Construction of micelles based on biocompatible pseudo-graft polymers via β-cyclodextrin/cholesterol interaction for protein delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (77) ◽  
pp. 40882-40891 ◽  
Author(s):  
Hui Han ◽  
De-E Liu ◽  
Hongguang Lu ◽  
Wen-Xing Gu ◽  
Hui Gao
Keyword(s):  
Aspartic Acid ◽  
Graft Copolymer ◽  
Self Assembly ◽  
Protein Delivery ◽  
Inclusion Complexation ◽  
The Self ◽  
Graft Polymers ◽  
Copolymer Micelle

A pseudo-graft copolymer micelle was constructed from the self-assembly of (6-(2-aminoethyl)-amino-6-deoxy)-cyclodextrin (β-CDen)-modified poly(aspartic acid) (PASP-CD) with cholesterol-modified poly(d,l-lactide) (PLA-Chol) using host–guest inclusion complexation in water.

scholarly journals Janus or homogeneous nanoparticle mediated self-assembly of polymer electrolyte fuel cell membranes

RSC Advances ◽  
2018 ◽  
Vol 8 (33) ◽  
pp. 18568-18575 ◽  
Author(s):  
Yusei Kobayashi ◽  
Noriyoshi Arai
Keyword(s):  
Fuel Cell ◽  
Polymer Electrolyte ◽  
Self Assembly ◽  
Cell Membranes ◽  
Chemical Nature ◽  
The Self ◽  
Polymer Electrolyte Fuel Cell ◽  
Fuel Cell Membranes ◽  
Graft Polymers

We investigated the effect of the chemical nature of nanoparticles for the self-assembly of graft polymers. Hydrophilic nanoparticles had the largest effect in suppressing the diffusion of water because it is incorporated into the water particles.

Self-Assembly of Amphiphilic Graft Copolymer with Poly(acrylic Acid) Backbone and N-Octylphenyl Poly(oxyethylene) Side Chains in Water

2011 ◽  
Vol 233-235 ◽  
pp. 2138-2144 ◽  
Author(s):  
Fang Ping Wang ◽  
Xin Zhen Du ◽  
Hu Po Mu ◽  
Dong Xia Zhang ◽  
Yun Jun Ma
Keyword(s):  
Electron Microscopy ◽  
Graft Copolymer ◽  
Self Assembly ◽  
Inorganic Salt ◽  
The Self ◽  
Fluorescence Technique ◽  
Preparation Methods ◽  
Amphiphilic Graft Copolymer ◽  
Ph Values ◽  
Transmission Electron

The self-assembly of the amphiphilic graft copolymer AA-C8PhEO10Ac in water was investigated by fluorescence technique using 8-anilino-1-naphthalene sulfonate(ANS) as a probe and transmission electron microscopy (TEM), the effects of inorganic salt , copolymer concentration and pH on the micellar size and structures of AA-C8PhEO10Ac were discussed. It was found that the micelle morphologies and sizes were related with the micellar preparation methods. The sizes of micelles increased with the addition of NaCl and decreased at high pH values.

Synthesis and self-assembly of well-defined binary graft copolymer and its use in superhydrophobic cotton fabrics preparation

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46132-46145 ◽  
Author(s):  
Yinwen Li ◽  
Xiuwen Zheng ◽  
Huayu Zhu ◽  
Kun Wu ◽  
Mangeng Lu
Keyword(s):  
Graft Copolymer ◽  
Self Assembly ◽  
Cotton Fabrics ◽  
The Self

Schematic illustrations of the self-assembly of BGCs and photographs of superhydrophobic performance.

Synthesis and self-assembly of a dual thermal and pH-responsive ternary graft copolymer for sustained release drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2571-2581 ◽  
Author(s):  
Yinwen Li ◽  
Xiuwen Zheng ◽  
Kun Wu ◽  
Mangeng Lu
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Graft Copolymer ◽  
Self Assembly ◽  
The Self ◽  
Release Mechanism ◽  
Ph Responsive ◽  
Release Drug

Schematic illustrations of the self-assembly of TGCs and possible loading and release mechanism.

The Nature of Rapidly Extracted Phycocyanin from the Blue-Green Alga Plectonema Boryanum

1971 ◽  
Vol 29 ◽  
pp. 366-367
Author(s):  
M. Kessel ◽  
R. MacColl
Keyword(s):  
Self Assembly ◽  
Analytical Ultracentrifugation ◽  
Uranyl Acetate ◽  
The Self ◽  
Major Protein ◽  
Subunit Structure ◽  
Blue Green Alga ◽  
Thin Sections ◽  
Blue Green Algae ◽  
Cacodylate Buffer

The major protein of the blue-green algae is the biliprotein, C-phycocyanin (Amax = 620 nm), which is presumed to exist in the cell in the form of distinct aggregates called phycobilisomes. The self-assembly of C-phycocyanin from monomer to hexamer has been extensively studied, but the proposed next step in the assembly of a phycobilisome, the formation of 19s subunits, is completely unknown. We have used electron microscopy and analytical ultracentrifugation in combination with a method for rapid and gentle extraction of phycocyanin to study its subunit structure and assembly.To establish the existence of phycobilisomes, cells of P. boryanum in the log phase of growth, growing at a light intensity of 200 foot candles, were fixed in 2% glutaraldehyde in 0.1M cacodylate buffer, pH 7.0, for 3 hours at 4°C. The cells were post-fixed in 1% OsO4 in the same buffer overnight. Material was stained for 1 hour in uranyl acetate (1%), dehydrated and embedded in araldite and examined in thin sections.

Interrelationship of the cellular distribution and secretion of regular structure (RS) protein in Bacillus licheniformis nm 105

1992 ◽  
Vol 50 (1) ◽  
pp. 712-713
Author(s):  
Xiaorong Zhu ◽  
Richard McVeigh ◽  
Bijan K. Ghosh
Keyword(s):  
Alkaline Phosphatase ◽  
Bacillus Licheniformis ◽  
Self Assembly ◽  
Gel Electrophoresis ◽  
Culture Supernatant ◽  
Regular Structure ◽  
The Self ◽  
Cellular Distribution ◽  
Structural Protein ◽  
Laboratory Cultures

A mutant of Bacillus licheniformis 749/C, NM 105 exhibits some notable properties, e.g., arrest of alkaline phosphatase secretion and overexpression and hypersecretion of RS protein. Although RS is known to be widely distributed in many microbes, it is rarely found, with a few exceptions, in laboratory cultures of microorganisms. RS protein is a structural protein and has the unusual properties to form aggregate. This characteristic may have been responsible for the self assembly of RS into regular tetragonal structures. Another uncommon characteristic of RS is that enhanced synthesis and secretion which occurs when the cells cease to grow. Assembled RS protein with a tetragonal structure is not seen inside cells at any stage of cell growth including cells in the stationary phase of growth. Gel electrophoresis of the culture supernatant shows a very large amount of RS protein in the stationary culture of the B. licheniformis. It seems, Therefore, that the RS protein is cotranslationally secreted and self assembled on the envelope surface.

Nanoscale Self-Assembly Using Ion and Electron Beam Techniques: A Rapid Review

MRS Advances ◽  
2020 ◽  
Vol 5 (64) ◽  
pp. 3507-3520
Author(s):  
Chunhui Dai ◽  
Kriti Agarwal ◽  
Jeong-Hyun Cho
Keyword(s):  
Electron Beam ◽  
Self Assembly ◽  
Ion Beam ◽  
Three Dimensional ◽  
The Self ◽  
Stress Generation ◽  
Rapid Review ◽  
High Yield ◽  
3D Nanostructures ◽  
Self Assembled

AbstractNanoscale self-assembly, as a technique to transform two-dimensional (2D) planar patterns into three-dimensional (3D) nanoscale architectures, has achieved tremendous success in the past decade. However, an assembly process at nanoscale is easily affected by small unavoidable variations in sample conditions and reaction environment, resulting in a low yield. Recently, in-situ monitored self-assembly based on ion and electron irradiation has stood out as a promising candidate to overcome this limitation. The usage of ion and electron beam allows stress generation and real-time observation simultaneously, which significantly enhances the controllability of self-assembly. This enables the realization of various complex 3D nanostructures with a high yield. The additional dimension of the self-assembled 3D nanostructures opens the possibility to explore novel properties that cannot be demonstrated in 2D planar patterns. Here, we present a rapid review on the recent achievements and challenges in nanoscale self-assembly using electron and ion beam techniques, followed by a discussion of the novel optical properties achieved in the self-assembled 3D nanostructures.

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

Bottom-up Evolution from Disks to High-Genus Polymersomes

2018 ◽  
Author(s):  
Claudia Contini ◽  
Russell Pearson ◽  
Linge Wang ◽  
Lea Messager ◽  
Jens Gaitzsch ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Copolymers ◽  
Chain Entanglement ◽  
Bottom Up ◽  
New Approach ◽  
High Genus ◽  
Transmission Electron ◽  
Minimal Radius ◽  
Stop Flow

<div><div><div><p>We report the design of polymersomes using a bottom-up approach where the self-assembly of amphiphilic copolymers poly(2-(methacryloyloxy) ethyl phosphorylcholine)–poly(2-(diisopropylamino) ethyl methacrylate) (PMPC-PDPA) into membranes is tuned using pH and temperature. We study this process in detail using transmission electron microscopy (TEM), nuclear magnetic resonance (NMR) spectroscopy, dynamic light scattering (DLS), and stop-flow ab- sorbance disclosing the molecular and supramolecular anatomy of each structure observed. We report a clear evolution from disk micelles to vesicle to high-genus vesicles where each passage is controlled by pH switch or temperature. We show that the process can be rationalised adapting membrane physics theories disclosing important scaling principles that allow the estimation of the vesiculation minimal radius as well as chain entanglement and coupling. This allows us to propose a new approach to generate nanoscale vesicles with genus from 0 to 70 which have been very elusive and difficult to control so far.</p></div></div></div>

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