Vol 5 (43) ◽  
pp. 8514-8524 ◽  
Author(s):  
Tao Jia ◽  
Shuo Huang ◽  
Cangjie Yang ◽  
Mingfeng Wang
Keyword(s):  
Cancer Therapy ◽  
Cancer Cells ◽  
Therapeutic Effect ◽  
Anticancer Drugs ◽  
Drug Carrier ◽  
Ph Responsive ◽  
New Drug

Robust unimolecular micelles of amphiphilic pH-responsive starlike copolymers that carry anticancer drugs and photothermal agents show enhanced therapeutic effect against cancer cells.

Thermosensitive heparin-Pluronic® copolymer as effective dual anticancer drugs delivery system for combination cancer therapy

2018 ◽  
Vol 15 (1/2/3) ◽  
pp. 174 ◽  
Author(s):  
Nhat Anh N. Tong ◽  
Ngoc Quyen Tran ◽  
Xuan Thi Diem Trinh Nguyen ◽  
Van Du Cao ◽  
Thi Phuong Nguyen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Combination Cancer Therapy

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer

2021 ◽  
Author(s):  
Mei Jiang ◽  
Yuchen Lin ◽  
Xiaocui Fang ◽  
Mingpeng Liu ◽  
Lilusi Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Delivery System ◽  
Gold Nanoclusters ◽  
Cationic Peptide ◽  
Gold Nanocluster ◽  
Lung Cancer Therapy ◽  
Anti Tumor Activity

A novel delivery system for cisplatin based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide was constructed. The constructed cisplatin@GC-pKs showed much enhanced anti-tumor activity for lung cancer therapy.

scholarly journals Bioinformatic Analysis of the Nicotinamide Binding Site in Poly(ADP-Ribose) Polymerase Family Proteins

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1201
Author(s):  
Garri Manasaryan ◽  
Dmitry Suplatov ◽  
Sergey Pushkarev ◽  
Viktor Drobot ◽  
Alexander Kuimov ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Binding Site ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Bioinformatic Analysis ◽  
Parp Inhibitors ◽  
Functional Region ◽  
D Loop

The PARP family consists of 17 members with diverse functions, including those related to cancer cells’ viability. Several PARP inhibitors are of great interest as innovative anticancer drugs, but they have low selectivity towards distinct PARP family members and exert serious adverse effects. We describe a family-wide study of the nicotinamide (NA) binding site, an important functional region in the PARP structure, using comparative bioinformatic analysis and molecular modeling. Mutations in the NA site and D-loop mobility around the NA site were identified as factors that can guide the design of selective PARP inhibitors. Our findings are of particular importance for the development of novel tankyrase (PARPs 5a and 5b) inhibitors for cancer therapy.

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