scholarly journals Thermal and pH sensitive multifunctional polymer nanoparticles for cancer imaging and therapy

RSC Advances ◽  
2014 ◽  
Vol 4 (34) ◽  
pp. 17959-17968 ◽  
Author(s):  
Tingjun Lei ◽  
Romila Manchanda ◽  
Alicia Fernandez-Fernandez ◽  
Yen-Chih Huang ◽  
Douglas Wright ◽  
...  
Keyword(s):  
Cancer Imaging ◽  
Ph Sensitive ◽  
Release Profile ◽  
Polymer Nanoparticles ◽  
Delivery Vehicle ◽  
Chemotherapy Agent ◽  
Ph Sensitive Polymer

The purpose of this study was the synthesis of a thermal and pH sensitive polymer which would provide a tunable and predictable pharmacokinetic release profile using thermal or pH stimuli. This novel and adjustable delivery vehicle was loaded with the chemotherapy agent DOX and the imaging and hyperthermia (HT) agent IR820.

pH-Sensitive Polymer Nanospheres for Use as a Potential Drug Delivery Vehicle

2007 ◽  
Vol 8 (11) ◽  
pp. 3401-3407 ◽  
Author(s):  
Jua Jung ◽  
In-Hyun Lee ◽  
Eunhye Lee ◽  
Jinho Park ◽  
Sangyong Jon
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Potential Drug ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Polymer Nanospheres ◽  
Ph Sensitive Polymer

pH Sensitive Polymer Nanoparticles: Effect of Hydrophobicity on Self-Assembly

Langmuir ◽  
2010 ◽  
Vol 26 (18) ◽  
pp. 14450-14457 ◽  
Author(s):  
Sergey K. Filippov ◽  
Larisa Starovoytova ◽  
Čestmír Koňák ◽  
Martin Hrubý ◽  
Hana Macková ◽  
...  
Keyword(s):  
Self Assembly ◽  
Ph Sensitive ◽  
Polymer Nanoparticles ◽  
Ph Sensitive Polymer

The synthesis and application of dual temperature/pH-sensitive polymer nanoparticles

2017 ◽  
Vol 181 (1) ◽  
pp. 151-155 ◽  
Author(s):  
Na Song ◽  
Gui-Huan Chen ◽  
Hai-Lin Cong ◽  
Bing Yu ◽  
Yu-Min Feng
Keyword(s):  
Ph Sensitive ◽  
Polymer Nanoparticles ◽  
Ph Sensitive Polymer

scholarly journals Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter ◽  
2017 ◽  
Vol 13 (41) ◽  
pp. 7571-7577 ◽  
Author(s):  
Monika Kluzek ◽  
Arwen I. I. Tyler ◽  
Shiqi Wang ◽  
Rongjun Chen ◽  
Carlos M. Marques ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Submicron Size ◽  
Cubic Phases ◽  
Bicontinuous Cubic ◽  
Ph Sensitive Polymer

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers.

In VivoEvaluation of pH-Sensitive Polymer-Based Immunoliposomes Targeting the CD33 Antigen

2010 ◽  
Vol 7 (4) ◽  
pp. 1098-1107 ◽  
Author(s):  
Pierre Simard ◽  
Jean-Christophe Leroux
Keyword(s):  
Ph Sensitive ◽  
Ph Sensitive Polymer

scholarly journals INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION

2021 ◽  
pp. 331-335
Author(s):  
EMMANUEL O. OLORUNSOLA ◽  
IMO E. UDOH ◽  
STEPHEN O. MAJEKODUNMI ◽  
INIOBONG J. ODIONG ◽  
UWAKMFON O. EBONG
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Ph Sensitive ◽  
Tablet Formulation ◽  
Direct Compression ◽  
Dissolution Medium ◽  
Ultraviolet Spectrophotometry ◽  
Substantial Inhibition ◽  
Ph Sensitive Polymer

Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug. Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded. Results: Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively. Conclusion: Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.

scholarly journals Fabrication of potentiometric enzyme sensors based on a pH-sensitive polymer-coated Ag electrode.

1987 ◽  
Vol 35 (11) ◽  
pp. 4568-4573 ◽  
Author(s):  
JUN-ICHI ANZAI ◽  
MASAHIKO SHIMADA ◽  
HONGDA Fu ◽  
TETSUO OSA
Keyword(s):  
Ph Sensitive ◽  
Ag Electrode ◽  
Enzyme Sensors ◽  
Ph Sensitive Polymer
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