scholarly journals Influence of a pH-sensitive polymer on the structure of monoolein cubosomes

Soft Matter ◽  
2017 ◽  
Vol 13 (41) ◽  
pp. 7571-7577 ◽  
Author(s):  
Monika Kluzek ◽  
Arwen I. I. Tyler ◽  
Shiqi Wang ◽  
Rongjun Chen ◽  
Carlos M. Marques ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Submicron Size ◽  
Cubic Phases ◽  
Bicontinuous Cubic ◽  
Ph Sensitive Polymer

Cubosomes consist in submicron size particles of lipid bicontinuous cubic phases stabilized by surfactant polymers.

scholarly journals Calculations of and Evidence for Chain Packing Stress in Inverse Lyotropic Bicontinuous Cubic Phases

Langmuir ◽  
2007 ◽  
Vol 23 (13) ◽  
pp. 7276-7285 ◽  
Author(s):  
Gemma C. Shearman ◽  
Bee J. Khoo ◽  
Mary-Lynn Motherwell ◽  
Kenneth A. Brakke ◽  
Oscar Ces ◽  
...  
Keyword(s):  
Chain Packing ◽  
Cubic Phases ◽  
Bicontinuous Cubic

In VivoEvaluation of pH-Sensitive Polymer-Based Immunoliposomes Targeting the CD33 Antigen

2010 ◽  
Vol 7 (4) ◽  
pp. 1098-1107 ◽  
Author(s):  
Pierre Simard ◽  
Jean-Christophe Leroux
Keyword(s):  
Ph Sensitive ◽  
Ph Sensitive Polymer

scholarly journals INHIBITION OF GASTRIC DEGRADATION OF OMEPRAZOLE USING A pH-SENSITIVE POLYMER AS A BINDER IN TABLET FORMULATION

2021 ◽  
pp. 331-335
Author(s):  
EMMANUEL O. OLORUNSOLA ◽  
IMO E. UDOH ◽  
STEPHEN O. MAJEKODUNMI ◽  
INIOBONG J. ODIONG ◽  
UWAKMFON O. EBONG
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Ph Sensitive ◽  
Tablet Formulation ◽  
Direct Compression ◽  
Dissolution Medium ◽  
Ultraviolet Spectrophotometry ◽  
Substantial Inhibition ◽  
Ph Sensitive Polymer

Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug. Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the batches labelled F1 to F6 respectively. A batch containing 15% hydroxypropyl methylcellulose (F7) was also formulated. The tablets were characterized; and dissolution in a pH 1.2 dissolution medium over 120 min period was studied. Aliquots taken every 20 min were analyzed by ultraviolet spectrophotometry to determine the amount of drug released and not degraded. Results: Amounts of drug released and not degraded at time 120 min were 53.1%, 57.3%, 57.8%, 58.8%, 62.1%, 83.4% and 90.0% for F1 to F7 respectively. Conclusion: Afzelia gum at a concentration of 30% is suitable for use as a binder in tablet formulation of omeprazole to ensure substantial inhibition of gastric degradation of the drug.

Kinetics of Lyotropic Phase Transitions Involving the Inverse Bicontinuous Cubic Phases

Langmuir ◽  
2000 ◽  
Vol 16 (8) ◽  
pp. 3578-3582 ◽  
Author(s):  
A. Squires ◽  
R. H. Templer ◽  
O. Ces ◽  
A. Gabke ◽  
J. Woenckhaus ◽  
...  
Keyword(s):  
Phase Transitions ◽  
Cubic Phases ◽  
Bicontinuous Cubic ◽  
Kinetics Of
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