Biodegradable multiblock polyurethane micelles with tunable reduction-sensitivity for on-demand intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (47) ◽  
pp. 24736-24746 ◽  
Author(s):  
Xueling He ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages ◽  
Drug Delivery Applications

Biodegradable polyurethanes bearing varied amounts of disulfide linkages in the backbone can rapidly enter tumor cells and efficiently transport the encapsulated payloads into cytosol, resulting in controlled inhibition effects against cancer cells. The nanocarriers are promising candidates for on-demand intracellular drug delivery applications.

Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (109) ◽  
pp. 107337-107343 ◽  
Author(s):  
Iman Rostami ◽  
ZiJian Zhao ◽  
ZiHua Wang ◽  
WeiKai Zhang ◽  
Yeteng Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Targeting Peptide

Efficient drug delivery to the tumor cells was carried out with HER2 targeting peptide-conjugated PEGlyted PAMAM.

scholarly journals A doxorubicin–platinum conjugate system: impacts on PI3K/AKT actuation and apoptosis in breast cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 4818-4828
Author(s):  
Puja Patel ◽  
Devan Umapathy ◽  
Selvambigai Manivannan ◽  
Vinita Manimaran Nadar ◽  
Rajiu Venkatesan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Conjugate System ◽  
Drug Delivery Applications

In recent years, the development of a nano-conjugate system for drug delivery applications has gained attention among researchers.

scholarly journals Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activity

2020 ◽  
Author(s):  
Lei Wang ◽  
Xusha Zhou ◽  
Weixuan Zou ◽  
Yinglin Wu ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Growth Factor Receptor ◽  
Wide Range ◽  
Epidermal Growth

Abstract Background: Exosomes are small, cellular membrane-derived vesicles with a diameter of 50-150 nm. Exosomes are considered ideal drug delivery systems with a wide range of applications in various diseases, including cancer. However, nonspecific delivery of therapeutic agents by exosomes in vivo remains challenging. H uman epidermal growth factor receptor 2 (HER2) is an epidermal growth factor receptor tyrosine kinase, and its overexpression is usually associated with cell survival and tumor progression in various cancers. In this study, we aim to develop novel exosomes with dual HER2-targeting ability as a nanoparticle delivery vehicle to enhance antitumor efficacy in vivo . Results: Here, we report the generation of two kinds of exosomes carrying miRNAs designed to block HER2 synthesis and consequently kill tumor cells. 293-miR-HER2 exosomes package and deliver designed miRNAs to cells to block HER2 synthesis. These exosomes kill cancer cells dependent on HER2 for survival but do not affect cells that lack HER2 or that are engineered to express HER2 but are not dependent on it for survival. In contrast, 293-miR-XS-HER2 exosomes carry an additional peptide, which enables them to adhere to HER2 on the surface of cancer cells. Consequently, these exosomes preferentially enter and kill cells with surface expression of HER2. 293-miR-XS-HER2 exosomes are significantly more effective than the 293-miR-HER2 exosomes in shrinking HER2-positive tumors implanted in mice. Conclusions: Collectively, as novel antitumor drug delivery vehicles, HER2 dual-targeting exosomes exhibit increased target-specific delivery efficiency and can be further utilized to develop new nanoparticle-based targeted therapies.

scholarly journals pH-Labile Magnetic Nanocarriers for Intracellular Drug Delivery to Tumor Cells

ACS Omega ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 11728-11736 ◽  
Author(s):  
Santosh L. Gawali ◽  
Kanhu C. Barick ◽  
Neena G. Shetake ◽  
Vasumathy Rajan ◽  
Badri. N. Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Intracellular Drug Delivery ◽  
Magnetic Nanocarriers

Cyclic RGDyK conjugation facilitates intracellular drug delivery of polymeric micelles to integrin-overexpressing tumor cells and neovasculature

2010 ◽  
Vol 19 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Jie Yin ◽  
Zaiquan Li ◽  
Tingyuan Yang ◽  
Jiancheng Wang ◽  
Xuan Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Intracellular Drug Delivery

Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery

2015 ◽  
Vol 26 (11) ◽  
pp. 115101 ◽  
Author(s):  
Yanwu Cao ◽  
Min Gao ◽  
Chao Chen ◽  
Aiping Fan ◽  
Ju Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Triggered Release ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Polymeric Conjugate

Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells

2009 ◽  
Vol 131 (7) ◽  
Author(s):  
Ka Yaw Teo ◽  
Bumsoo Han
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Plasma Membranes ◽  
Cancer Cell Line ◽  
Multidrug Resistant ◽  
Drug Uptake ◽  
Freezing And Thawing ◽  
Intracellular Space ◽  
Intracellular Drug Delivery ◽  
Model Drug

The efficacy of chemotherapy is significantly impaired by the multidrug resistance (MDR) of cancer cells. The mechanism of MDR is associated with the overexpression of certain adenosine triphosphate-binding cassette protein transporters in plasma membranes, which actively pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer cell line (NCI/ADR-RES) was exposed to several F/T conditions, its cellular drug uptake was quantified by a fluorescent calcein assay using calcein as a model drug. After F/T to −20°C, the intracellular uptake of calcein increased by 70.1% (n=5, P=0.0004). It further increased to 118% as NCI/ADR-RES cells were frozen/thawed to −40°C (n=3, P=0.009). These results support the hypothesis, and possible mechanisms of F/T-enhanced intracellular drug delivery were proposed and discussed.

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