Synthesis and self-assembly of a dual thermal and pH-responsive ternary graft copolymer for sustained release drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 2571-2581 ◽  
Author(s):  
Yinwen Li ◽  
Xiuwen Zheng ◽  
Kun Wu ◽  
Mangeng Lu
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Graft Copolymer ◽  
Self Assembly ◽  
The Self ◽  
Release Mechanism ◽  
Ph Responsive ◽  
Release Drug

Schematic illustrations of the self-assembly of TGCs and possible loading and release mechanism.

pH-responsive and sustained release drug delivery system of BSA coated CDs-DOX

2021 ◽  
pp. 131358
Author(s):  
Qianqian Duan ◽  
Jiaying Shi ◽  
Lan Zhou ◽  
Boye Zhang ◽  
Xiaoyuan Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Responsive ◽  
Release Drug

Doxorubicin-reinforced supramolecular hydrogels of RGD-derived peptide conjugates for pH-responsive drug delivery

2019 ◽  
Vol 17 (15) ◽  
pp. 3853-3860 ◽  
Author(s):  
Leixia Mei ◽  
Keming Xu ◽  
Ziran Zhai ◽  
Suyun He ◽  
Tingting Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
The Self ◽  
Ph Responsive ◽  
Peptide Conjugates

Doxorubicin reinforced the self-assembly of RGD-derived peptide conjugates responsive to mild acidity.

Octreotide-mediated tumor cell uptake and intracellular pH-responsive drug delivery of the self-assembly supramolecular nanocarrier

2013 ◽  
Vol 21 (5) ◽  
pp. 415-426 ◽  
Author(s):  
Jiangxiu Niu ◽  
Aiwen Huang ◽  
Yanyu Xiao ◽  
Zhigui Su ◽  
Hongying Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cell ◽  
Intracellular Ph ◽  
Self Assembly ◽  
The Self ◽  
Cell Uptake ◽  
Ph Responsive

Formulation Optimization of Sustained Release Resinate Microcapsules of Tramadol Hydrochloride by Using 3/2 Factorial Design

2017 ◽  
Vol 6 (2) ◽  
pp. 57
Author(s):  
Kamble Ravindra K. ◽  
Chauhan Chetan S. ◽  
Kamble Priyadarshani R. ◽  
Naruka Pushpendra S.
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Sustained Release ◽  
Factorial Design ◽  
Linear Regression Analysis ◽  
Extended Period ◽  
Multiple Linear Regression Analysis ◽  
Water Soluble ◽  
Tramadol Hydrochloride ◽  
Release Drug

The main aim of the present work was to develop the microcapsules of tramadol hydrochloride for the oral sustained release drug delivery. Tramadol hydrochloride a BCS class I drug a centrally acting synthetic analgesic was complexed with Indion 254 ion exchange resin. The microcapsules were prepared by encapsulating the prepared resinates by o/o solvent evaporation technique. In the investigation 32 full factorial design was used to investigate the joint influence of two formulation variable amount of eudragit RS 100 and plasticized PEG 400. The results of multiple linear regression analysis indicated that for obtaining a sustained release drug delivery the optimum concentrations of both the plasticizer and coating solution to be used. The factorial models were used to prepare optimized microcapsules and optimized formulations showed sustained release profiles for the extended period of more than 12 hrs. From the present investigations concluded that resinate microcapsules of highly water soluble drug can provide controlled release of drug for extended period.Key Words: Tramadol hydrochloride, ion exchange resinate, microcapsules, sustained release

Synthesis of PMMA-b-PS Block Copolymer by Emulsion ATRP and its Self-Assembly Property

2013 ◽  
Vol 705 ◽  
pp. 115-119
Author(s):  
Bao Yong Tian ◽  
Er Jun Tang ◽  
Miao Yuan ◽  
Rui Xia Hao ◽  
Cun Man Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Potential Application ◽  
Morphological Characteristic ◽  
Living Polymerization ◽  
The Self ◽  
Emulsion System ◽  
Copolymer Concentration ◽  
Ft Ir

The well-defined block copolymer PMMA-b-PS was prepared by two-step ATRP in emulsion system. GPC results indicate that Mn increased linearly with conversion and polydispersity remained relatively narrow. It presents the characteristics of living polymerization in emulsion system. FT-IR demonstrated that block copolymer PMMA-b-PS could be successfully synthesized by ATRP with macroinitiator PMMA-Cl in emulsion system. The morphological characteristic of the self-assembly depends on the block copolymer concentration and transforms between spheres and rodlike micelles. The property indicates a perfect potential application in drug delivery materials.

scholarly journals Recent advances in intraocular sustained-release drug delivery devices

2019 ◽  
Vol 24 (8) ◽  
pp. 1694-1700 ◽  
Author(s):  
Yiqi Cao ◽  
Karen E. Samy ◽  
Daniel A. Bernards ◽  
Tejal A. Desai
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Drug ◽  
Recent Advances ◽  
Drug Delivery Devices
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