scholarly journals Novel thermosensitive telechelic PEGs with antioxidant activity: synthesis, molecular properties and conformational behaviour

RSC Advances ◽  
2014 ◽  
Vol 4 (79) ◽  
pp. 41763-41771 ◽  
Author(s):  
Olga Sergeeva ◽  
Petr S. Vlasov ◽  
Nina S. Domnina ◽  
Anna Bogomolova ◽  
Petr V. Konarev ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biomedical Applications ◽  
Molecular Properties ◽  
Polymer Conjugates

We report on the tailor-made polymer conjugates, which are highly compelling for biomedical applications due to their antioxidant activity and the adjustable thermosensitive properties.

Copper complexes for biomedical applications: Structural insights, antioxidant activity and neuron compatibility

2019 ◽  
Vol 192 ◽  
pp. 87-97 ◽  
Author(s):  
Ladan Esmaeili ◽  
Mariela Gomez Perez ◽  
Maziar Jafari ◽  
Joanne Paquin ◽  
Pompilia Ispas-Szabo ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Biomedical Applications ◽  
Copper Complexes ◽  
Structural Insights

The antioxidant activity of conducting polymers in biomedical applications

2004 ◽  
Vol 4 (2-4) ◽  
pp. 347-350 ◽  
Author(s):  
Marija Gizdavic-Nikolaidis ◽  
Jadranka Travas-Sejdic ◽  
Graham A. Bowmaker ◽  
Ralph P. Cooney ◽  
Corrina Thompson ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Conducting Polymers ◽  
Biomedical Applications

scholarly journals Functionalization and antioxidant activity of polyaniline–fullerene hybrid nanomaterials: a theoretical investigation

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14595-14605 ◽  
Author(s):  
Nguyen Minh Thong ◽  
Quan V. Vo ◽  
Trinh Le Huyen ◽  
Mai Van Bay ◽  
Nguyen Nho Dung ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Theoretical Investigation ◽  
Biomedical Applications ◽  
Hybrid Nanomaterials ◽  
Novel Materials

Functionalized fullerene is one of the most advantageous nanotechnologies to develop novel materials for potential biomedical applications.

Phosphorus-containing star-shaped polymer conjugates for biomedical applications

2021 ◽  
Vol 142 ◽  
pp. 110151
Author(s):  
Zornica Todorova ◽  
Oyundari Tumurbaatar ◽  
Jordana Todorova ◽  
Iva Ugrinova ◽  
Neli Koseva
Keyword(s):  
Biomedical Applications ◽  
Polymer Conjugates ◽  
Phosphorus Containing ◽  
Star Shaped Polymer

scholarly journals STUDIES ON THE ANTIOXIDANT ACTIVITY OF APIGENIN, LUTEOLIN AND NEVADENSIN USING DFT

2021 ◽  
Vol 59 (1) ◽  
pp. 19
Author(s):  
Dung Trinh ◽  
Huy Trung ◽  
Xuyen Nguyen ◽  
Nguyễn Tráng ◽  
Hong Cao ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gas Phase ◽  
Dft Method ◽  
Molecular Properties ◽  
Flavonoid Compounds ◽  
Antioxidant Agent ◽  
Mechanism And Kinetics

The molecular properties of apigenin, luteolin and nevadensin which are three naturally flavonoid compounds have been studied theoretically by DFT method at 6-311++G(d,p) level. Both FMO analysis, mechanism, and kinetics studied suggested that compound Luteolin (compound 3) was a promising antioxidant agent. The results indicated that  HAT is thermodynamically preferred in the gas phase, and SPLET is the thermodynamically favorable pathway in methanol and water

Synthesis, Self-Assembly, and Biomedical Applications of Antimicrobial Peptide–Polymer Conjugates

2018 ◽  
Vol 19 (6) ◽  
pp. 1701-1720 ◽  
Author(s):  
Hui Sun ◽  
Yuanxiu Hong ◽  
Yuejing Xi ◽  
Yijie Zou ◽  
Jingyi Gao ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Polymer Conjugates

scholarly journals Design, Synthesis, andIn VitroAntioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
P. C. Jagadish ◽  
Neeraj Soni ◽  
Amita Verma
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Nmr Spectroscopy ◽  
Microwave Irradiation ◽  
Mass Spectroscopy ◽  
Mannich Base ◽  
Molecular Properties ◽  
Microwave Irradiation Method ◽  
Design Synthesis ◽  
Ir And Nmr Spectroscopy

Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration. The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”, and compound 3e havingp-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.

scholarly journals Structural analysis of DNA and RNA interactions with antioxidant flavonoids

2009 ◽  
Vol 23 (1) ◽  
pp. 29-43 ◽  
Author(s):  
C. D. Kanakis ◽  
Sh. Nafisi ◽  
Mehdi Rajabi ◽  
Azadeh Shadaloi ◽  
P. A. Tarantilis ◽  
...  
Keyword(s):  
Dna Damage ◽  
Antioxidant Activity ◽  
Structural Analysis ◽  
Biomedical Applications ◽  
Binding Constants ◽  
Physiological Conditions ◽  
Dna And Rna ◽  
Rna Duplexes ◽  
Antiviral Activities ◽  
The Stability

Flavonoids are natural polyphynolic compounds with major antioxidant activity that can prevent DNA damage. The anticancer and antiviral activities of these natural products are attributed to their potential biomedical applications. In this review we are examining how the antioxidant flavonoids bind DNA and RNA and what mechanism of action is involved in preventing DNA damage. Detailed spectroscopic data on the interactions of morin (mor), apigenin (api), naringin (nar), quercetin (que), kaempferol (kae) and delphinidin (del) with DNA and transfer RNA in aqueous solution at physiological conditions were analysed. The structural analysis showed flavonoids mainly intercalate into DNA and RNA duplexes with minor external binding to the major or minor groove and the backbone phosphate group with overall binding constants for DNA adducts Kmor═5.99×103M–1, Kapi═7.10×104M–1, and Knar═3.10×103M–1, Kque═7.25×104M–1, Kkae═3.60×104M–1and Kdel═1.66×104M–1, and for tRNA adducts Kmor═9.15×103M–1, Kapi═4.96×104M–1, and Knar═1.14×104M–1, Kque═4.80×104M–1, Kkae═4.65×104M–1and Kdel═9.47×104M–1. The stability of adduct formation is in the order of que > api > kae > del >mor > nar for DNA and del > api > que > kae > nar > mor for tRNA. Low flavonoid concentration induces helical stabilization, whereas high pigment content causes helix opening. Flavonoids induce a partial B to A–DNA transition at high pigment concentration, while tRNA remains in A-family structure upon flavonoid complexation. The antioxidant activity of flavonoids changes in the order delphinidin > quercetin > kaempferol > morin > naringin > apigenin. The results show intercalated flavonoid molecule can act as an antioxidant and prevent DNA damage.

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