Nanoparticle mediated organic synthesis (NAMO-synthesis): CuI-NP catalyzed ligand free amidation of aryl halides
Keyword(s):
One Pot
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We have demonstrated the first ligand free CuI-nanoparticle catalyzed N-arylation of amides/cyclic amides in an ethylene glycol/2-propanol solvent system under mild conditions. This is further extended for one pot synthesis of benzimidazole, and quinazolinone via intermolecular amidation followed by cyclization.